Qhov sib txawv tseem ceeb ntawm allosteric thiab covalent modulation yog tias allosteric modulation yuav tsum muaj phosphatase enzyme, whereas covalent modulation yuav tsum muaj kinase enzyme.
Kev hloov pauv ntawm ib qho enzyme yog kev hloov kho ntawm qhov chaw uas lub receptor lossis lub ligand yuav khi nrog ib qho enzyme. Muaj ntau hom modulations, thiab allosteric thiab covalent modulation yog ob ntawm lawv.
Allosteric Modulation yog dab tsi?
Allosteric modulation yog ib lo lus nyob rau hauv pharmacology thiab biochemistry uas yog hais txog ib pawg ntawm cov khoom uas khi rau ib tug receptor los hloov cov receptor cov lus teb rau stimulus. Qee cov modulators no yog cov tshuaj, xws li. tshuaj benzodiazepines. Allosteric site yog qhov chaw uas ib qho allosteric modulator khi rau. Nws tsis yog tib yam uas tus endogenous agonist ntawm receptor yuav khi (qhov chaw tshwj xeeb no yog lub npe hu ua orthosteric site). Peb tuaj yeem hu rau ob qho tib si modulators thiab agonists ua receptor ligands.
Ntxiv mus, muaj peb yam loj ntawm allosteric modulators: zoo, tsis zoo, thiab nruab nrab modulations. Hom zoo tuaj yeem ua rau cov lus teb ntawm receptor los ntawm kev nce qhov tshwm sim ntawm agonist khi nrog receptor, los ntawm kev ua kom muaj peev xwm ua kom lub receptor (qhov no yog hu ua kev ua tau zoo), lossis los ntawm ob txoj kev no. Ntawm qhov tod tes, hom tsis zoo tuaj yeem txo qis agonist affinity thiab ua tau zoo. Thaum kawg, hom nruab nrab tsis cuam tshuam rau kev ua haujlwm agonist, tab sis nws tuaj yeem txwv lwm cov modulators los ntawm kev khi rau ib qho chaw allosteric. Ntxiv mus, qee qhov allosteric modulators ua haujlwm li allosteric agonists.
Feem ntau, allosteric modulators muaj peev xwm hloov qhov kev sib raug zoo thiab kev ua tau zoo ntawm lwm yam tshuaj uas ua rau lub receptor. Lub modulator kuj tuaj yeem ua rau kom muaj kev sib raug zoo thiab kev ua haujlwm qis dua lossis rov ua dua. Affinity yog lub peev xwm ntawm ib yam khoom los khi rau lub receptor. Kev ua tau zoo, ntawm qhov tod tes, yog lub peev xwm ntawm cov khoom siv los qhib cov receptor uas tau muab los ua ib feem pua ntawm cov peev txheej ntawm cov khoom siv los ua kom cov receptor sib piv rau cov endogenous agonist ntawm receptor.
Covalent Modulation yog dab tsi?
Covalent kev hloov pauv yog ib lo lus tseem ceeb siv hauv biochemistry, thiab nws yog hais txog ib pawg ntawm cov khoom uas khi covalently rau cov receptor, hloov nws cov lus teb. Enzymes tuaj yeem tswj hwm los ntawm kev hloov pauv ntawm cov molecule lossis atom los ntawm tus neeg pub dawb mus rau cov amino acid sab saw uas tuaj yeem ua tus receptor ntawm cov khoom hloov pauv. Lwm txoj hauv kev ua qhov no yog hloov cov amino acid ib ntus nws tus kheej ntawm proteolytic cleavage.
Covalent kev hloov pauv cuam tshuam nrog kev hloov pauv ntawm cov duab thiab kev ua haujlwm ntawm ib qho enzyme los ntawm covalent bonding ntawm pawg tshuaj rau nws. Ntxiv mus, qhov kev hloov kho no tseem hu ua kev hloov kho tom qab kev txhais lus. Feem ntau, qhov kev hloov pauv no tshwm sim hauv endoplasmic reticulum thiab Golgi apparatus. Cov chaw uas feem ntau tuaj yeem raug hloov kho tom qab kev txhais lus yog cov chaw uas muaj pab pawg ua haujlwm ua haujlwm ua ib qho nucleophile hauv cov tshuaj tiv thaiv. Cov chaw no suav nrog pawg hydroxyl ntawm serine, threonine, thiab tyrosine, nrog rau cov ntawv amine ntawm lysine, arginine, thiab histidine.
Qhov txawv ntawm Allosteric thiab Covalent Modulation yog dab tsi?
Qhov sib txawv tseem ceeb ntawm allosteric thiab covalent modulation yog tias allosteric modulation yuav tsum muaj phosphatase enzyme, whereas covalent modulation yuav tsum muaj kinase enzyme.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm allosteric thiab covalent modulation nyob rau hauv daim ntawv tabular rau kev sib piv ntawm ib sab.
Summary – Allosteric vs Covalent Modulation
Allosteric modulation yog hais txog ib pawg ntawm cov khoom uas khi rau cov receptor los hloov cov receptor cov lus teb rau qhov kev txhawb nqa, thaum covalent modulation yog hais txog ib pawg ntawm cov khoom uas khi cov lus cog tseg rau cov receptor thiab hloov nws cov lus teb. Qhov sib txawv tseem ceeb ntawm allosteric thiab covalent modulation yog tias allosteric modulation yuav tsum muaj phosphatase enzyme, whereas covalent modulation yuav tsum muaj kinase enzyme.
