Qhov sib txawv tseem ceeb ntawm homodimer thiab heterodimer yog homodimer yog cov protein ua los ntawm ob lub proteins uas zoo ib yam, thaum heterodimer yog cov protein ua los ntawm ob hom proteins.
Y Protein yog biomolecule uas muaj cov amino acid chains. Ib qho protein dimer yog ib qho quaternary protein qauv tsim los ntawm kev sib koom ua ke ntawm ob lub protein monomers los yog ob lub amino acid chains. Feem ntau, lawv khi nrog ib leeg los ntawm cov nyiaj tsis sib xws. Protein dimers yog homodimer lossis heterodimers. Ib homodimer muaj ob yam proteins uas tsis yog-covalently khi. Heterodimer muaj ob hom proteins sib txawv ua ke. Qhov kev sib cuam tshuam ntawm cov protein dimer no tseem ceeb hauv kev tswj hwm thiab catalysis.
Homodimer yog dab tsi?
Homodimer yog ib hom protein dimer uas muaj ob lub monomers zoo tib yam. Cov monomers khi nrog non-covalent bonds. Feem ntau, muaj 18 tus lej ntawm H bonds hauv homodimers. Ntxiv mus, qhov sib txheeb coefficient ntawm H-bonds thiab interface residues hauv homodimer yog 0.85. Tsis tas li ntawd, qhov siab tshaj plaws ntawm H daim ntawv cog lus rau ib qho chaw seem ntawm homodimer yog 0.44. Tsis tas li ntawd xwb, tab sis muaj ntau qhov sib txawv ntawm H bonds hauv homodimers ib yam nkaus. Txawm li cas los xij, qhov ceev ntawm H bonds ib qho residue yog qis dua hauv homodimers.
Daim duab 01: Homodimer
Thaum xav txog cov piv txwv rau homodimers, chav kawm 1 RNAs yog homodimers. Hauv homodimer no, R1 protein yog lub luag haujlwm rau kev txo cov nucleotide thaum R2 protein yog lub luag haujlwm rau lub tsev nyob hauv diiron tyrosyl array. Lwm homodimer protein yog thyroglobulin tsim los ntawm cov thyroid caj pas. Xanthine oxidase thiab etanercept kuj yog protein homodimers.
Heterodimer yog dab tsi?
Lub heterodimer yog ib hom protein dimer complexed los ntawm ob lub monomers tsis zoo ib yam. Hauv lwm lo lus, heterodimer yog cov protein uas muaj ob hom protein monomers sib txawv. Feem ntau, muaj 12 tus lej ntawm H bonds hauv heterodimers. Ntxiv mus, qhov sib txheeb coefficient ntawm H-bonds thiab interface residues hauv heterodimer yog 0.83. Tsis tas li ntawd, qhov siab tshaj plaws ntawm H daim ntawv cog lus rau ib qho chaw seem ntawm heterodimer yog 0.65. Piv rau homodimers, muaj tsawg dua intermolecular H bonds hauv heterodimers. Txawm li cas los xij, qhov ceev ntawm H daim ntawv cog lus ib qho residue yog siab dua hauv heterodimers.
Daim duab 02: Heterodimer
Enzyme thim rov qab transcriptase yog heterodimer tsim los ntawm ob hom amino acids sib txawv. Lwm qhov piv txwv ntawm heterodimer yog opioid receptors. Ntxiv mus, tubulin yog heterodimer protein.
Qhov Zoo sib xws ntawm Homodimer thiab Heterodimer yog dab tsi?
- Homodimer thiab heterodimer yog ob hom protein dimmers.
- Ob leeg muaj ob lub monomers.
- Lawv yog quaternary protein cov qauv.
- Dimers muaj ntau hauv catalysis thiab kev tswj.
Qhov txawv ntawm Homodimer thiab Heterodimer yog dab tsi?
Homodimer yog ib qho protein dimer uas muaj ob hom protein monomers zoo tib yam thaum heterodimer yog protein dimer uas muaj ob hom protein monomers. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm homodimer thiab heterodimer. Tsis tas li ntawd, muaj 18 tus lej ntawm H bonds hauv homodimers thaum muaj 12 tus lej ntawm H bonds hauv heterodimers.
Ntxiv mus, lwm qhov sib txawv ntawm homodimer thiab heterodimer yog qhov sib txuas coefficient ntawm H-bonds thiab interface residues yog 0.85 hauv homodimers thaum nws yog 0.83 hauv heterodimers.
Cov duab hauv qab no ntawm qhov sib txawv ntawm homodimer thiab heterodimer qhia ntau qhov sib piv ntawm ob lub dimers.
Summary – Homodimer vs Heterodimer
Protein dimers muaj ntau hauv catalysis thiab kev tswj hwm. Lawv tuaj yeem yog homodimers lossis heterodimers. Homodimers yog tsim los ntawm ob qho tib si protein monomers. Hauv qhov sib piv, heterodimers yog tsim los ntawm ob qho tib si protein monomers. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm homodimer thiab heterodimer.
