Qhov sib txawv tseem ceeb ntawm neurofibroma thiab neurofibromatosis yog tias neurofibroma yog ib qho mob uas benign, qeeb-loj hlob paj hlwb-sheath hlav loj hlob nyob rau hauv lub paj hlwb peripheral, thaum neurofibromatosis yog ib pawg ntawm peb yam mob uas benign hlav loj hlob nyob rau hauv kev txhawb nqa. hlwb thiab neurons ntawm lub paj hlwb.
Cov kab mob paj hlwb feem ntau tsim nyob rau hauv lub hlwb thiab qaum qaum. Lawv tuaj yeem yog benign (non-cancerous) lossis malignant (cancerous). Cov qog uas pib loj hlob hauv lub paj hlwb yog thawj cov qog, thaum cov qog uas pib nyob rau lwm qhov hauv lub cev thiab kis mus rau lub paj hlwb yog cov qog ntshav thib ob (metastatic). Cov qog no tuaj yeem cuam tshuam ob qho tib si hauv nruab nrab thiab peripheral paj hlwb. Neurofibroma thiab neurofibromatosis yog ob hom mob uas cov qog nqaij hlav loj hlob hauv lub paj hlwb.
Neurofibroma yog dab tsi?
Neurofibroma yog ib yam mob uas benign, qeeb-loj hlob paj hlwb hlav hauv lub paj hlwb peripheral. Hauv 90% ntawm cov neeg mob, nws yog ib leeg-ib leeg lossis ib leeg mob qog nqaij hlav. Nyob rau hauv tas li ntawd, nws muaj nyob rau hauv cov neeg uas muaj neurofibromatosis hom I. Ib tug neurofibroma muaj peev xwm tsim nyob rau hauv ib tug loj los yog me me los yog paj hlwb nyob txhua qhov chaw ntawm lub cev. Cov tsos mob feem ntau yog mob me lossis tsis tuaj. Txawm li cas los xij, yog tias cov qog nqaij hlav tawm tsam cov hlab ntsha lossis loj hlob hauv lawv, tib neeg yuav raug mob lossis loog loog hauv thaj chaw cuam tshuam. Qhov ua rau ntawm tus kab mob neurofibroma sporadic tsis paub. Tab sis lwm yam neurofibromas tshwm sim los ntawm cov hlwb uas tsis yog-myelinated Schwann uas tsuas yog qhia qhov tsis muaj zog ntawm NF1 noob. Qhov no ua rau kom tsis muaj kev qhia txog kev ua haujlwm neurofibromin.
Daim duab 01: Neurofibroma
Tus mob no tau muab faib ua ob pawg: dermal thiab plexiform. Dermal neurofibromas yog txuam nrog ib leeg peripheral paj hlwb, thaum plexiform neurofibromas cuam tshuam nrog ntau lub paj hlwb. Dermal neurofibroma ntxiv faib rau hauv; daim tawv nqaij, subcutaneous, thiab tob nodular. Kev kuaj mob tuaj yeem ua tau los ntawm kev kuaj ntshav, biopsy, MRI lossis electromyography (EMG / NCV). Cov kev kho mob suav nrog kev phais, hluav taws xob, tshuaj khomob, ACE inhibitors, MEK inhibitors, thiab tshuaj xws li sirolimus, erlotinib, peginterferon alfa-2b, sorafenib, thiab lwm yam. Gene therapy for neurofibromin I gene tej zaum yuav yog kev kho mob yav tom ntej.
Neurofibromatosis yog dab tsi?
