Qhov sib txawv tseem ceeb ntawm H1 thiab H2 blockers yog H1 blockers xa mus rau cov tebchaw uas cuam tshuam cov haujlwm ntawm H1 histamine receptors uas tshwm sim thoob plaws hauv vascular endothelial hlwb nyob rau hauv lub plawv thiab lub hauv nruab nrab lub paj hlwb, thaum H2 blockers xa mus rau cov tebchaw uas inhibit qhov kev ua ntawm H 2histamine receptors uas feem ntau tshwm sim hauv parietal hlwb ntawm lub plab mucosa.
Antihistamines yog cov tshuaj siv los ntawm kws kho mob los kho hay fever thiab ua xua. Feem ntau, tib neeg noj cov tshuaj antihistamines yam tsis muaj tshuaj vim tias lawv muaj kev phiv tsawg. Lawv txo cov tsos mob xws li qhov ntswg congestion, txham, los yog khaus los ntawm paj ntoos, plua plav mites, lossis tsiaj ua xua. Tab sis lawv feem ntau yog rau kev kho mob luv luv. Muaj ntau ntau hom tshuaj tiv thaiv. H1 thiab H2 blockers yog ob hom tshuaj tiv thaiv kab mob tseem ceeb siv los kho kev tsis haum tshuaj.
H1 Blockers yog dab tsi?
H1 blockers xa mus rau cov tebchaw uas inhibit qhov kev ua ntawm H1 histamine receptors. Lawv tshwm sim thoob plaws lub vascular endothelial hlwb nyob rau hauv lub plawv thiab lub paj hlwb. Lawv kuj hu ua H1 antagonists lossis H1 antihistamines. Lawv pab txo cov tsos mob ntawm kev tsis haum tshuaj. H1 histamine receptors nthuav tawm kev ua haujlwm. Yog li, H1 blockers tuaj yeem yog nruab nrab receptor antagonists lossis inverse agonists. Neutral receptor antagonists ua haujlwm los ntawm kev khi rau H1 receptor thiab thaiv kev ua kom cov receptor los ntawm histamine. Ntawm qhov tod tes, inverse agonists ua hauj lwm los ntawm kev khi rau H1 receptor thiab thaiv qhov khi ntawm histamine, thiab txo cov kev ua haujlwm ntawm H1 receptor.
Daim duab 01: H1 Blockers – Cetirizine
Hauv kev teeb tsa kho mob, H1 blockers tau siv los kho cov kev tsis haum tshuaj thiab cov kab mob ntawm tes. Sedation yog ib qho kev mob tshwm sim feem ntau ntawm H1 blockers. Yog li ntawd, lawv yog (diphenhydramine thiab doxylamine) ib txwm siv los kho insomnia. Ntxiv mus, H1 blockers kuj tuaj yeem siv los txo cov kev mob tshwm sim. Qee qhov piv txwv rau H1 blockers yog acrivastine, buclizine, cetirizine, desloratadine, hydroxyzine, levocetirizine, maprotiline, promethazine, phenyltoloxamine, orphenadrine, tripelennamine, thiab lwm yam.
H2 Blockers yog dab tsi?
H2 blockers xa mus rau cov tebchaw uas inhibit qhov kev ua ntawm H2 histamine receptors. Lawv feem ntau tshwm sim nyob rau hauv parietal hlwb ntawm lub plab mucosa. Lawv kuj hu ua H2 antihistamine lossis H1 antagonists (H2RAs). Lawv ib txwm muaj nyob ua tus agonists inverse thiab nruab nrab antagonists. Cov H2 antihistamines ua raws li H2 histamine receptors, feem ntau nyob rau hauv parietal hlwb ntawm lub plab mucosa. Parietal hlwb ntawm gastric mucosa yog ib feem ntawm endogenous signaling txoj kev rau gastric acid secretion. Feem ntau, histamine ua raws li H2 receptors rau induce acid secretion. Yog li, H2 blockers inhibit H2 signaling thiab txo qis cov kua qaub gastric.
Daim duab 02: H2 Blockers – Cimetidine
H2 blockers yog thawj kab kev kho mob rau cov kab mob hauv plab, nrog rau cov kab mob peptic thiab kab mob gastroesophageal reflux. Tsis tas li ntawd, lawv kuj tau siv rau kev kho mob ntawm dyspepsia. Cov piv txwv ntawm H2 blockers yog cimetidine, ranitidine, famotidine, nizatidine, roxatidine, lafutidine, lavoltidine, thiab niperotidine, thiab lwm yam.
Dab tsi yog qhov zoo sib xws ntawm H1 thiab H2 Blockers?
- ob leeg yog hom tshuaj tiv thaiv kab mob.
- Lawv thaiv cov histamines receptors.
- Lawv siv los kho tib neeg cov kab mob.
- Ob leeg muaj nyob hauv nruab nrab receptor antagonists lossis inverse agonists.
Qhov txawv ntawm H1 thiab H2 Blockers yog dab tsi?
H1 blockers xa mus rau cov tebchaw uas inhibit qhov kev ua ntawm H1 histamine receptors uas tshwm sim thoob plaws hauv cov hlab ntsha endothelial hauv cov hlab ntsha. plawv thiab central paj hlwb. Ntawm qhov tod tes, H2 blockers xa mus rau cov tebchaw uas cuam tshuam cov haujlwm ntawm H2 histamine receptors uas feem ntau tshwm sim hauv cov hlwb parietal ntawm cov hlab ntsha. plab mucosa. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm H1 thiab H2 blockers. Tsis tas li ntawd, H1 blockers tau pom nyob rau xyoo 1933, thaum H2 blockers tau pom ntau tom qab xyoo 1964.
Cov infographic hauv qab no teev qhov sib txawv ntawm H1 thiab H2 blockers hauv daim ntawv teev npe.
Summary – H1 vs H2 Blockers
Tam sim no, neeg feem coob siv tshuaj tiv thaiv kab mob los kho kev ua xua. Thawj tiam ntawm antihistamines muaj nyob rau hauv 1930s. H1 thiab H2 blockers yog ob qho tshuaj tiv thaiv kab mob. H1 blockers cuam tshuam rau lub qhov ntswg, thaum H2 blockers cuam tshuam rau lub plab. Tsis tas li ntawd, H1 blockers xa mus rau cov tebchaw uas cuam tshuam cov haujlwm ntawm H1 histamine receptors, thaum H 2blockers xa mus rau cov tebchaw uas inhibit qhov kev ua ntawm H2 histamine receptors. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm H1 thiab H2 blockers.
