Qhov sib txawv tseem ceeb ntawm allelic thiab locus heterogeneity yog tias allelic heterogeneity yog lub peev xwm ntawm kev hloov pauv sib txawv hauv tib lub noob los ua tib yam kab mob thaum locus heterogeneity yog lub peev xwm ntawm kev hloov pauv hauv ntau cov noob sib txawv los ua tib yam. kab mob.
Txiv neej heterogeneity yog lub peev xwm ntawm cov txheej txheem caj ces sib txawv los tsim cov phenotypes zoo ib yam. Kev hloov pauv hauv qhov chaw sib txawv ntawm tib lub noob lossis kev hloov pauv hauv cov noob sib txawv tuaj yeem tsim cov noob caj noob ces heterogeneity. Muaj ob hom genetic heterogeneity li allelic thiab locus heterogeneity. Allelic heterogeneity piav qhia txog lub peev xwm ntawm kev hloov pauv sib txawv hauv tib lub noob (sib txawv alleles ntawm ib qho chaw) los tsim cov kab mob sib txawv, tshwj xeeb tshaj yog kab mob. Locus heterogeneity piav qhia txog lub peev xwm ntawm kev hloov pauv ntawm cov gene loci sib txawv los ua rau tib tus kab mob phenotype.
Allelic Heterogeneity yog dab tsi?
Allelic heterogeneity yog lub peev xwm ntawm kev hloov pauv sib txawv hauv tib lub noob los ua rau tib tus kab mob. Hauv lwm lo lus, allelic heterogeneity yog kev tsim cov phenotype zoo sib xws los ntawm cov alleles sib txawv hauv tib lub noob. Qhov no qhia tau tias muaj ntau yam kev hloov pauv hauv tib lub noob. Ntau qhov kev hloov pauv yog ib qho kev hloov pauv nucleotide lossis hloov pauv. Allelic heterogeneity tuaj yeem tshwm sim vim muaj ntau yam, suav nrog kev xaiv ntuj, exogenous mutagens, genetic drift, lossis genetic migration.
Daim duab 01: Allelic Heterogeneity
Cystic fibrosis yog qhov piv txwv zoo tshaj plaws ntawm tus kab mob tshwm sim los ntawm allelic heterogeneity. Kev hloov pauv sib txawv (kwv yees li 1500 kev hloov pauv) hauv cov noob CFTR tuaj yeem ua rau cystic fibrosis. Lwm qhov piv txwv yog Alkaptonuria, uas yog ib qho kab mob tsis tshua muaj caj ces hauv tib neeg.
Locus Heterogeneity yog dab tsi?
Locus heterogeneity yog ib hom kab mob genetic heterogeneity uas tsim cov phenotype zoo sib xws los ntawm kev hloov pauv ntawm qhov sib txawv / cov noob. Hauv lwm lo lus, locus heterogeneity yog lub peev xwm los tsim cov phenotypes zoo ib yam lossis zoo tib yam phenotypes los ntawm kev hloov pauv ntawm ntau cov noob, tshwj xeeb tshaj yog ob lossis ntau cov noob.
Daim duab 02: Locus Heterogeneity
Cornelia de Lange syndrome yog qhov piv txwv zoo tshaj plaws ntawm tus kab mob tshwm sim los ntawm qhov chaw heterogeneity. Tus kab mob no tuaj yeem kis tau los ntawm ib qho kev hloov pauv hauv ib qho ntawm tsib lub noob sib txawv: NIPBL, SMC1A, HDAC8, RAD21, thiab SMC3. Nyob rau hauv sib piv rau allelic heterogeneity, locus heterogeneity yog "nonallelic".
Dab tsi zoo sib xws ntawm Allelic thiab Locus Heterogeneity?
- Allelic thiab locus heterogeneity yog ob hom genetic heterogeneity.
- Lawv tsim tib yam phenotypes lossis zoo tib yam phenotypes ntawm cov txheej txheem caj ces sib txawv.
- Lawv tshwm sim los ntawm kev hloov pauv hauv gene locus lossis loci.
Qhov txawv ntawm Allelic thiab Locus Heterogeneity yog dab tsi?
Nyob rau hauv allelic heterogeneity, sib txawv alleles nyob rau hauv tib lub noob yuav ua rau ib tug zoo xws li phenotype thaum nyob rau hauv locus heterogeneity, kev hloov nyob rau hauv txawv noob los yog loci yuav ua tau ib tug zoo xws li phenotype. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm allelic thiab locus heterogeneity. Cystic fibrosis yog ib qho piv txwv ntawm tus kab mob tshwm sim los ntawm allelic heterogeneity thaum Cornelia de Lange syndrome yog ib qho piv txwv ntawm tus kab mob tshwm sim los ntawm locus heterogeneity.
Hauv qab infographic ntawm qhov sib txawv ntawm allelic thiab locus heterogeneity qhia ntau qhov sib piv ntawm ob qho tib si.
Summary – Allelic vs Locus Heterogeneity
Allelic thiab locus heterogeneity yog ob hom genetic heterogeneity uas tsim cov phenotypes zoo sib xws los ntawm cov txheej txheem caj ces, tshwj xeeb tshaj yog kev hloov pauv. Allelic heterogeneity yog hais txog kev tsim cov phenotype tib yam los ntawm kev hloov pauv sib txawv tshwm sim hauv tib lub noob. Hauv qhov sib piv, locus heterogeneity yog hais txog kev tsim cov phenotypes zoo tib yam los ntawm kev hloov pauv tshwm sim hauv cov noob sib txawv lossis loci. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm allelic thiab locus heterogeneity. Cov alleles sib txawv ntawm ib qho chaw muaj lub luag haujlwm rau allelic heterogeneity thaum sib txawv loci lossis cov noob muaj lub luag haujlwm rau locus heterogeneity.