Neurofibromatosis yog ib pawg ntawm peb yam mob (neurofibromatosis I, neurofibromatosis II, thiab schwannomatosis) uas cov qog nqaij hlav loj hlob hauv kev txhawb nqa hlwb thiab cov paj hlwb ntawm lub paj hlwb. Hauv neurofibromatosis I, cov tsos mob muaj xws li lub teeb xim av ntawm daim tawv nqaij, freckles nyob rau hauv caj npab thiab puab tais, pob hauv paj hlwb thiab scoliosis. Hauv neurofibromatosis II, cov tsos mob muaj xws li tsis hnov lus, cataracts thaum tseem hluas, teeb meem sib npaug, nqaij tawv nqaij tawv nqaij, thiab nqaij ntshiv. Tsis tas li ntawd, nyob rau hauv schwannomatosis, tej zaum yuav muaj mob nyob rau hauv ib qho chaw los yog nyob rau hauv ntau qhov chaw ntawm lub cev. Neurofibromatosis feem ntau tshwm sim los ntawm kev txhawb cov hlwb ntawm lub paj hlwb es tsis yog cov neurons lawv tus kheej.
Daim duab 02: Neurofibromatosis
Neurofibromatosis yog tshwm sim los ntawm kev hloov pauv ntawm caj ces hauv qee cov genes uas tuaj yeem tau txais los yog tshwm sim tshwm sim. Neurofibromatosis I yog tshwm sim los ntawm kev hloov pauv ntawm NF1 noob ntawm chromosome 17. Neurofibromatosis II yog tshwm sim los ntawm kev hloov pauv ntawm NF2 noob ntawm chromosome 22. Schwannomatosis yog vim muaj ntau yam kev hloov pauv ntawm chromosome 22. Kev kuaj mob yog los ntawm kev kuaj mob, kuaj ntshav, thiab kuaj caj ces. Txoj kev npaj kho mob suav nrog kev phais, hluav taws xob, tshuaj khomob, kev cog lus cog qoob loo, lossis kev cog qoob loo ntawm lub paj hlwb rau cov neeg uas hnov lus tsis zoo vim qhov mob no.
Dab tsi zoo sib xws ntawm Neurofibroma thiab Neurofibromatosis?
- Neurofibroma thiab neurofibromatosis yog ob hom mob uas cov qog nqaij hlav loj hlob hauv lub paj hlwb.
- Ob qho xwm txheej tau qeeb qeeb.
- Cov xwm txheej no feem ntau tsis yog mob qog noj ntshav.
- Lawv tuaj yeem yog vim kev hloov pauv caj ces ntawm NF1 noob.
- Lawv kho tau nrog kev phais tshem tawm, hluav taws xob thiab tshuaj khomob.
Qhov txawv ntawm Neurofibroma thiab Neurofibromatosis yog dab tsi?
Neurofibroma yog ib qho mob uas benign qeeb-loj hlob paj hlwb hlav loj hlob nyob rau hauv lub paj hlwb peripheral, thaum neurofibromatosis yog ib pawg ntawm peb yam mob, neurofibromatosis I, neurofibromatosis II, thiab schwannomatosis, nyob rau hauv uas benign hlav loj hlob nyob rau hauv kev txhawb nqa. cell thiab neurons ntawm lub paj hlwb. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm neurofibroma thiab neurofibromatosis. Tsis tas li ntawd, neurofibroma cuam tshuam tsuas yog lub paj hlwb peripheral, thaum neurofibromatosis cuam tshuam rau ob qho tib si peripheral thiab hauv nruab nrab lub paj hlwb.
Cov lus hauv qab no qhia txog qhov sib txawv ntawm neurofibroma thiab neurofibromatosis.
Summary – Neurofibroma vs Neurofibromatosis
Cov kab mob paj hlwb feem ntau cuam tshuam rau ob qho tib si peripheral thiab hauv nruab nrab paj hlwb. Neurofibroma thiab neurofibromatosis yog ob hom mob uas cov qog nqaij hlav loj hlob hauv lub paj hlwb. Neurofibroma yog ib qho mob uas benign qeeb-loj hlob paj hlwb hlav loj hlob nyob rau hauv lub paj hlwb peripheral, thaum neurofibromatosis yog ib pawg ntawm peb yam mob (neurofibromatosis I, neurofibromatosis II, thiab schwannomatosis) nyob rau hauv uas benign hlav loj hlob nyob rau hauv kev txhawb nqa hlwb thiab neurons ntawm lub hlwb. paj hlwb. Yog li, qhov no qhia txog qhov sib txawv ntawm neurofibroma thiab neurofibromatosis.
