Qhov sib txawv tseem ceeb ntawm Gattermann thiab Gattermann Koch cov tshuaj tiv thaiv yog Gattermann cov tshuaj tiv thaiv siv cov tshuaj sib xyaw ntawm hydrogen cyanide thiab hydrochloric acid, thaum Gattermann Koch cov tshuaj tiv thaiv siv carbon monoxide es tsis txhob siv hydrogen cyanide.
Gattermann Koch cov tshuaj tiv thaiv yog qhov hloov pauv ntawm Gattermann cov tshuaj tiv thaiv. Lub tshuab ntawm Gattermann cov tshuaj tiv thaiv tau tshawb pom los ntawm German kws tshawb fawb Ludwig Gattermann thaum lub tswv yim ntawm Gattermann Koch cov tshuaj tiv thaiv tau tsim los ntawm Ludwig Gattermann thiab Julius Koch.
Gattermann Reaction yog dab tsi?
Gattermann cov tshuaj tiv thaiv yog cov tshuaj tiv thaiv kev hloov pauv hauv cov organic uas peb tuaj yeem tsim cov tshuaj tsw qab. Nws yog lub npe hu ua German chemist Ludwig Gattermann. Tsis tas li ntawd, cov tshuaj tiv thaiv no tuaj yeem tshwm sim nyob rau hauv lub xub ntiag ntawm Lewis acid catalysts. Tsis tas li ntawd, lub formylation yog ua tiav los ntawm kev sib xyaw ntawm HCN (hydrogen cyanide) thiab HCl (hydrochloric acid). Lewis acid catalyst peb siv feem ntau yog AlCl3
Tsis tas li ntawd, kom yooj yim, peb tuaj yeem hloov HCN / HCl sib tov los ntawm zinc cyanide. Tom qab ntawd, txoj kev no yuav muaj kev nyab xeeb dua vim tias zinc cyanide tsis muaj tshuaj lom zoo li HCN. Ntxiv mus, nws tseem ceeb heev uas yuav tsum nco ntsoov tias Gattermann cov tshuaj tiv thaiv tseem ceeb hauv kev qhia cov pab pawg aldehyde rau lub nplhaib benzene.
Daim duab 01: Gattermann Aldehyde Synthesis
Vim tias daim ntawv thov tseem ceeb ntawm cov tshuaj tiv thaiv no yog tsim cov tshuaj tsw qab, peb tuaj yeem hu nws ua Gattermann formylation; Qee zaum peb hu nws ua Gattermann salicylaldehyde synthesis. Tsis tas li ntawd, qhov tshuaj tiv thaiv no zoo ib yam li Friedel-Craft cov tshuaj tiv thaiv.
Gattermann Koch Reaction yog dab tsi?
Gattermann Koch cov tshuaj tiv thaiv yog qhov hloov pauv ntawm Gattermann cov tshuaj tiv thaiv, thiab cov tshuaj tiv thaiv no suav nrog kev siv cov pa roj carbon monoxide es tsis txhob siv hydrogen cyanide (HCN). Yog li, tsis zoo li Gattermann cov tshuaj tiv thaiv, peb tsis tuaj yeem siv Gattermann Koch cov tshuaj tiv thaiv rau phenol thiab phenol ether substrates.
Daim duab 02: Gattermann Koch Reaction
Tsis tas li ntawd, cov tshuaj tiv thaiv no feem ntau siv zinc chloride ua cov catalyst, thiab nws yuav tsum muaj cov kab mob ntawm tooj liab (I) chloride ua co-catalyst.
Dab tsi yog qhov txawv ntawm Gattermann thiab Gattermann Koch Reaction?
Gattermann Koch cov tshuaj tiv thaiv yog qhov hloov pauv ntawm Gattermann cov tshuaj tiv thaiv. Gattermann cov tshuaj tiv thaiv yog ib qho kev hloov pauv ntawm cov organic uas peb tuaj yeem tsim cov tshuaj tsw qab. Gattermann Koch cov tshuaj tiv thaiv yog qhov hloov pauv ntawm Gattermann cov tshuaj tiv thaiv thiab koom nrog kev siv cov pa roj carbon monoxide es tsis txhob siv hydrogen cyanide (HCN). Yog li ntawd, qhov sib txawv tseem ceeb ntawm Gattermann thiab Gattermann Koch cov tshuaj tiv thaiv yog Gattermann cov tshuaj tiv thaiv siv cov tshuaj sib xyaw ntawm hydrogen cyanide thiab hydrochloric acid, thaum Gattermann Koch cov tshuaj tiv thaiv siv carbon monoxide es tsis txhob siv hydrogen cyanide.
Tsis tas li ntawd, Gattermann Koch cov tshuaj tiv thaiv feem ntau siv zinc chloride ua cov catalyst, thiab nws yuav tsum muaj cov kab mob tooj liab (I) chloride ua cov co-catalyst. Txawm li cas los xij, hauv Gattermann cov tshuaj tiv thaiv, cov catalyst feem ntau yog txhuas chloride. Sib nrug ntawm qhov ntawd, tsis zoo li Gattermann cov tshuaj tiv thaiv, peb tsis tuaj yeem siv Gattermann Koch cov tshuaj tiv thaiv rau phenol thiab phenol ether substrates.
Hauv qab infographic qhia qhov txawv ntawm Gattermann thiab Gattermann Koch cov tshuaj tiv thaiv.
Summary – Gattermann vs Gattermann Koch Reaction
Gattermann Koch cov tshuaj tiv thaiv yog qhov hloov pauv ntawm Gattermann cov tshuaj tiv thaiv. Qhov sib txawv tseem ceeb ntawm Gattermann thiab Gattermann Koch cov tshuaj tiv thaiv yog Gattermann cov tshuaj tiv thaiv siv cov tshuaj sib xyaw ntawm hydrogen cyanide thiab hydrochloric acid, thaum Gattermann Koch cov tshuaj tiv thaiv siv carbon monoxide es tsis txhob siv hydrogen cyanide. Gattermann cov tshuaj tiv thaiv tau raug hu ua tom qab tus kws tshawb fawb German Ludwig Gattermann thaum Gattermann Koch cov tshuaj tiv thaiv tau muab npe tom qab ob tus kws tshawb fawb, Julius Koch thiab Ludwig Gattermann.
