Qhov sib txawv tseem ceeb ntawm alpha thiab beta blockers yog tias alpha blockers yog cov tshuaj uas txo cov ntshav siab los ntawm kev tiv thaiv cov tshuaj hormone norepinephrine los ntawm nruj cov nqaij leeg hauv cov phab ntsa ntawm cov hlab ntsha thiab cov leeg, thaum beta blockers yog cov tshuaj uas txo cov ntshav. siab los ntawm thaiv cov teebmeem ntawm cov tshuaj hormone epinephrine thiab txo lub plawv dhia.
Hypertension yog ib yam kab mob hnyav hauv ntiaj teb tam sim no. Txhawm rau tiv thaiv cov kab mob zoo li no, tib neeg lub cev yuav tsum muaj cov tshuaj tiv thaiv kab mob uas tuaj yeem pab cov hlab ntsha thiab cov hlab ntsha hauv cov ntshav khiav zoo. Alpha thiab beta blockers yog ob qho tib si ntshav siab-txo cov tshuaj uas siv rau hauv kev kho mob los ntawm cov kws kho mob.
Alpha Blockers yog dab tsi?
Alpha blockers yog cov tshuaj uas txo cov ntshav siab los ntawm kev tiv thaiv cov tshuaj hormone norepinephrine los ntawm kev ua kom cov leeg du hauv cov phab ntsa ntawm cov hlab ntsha thiab cov hlab ntsha. Lawv yog ib pawg ntawm cov tshuaj uas ua rau α-adrenergic receptors. Norepinephrine yog agonist rau cov receptors. Cov receptors no muaj kev ua haujlwm zoo, xws li vasoconstriction. Yog li ntawd, alpha blockers tiv thaiv cov haujlwm no thaum khi rau cov receptor. Raws li qhov tshwm sim ntawm alpha blockers khi rau lawv cov receptors, cov hlab ntsha tseem qhib thiab so. Qhov no txhim kho cov ntshav khiav thiab txo cov ntshav siab.
Daim duab 01: Alpha Blockers
Alpha blockers muaj ob hom: ua haujlwm luv luv thiab ua haujlwm ntev. Cov tshuaj ua haujlwm luv luv ua haujlwm sai heev, tab sis lawv cov teebmeem yuav kav ntev li ob peb teev. Txawm li cas los xij, cov tshuaj ua haujlwm ntev siv sijhawm ntev dua los ua haujlwm, tab sis lawv cov teebmeem ntev dua. Yog li, hom alpha blockers nyob ntawm cov neeg mob cov mob. Piv txwv ntawm alpha blockers siv los kho cov ntshav siab xws li doxazosin, prazosin, terazosin, thiab lwm yam. Alpha blockers tsis yog thawj txoj kev kho mob ntshav siab. Cov kev mob tshwm sim muaj xws li kiv taub hau, mob taub hau, mob plawv dhia, tsis muaj zog, thiab lwm yam. Feem ntau, lwm yam tshuaj xws li diuretics yog siv thaum ntshav siab tswj tsis tau. Ntxiv mus, alpha blockers tuaj yeem kho lwm yam kab mob xws li Raynaud's kab mob, benign prostatic hyperplasia thiab erectile kawg li.
Dab tsi yog Beta Blockers?
Beta blockers yog cov tshuaj uas txo cov ntshav siab los ntawm kev thaiv cov tshuaj hormone epinephrine thiab txo lub plawv dhia. Lawv yog cov antagonists ntawm receptors rau catecholamines xws li epinephrine. Cov receptors no yog adrenergic beta receptors ntawm lub paj hlwb sympathetic uas kho cov lus teb sib ntaus sib tua. Qee cov beta blockers thaiv kev ua kom txhua yam ntawm β-adrenergic receptors. Qee qhov yog xaiv rau ib qho ntawm peb lub npe beta receptors: β1, β2, thiab β3 receptors. β1-adrenergic receptors feem ntau yog nyob rau hauv lub plawv thiab lub raum. β2-adrenergic receptor tuaj yeem pom nyob rau hauv lub ntsws, daim siab, plab hnyuv, lub tsev menyuam, cov leeg nqaij leeg, thiab cov leeg pob txha. Ntxiv mus, β3-adrenergic receptor muaj nyob rau hauv cov rog rog.
Daim duab 02: Mechanism of Action of Beta Blockers
Beta blockers feem ntau yog siv los kho lub plawv dhia tsis zoo thiab tiv thaiv cov neeg mob los ntawm lub plawv thib ob tom qab thawj lub plawv nres. Qee qhov piv txwv ntawm beta blockers yog acebutolol, atenolol, bisoprolol, metoprolol, nadolol, nebivolol, thiab propranolol. Lawv kuj muaj cov kev mob tshwm sim xws li txhais tes txias lossis ko taw, qaug zog, hnyav nce, kev nyuaj siab, ua tsis taus pa thiab teeb meem pw tsaug zog, thiab lwm yam.
Dab tsi zoo sib xws ntawm Alpha thiab Beta Blockers?
- Alpha thiab beta blockers ob leeg txo cov ntshav siab.
- ob leeg yog tshuaj.
- Lawv yog ob leeg antagonists ntawm receptors rau catecholamine.
- Ob leeg blockers pab hauv cov hlab ntsha.
Qhov txawv ntawm Alpha thiab Beta Blockers yog dab tsi?
Alpha blockers txo cov ntshav siab los ntawm kev tiv thaiv cov tshuaj hormone norepinephrine los ntawm nruj cov leeg nqaij hauv cov phab ntsa ntawm cov hlab ntsha thiab cov leeg. Hauv qhov sib piv, beta blockers txo cov ntshav siab los ntawm kev thaiv cov teebmeem ntawm cov tshuaj hormone epinephrine thiab txo lub plawv dhia. Qhov no yog qhov sib txawv tseem ceeb ntawm alpha thiab beta blockers. Tsis tas li ntawd, alpha blockers cuam tshuam rau cov tshuaj norepinephrine, thaum beta blockers cuam tshuam rau cov tshuaj hormone epinephrine.
Cov infographic hauv qab no nthuav tawm qhov sib txawv ntawm alpha thiab beta blockers hauv daim ntawv tabular.
Summary – Alpha vs Beta Blockers
Adrenergic antagonists xws li alpha thiab beta blockers inhibit qhov kev ua haujlwm ntawm adrenergic receptors zoo li α-adrenergic receptors thiab β-adrenergic receptors. Yog li ntawd, alpha thiab beta blockers yog ob qho tib si cov tshuaj uas txo cov ntshav siab. Alpha blockers yog cov tshuaj uas txo cov ntshav siab los ntawm kev tiv thaiv cov tshuaj hormone norepinephrine los ntawm nruj cov leeg nqaij hauv cov phab ntsa ntawm cov hlab ntsha thiab cov hlab ntsha. Hauv qhov sib piv, beta blockers yog cov tshuaj uas txo cov ntshav siab los ntawm kev thaiv cov teebmeem ntawm cov tshuaj hormone epinephrine thiab txo lub plawv dhia. Nov yog cov ntsiab lus ntawm qhov sib txawv ntawm alpha thiab beta blockers.
