Qhov sib txawv tseem ceeb ntawm enzyme inhibitor thiab enzyme inducer yog tias enzyme inhibitor txo qis kev ua haujlwm ntawm cov enzyme los ntawm kev khi nrog qhov chaw nquag ntawm cov enzyme. Nyob rau hauv sib piv, enzyme inducer tsub kom lub metabolic kev ua si ntawm ib tug enzyme los ntawm kev khi rau nws los yog los ntawm kev nce cov noob qhia.
Enzymes yog biomolecules uas catalyze biochemical tshwm sim tshwm sim hauv cov hlwb. Lawv nce tus nqi ntawm cov tshuaj tiv thaiv los ntawm kev txo qis lawv lub zog ua kom muaj zog. Substrates khi nrog lub active site ntawm lub enzyme thiab tsim lub substrate-enzyme complex. Tom qab ntawd lub substrate hloov mus rau hauv cov khoom, tawm hauv lub enzyme tom qab tsis hloov. Enzyme inhibitors txo qhov kev ua haujlwm lossis catalytic muaj peev xwm ntawm ib qho enzyme, khi nrog rau qhov chaw nquag ntawm nws. Hauv qhov sib piv, enzyme inducer nce kev ua haujlwm ntawm cov enzyme los ntawm kev khi lossis los ntawm kev txhim kho cov kev qhia ntawm cov noob uas yog coding cov enzyme.
Tus Enzyme Inhibitor yog dab tsi?
Ib qho enzyme inhibitor yog ib qho molecule uas txo cov enzyme kev ua los ntawm kev khi rau nws. Feem ntau cov enzyme inhibitors khi rau qhov chaw nquag ntawm cov enzyme thiab tiv thaiv kev tsim cov enzyme-substrate complex. Yog li ntawd, tus inhibitor sib tw nrog lub substrate rau khi nrog lub active site ntawm lub enzyme. Yog tias ib qho enzyme tsis khi nrog lub substrate, nws cov kev ua haujlwm catalytic txo. Li no, thaum kawg ntawm cov tshuaj tiv thaiv, tus nqi ntawm cov khoom yog tsawg. Qhov tseeb, tus nqi ntawm cov khoom tsim yog inversely proportional rau concentration ntawm inhibitor molecules.
Daim duab 01: Enzyme Inhibitor
Kev khi ntawm ib qho inhibitor rau ib qho enzyme tuaj yeem thim rov qab lossis hloov tsis tau. Reversible inhibitors khi tsis-covalently nrog cov enzyme, tsim hydrogen bonds, hydrophobic kev sib raug zoo thiab ionic bonds thaum irreversible inhibitors khi covalently. Irreversible inhibitors hloov cov enzyme tshuaj los ntawm kev hloov kho nws cov amino acid ib ntus. Thaum cov amino acid sequence hloov, nws cov haujlwm txo. Ntau hom tshuaj yog enzyme inhibitors, tshwj xeeb tshaj yog cov tshuaj tiv thaiv kab mob siv los kho HIV.
Enzyme Inducer yog dab tsi?
Enzyme inducer yog ib qho molecule uas ua rau kom cov catalytic kev ua haujlwm ntawm ib qho enzyme. Nws tuaj yeem ntxias cov enzyme los ntawm kev khi nrog nws qhov chaw ua haujlwm thiab txo cov enzyme degradation tus nqi. Nws kuj tseem tuaj yeem ua rau kev nthuav tawm ntawm cov noob uas encodes cov enzyme kom nce tag nrho cov enzyme koom nrog hauv cov tshuaj tiv thaiv. Yog li, enzyme inducer nce cov synthesis ntawm cov enzyme los ntawm kev ua kom cov noob qhia.
Daim duab 02: Rifampin: ib qho Enzyme Inducer
Ntau xenobiotics thiab ib puag ncig cov tshuaj yog enzyme inducers. Ntau cov tshuaj kuj yog enzyme inducers. Rifampin yog ib qho tshuaj tiv thaiv kab mob TB uas yog ib qho enzyme inducer nrov. Ntxiv mus, carbamazepine, phenytoin thiab phenobarbital yog ob peb lwm enzyme inducers.
Dab tsi zoo sib xws ntawm Enzyme Inhibitor thiab Enzyme Inducer?
- Enzyme inducer thiab enzyme inhibitor tuaj yeem hloov pauv tus nqi ntawm enzyme kev ua haujlwm.
- Lawv tuaj yeem khi nrog qhov chaw nquag ntawm cov enzyme.
- Ntau yam tshuaj yog enzyme inhibitors thiab enzyme inducers.
- Ob hom tseem ceeb hauv kev tshawb fawb ntawm cov tshuaj metabolism.
Qhov txawv ntawm Enzyme Inhibitor thiab Enzyme Inducer yog dab tsi?
Enzyme inhibitor yog ib qho molecule uas txo cov kev ua ntawm ib qho enzyme los ntawm kev khi nrog qhov chaw nquag ntawm cov enzyme thaum lub enzyme inducer yog ib qho molecule uas ua rau kom cov metabolism hauv cov enzyme los ntawm kev khi rau nws lossis los ntawm kev nce cov noob. kev qhia. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm enzyme inhibitor thiab enzyme inducer.
Ntxiv mus, enzyme inhibitor txo cov khoom lag luam thaum enzyme inducer nce cov khoom lag luam. Yog li, qhov no yog lwm qhov sib txawv ntawm enzyme inhibitor thiab enzyme inducer.
Summary – Enzyme Inhibitor vs Enzyme Inducer
Enzyme inhibitors yog cov molecules uas khi nrog cov enzymes thiab txo cov enzymes. Hauv qhov sib piv, enzyme inducers yog cov molecules uas ua rau muaj kev ua haujlwm ntawm enzyme. Inducers txo qhov degradation ntawm cov enzymes. Qee cov inducers nce qhov kev qhia ntawm cov noob uas yog lub luag haujlwm rau kev sib txuas. Yog li ntawd, qhov kev txiav txim ntawm enzyme inhibitor txo cov nqi ntawm cov khoom thaum qhov kev txiav txim ntawm enzyme inducer nce tus nqi ntawm cov khoom thaum kawg. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm enzyme inhibitor thiab enzyme inducer.
