Qhov sib txawv tseem ceeb ntawm Fluconazole thiab Itraconazole yog tias txawm tias ob qho tib si yog cov tshuaj tiv thaiv kab mob, fluconazole tsis ua haujlwm tawm tsam Aspergillus thaum Itraconazole tawm tsam Aspergillus. Yog li ntawd, itraconazole muaj ntau yam kev ua ub no tshaj fluconazole.
Lub npe lag luam ntawm fluconazole yog Diflucan, thiab lub npe lag luam ntawm itraconazole yog Sporanox.
Fluconazole yog dab tsi?
Fluconazole yog tshuaj tua kab mob rau kev kho cov kab mob fungal xws li candidiasis, blastomycosis, coccidiooidomycosis, cryptococcosis, histoplasmosis, dermatophytosis, thiab pityriasis versicolor. Cov tshuaj formula ntawm fluconazole yog C13H12F2N6O, thiab molar mass yog 306.27 g / mol. Lub melting point yog nyob ib ncig ntawm 138-140 ° C.
Daim duab 01: Lub cev pob txha ntawm Fluconazole
Fluconazole poob rau hauv chav kawm ntawm azoles, uas yog cov tshuaj tua kab mob. Txawm li cas los xij, nws txawv ntawm lwm cov tshuaj tua kab mob azole los ntawm kev muaj lub nplhaib triazole es tsis txhob siv lub nplhaib imidazole (xws li lwm cov azoles). Tsis tas li ntawd, fluconazole yog siv rau qhov ncauj (tsis zoo li imidazole antifungals). Fluconazole ua haujlwm zoo tshaj plaws tiv thaiv kab mob Candida, qee cov kab mob dimorphic, thiab dermatophytes.
Side Effects:
Cov kev mob tshwm sim ntawm fluconazole muaj xws li ua pob liab vog, mob taub hau, kiv taub hau, xeev siab, raws plab, thiab lwm yam. Qee cov kev mob tshwm sim tsis tshua muaj xws li oliguria, qaug dab peg, alopecia, daim siab tsis ua haujlwm, thiab lwm yam. Muaj cov teebmeem tsis tshua muaj tshwm sim thiab. Piv txwv li: ncua QT ncua sij hawm.
Itraconazole yog dab tsi?
Itraconazole yog tshuaj tua kab mob los kho cov kab mob fungal xws li aspergillosis, blastomycosis, coccidiooidomycosis, histoplasmosis, thiab paracoccidioidomycosis. Txoj kev ntawm kev tswj hwm yog qhov ncauj lossis IV (intravenously). Tshwj xeeb, cov tshuaj no muaj txiaj ntsig zoo hauv kev kho mob Aspergillus. Ntxiv mus, cov kev tshawb fawb tsis ntev los no tau pom tias cov tshuaj no muaj cov tshuaj tiv thaiv kab mob ib yam nkaus.
Cov tshuaj formula ntawm Itraconazole yog C35H38Cl2N 8O4, thiab molar mass yog 705.24 g / mol. Nws muaj cov qauv tshuaj nyuaj heev. Qhov no qhia tau hais tias chirality; yog li ntawd muaj nyob raws li ib tug racemic sib tov. Lub melting point ntawm Itraconazole yog 170 ° C.
Daim duab 02: Cov Qauv Tshuaj ntawm Itraconazole
Side Effects:
Cov kev mob tshwm sim ntawm Itraconazole suav nrog xeev siab, ntuav, raws plab, ua pob, thiab mob taub hau. Muaj qee qhov tsis tshua muaj tshwm sim ib yam nkaus; Cov kev mob tshwm sim muaj xws li nce qib alanine aminotransferase, congestive plawv tsis ua hauj lwm, siab tsis ua hauj lwm, thiab lwm yam.
Qhov txawv ntawm Fluconazole thiab Itraconazole yog dab tsi?
YFluconazole vs Itraconazole |
|
| Fluconazole yog tshuaj tua kab mob feem ntau siv los kho cov kab mob los ntawm Candida hom, qee cov kab mob dimorphic, thiab dermatophytes. | Itraconazole yog tshuaj tua kab mob feem ntau siv los kho aspergillosis thiab blastomycosis. |
| tshuaj formula | |
| C13H12F2N6 O. | C35H38Cl2N8 O4 |
| Molar Mass | |
| 306.27 g/mol. | 705.24 g/mol. |
| Melting Point | |
| Around 138-140°C. | 170°C. |
| Kev Tiv Thaiv Kab Mob Aspergillus | |
| Tsis tawm tsam Aspergillus. | Active tiv thaiv Aspergillus. |
| pob khaus, mob taub hau, kiv taub hau, xeev siab, raws plab, thiab lwm yam. | xeev siab, ntuav, raws plab, tawm pob, thiab mob taub hau. |
Summary – Fluconazole vs Itraconazole
Fluconazole thiab Itraconazole yog ob yam tshuaj tiv thaiv kab mob tseem ceeb. Qhov sib txawv tseem ceeb ntawm fluconazole thiab Itraconazole yog qhov fluconazole tsis nquag tawm tsam Aspergillus whereas itraconazole yog nquag tawm tsam Aspergillus.
