Qhov sib txawv tseem ceeb ntawm pawg ntseeg thiab pawg neeg quenching yog qhov kev paub ntawm pawg ntseeg yog ib txoj cai tswj hwm cov noob caj noob ces siv los ntawm cov kab mob sib txuas lus thiab paub txog lawv cov xov tooj ntawm tes ntom ntom, thaum pawg pawg quenching yog cov txheej txheem ntawm cov kab mob uas ua haujlwm tawm tsam. Pawg neeg soj ntsuam thiab nres cov kab mob virulence gene qhia.
Cov kab mob siv cov txheej txheem sib txawv los sib txuas lus. Cov txheej txheem kev sib txuas lus no pab kom lawv hnov cov pej xeem ceev, thiab tswj ntau yam ntawm lawv cov txheej txheem physiological. Quorum sensing yog ib qho zoo li no siv los ntawm cov kab mob hnyav heev. Quorum sensing tsis tsuas yog pab txhawb kev sib txuas lus thiab paub cov pej xeem ceev, tab sis nws kuj ua lub luag haujlwm tseem ceeb hauv kev tswj cov kab mob ntawm cov kab mob ntawm lwm tus tswv xws li tib neeg. Txawm li cas los xij, quorum sensing mechanisms muaj teeb meem hauv kev tswj cov kab mob. Raws li kev daws teeb meem, pawg quenching tuaj yeem siv tau. Quorum quenching cuam tshuam rau pawg neeg paub cov kab mob thiab kaw qhov kev qhia ntawm cov kab mob pathogenic.
Qhaurum Sensing yog dab tsi?
Quorum sensing yog ib txoj kev tswj cov noob caj noob ces siv los ntawm cov kab mob. Lawv siv cov txheej txheem no los sib txuas lus nrog cov kab mob hlwb thiab paub txog lawv tus kheej cov pejxeem. Lawv tsim thiab tso cov molecules me me hu ua autoinducers kom nkag siab cov pej xeem ceev. Siv cov qauv no, lawv tswj cov kev qhia ntawm cov kab mob virulence. Ntxiv mus, autoinducers yog me me diffusible signaling molecules, feem ntau N-acyl-homoserine lactones (AHL). Lawv ua rau kev nthuav tawm ntawm cov noob kab mob phem.
Daim duab 01: Pawg Neeg Saib Xyuas
Quorum sensing yog ib qho tseem ceeb rau ntau lub cev kev ua ub no ntawm cov kab mob. Quorum sensing molecules induce processes xws li symbiosis, virulence, competence, conjugation, antibiotic production, motility, sporulation, nitrogen fixation and biofilm formation, etc.
Tsis tas li ntawd, qhov kev paub ntawm pawg neeg muaj ntau nyob hauv cov kab mob gram-negative thiab gram-positive. Txawm li cas los xij, lawv secrete txawv molecules li autoinducers. Cov kab mob Gram-negative mediate quorum sensing los ntawm acylated homoserine lactones thaum cov kab mob gram-zoo kho nws los ntawm cov txheej txheem oligo-peptides.
Qhaurum Quenching yog dab tsi?
Quorum quenching yog ib qho txheej txheem ntawm cov kab mob uas ua haujlwm tawm tsam pawg neeg paub txog cov kab mob. Thaum quorum sensing pab cov kab mob los qhia cov kab mob virulence, quorum quenching inhibits nws. Yog li, quorum quenching yog ib txoj hauv kev uas kaw cov kab mob virulence gene qhia hauv cov kab mob pathogenic. Hauv quorum quenching, cov kab mob tsim cov enzymes thiab tshuaj inhibitors kom degrade quorum sensing molecules. Thaum degradation ntawm autoinducers, cov kab mob poob lawv lub peev xwm ntawm pawg neeg paub. Yog li ntawd, pawg pawg quenching cuam tshuam lub peev xwm ntawm cov kab mob kom nkag siab txog nws cov xov tooj ntawm tes thiab ua tsis taus lossis txo qis lub peev xwm ua rau muaj qhov tsis zoo.
Daim duab 02: Pawg Quenching
Quorum quenching nres pawg ntseeg los ntawm ntau txoj hauv kev. Nws inactivates signaling enzymes los yog qhia cov molecules uas mimic signaling molecules thiab blocks lawv receptors. Tsis tas li ntawd, quenching enzymes degrade signaling molecules los yog hloov quorum sensing signals.
Vim hais tias pawg neeg quenching yog ib qho txheej txheem ntuj tsim, nws tuaj yeem tsim los ua ib txoj hauv kev los tiv thaiv kab mob microbial. Cov kab mob sib txuas lus yog ib qho tseem ceeb ntawm kev kis kab mob. Yog li ntawd, quorum quenching yuav yog ib qho kev cog lus rau kev cuam tshuam cov kab mob sib txuas lus, yog li tiv thaiv kab mob. Yog li, pawg quenching tuaj yeem txhais tau yooj yim raws li daim ntawv ntawm kev tiv thaiv kab mob.
Dab tsi yog qhov Zoo sib xws ntawm Pawg Saib Xyuas thiab Pawg Quenching?
- Ob lub tswv yim no tau pom tsuas yog hauv cov kab mob.
- Lawv kuj yog cov txheej txheem ntuj tshwm sim hauv cov kab mob.
- Ntxiv mus, ob txheej txheem tsim cov enzymes, tshuaj, thiab lwm yam los kho cov txheej txheem.
Qhov txawv ntawm Pawg Neeg Saib Xyuas thiab Pawg Quenching yog dab tsi?
Quorum sensing yog txheej txheem uas cov kab mob siv los sib txuas lus thiab paub txog lawv cov pejxeem. Qhov sib txawv, pawg pawg quenching yog ib txheej txheem uas cov kab mob siv los cuam tshuam pawg neeg paub. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm pawg sensing thiab pawg quenching.
Ntxiv mus, lwm qhov sib txawv tseem ceeb ntawm pawg ntseeg thiab pawg ntseeg quenching yog cov kab mob zais autoinducers lossis pawg pom cov teeb liab hauv pawg sensing, thaum cov kab mob tsim cov enzymes thiab quorum sensing inhibitors hauv pawg quenching.
Hauv qab infographic muab kev sib piv ntau ntxiv hais txog qhov sib txawv ntawm pawg ntseeg thiab pawg ntseeg quenching.
Summary – Quorum Sensing vs Quorum Quenching
Quorum sensing thiab quorum quenching yog ob lub ntuj tsim los ntawm cov kab mob. Quorum sensing pab txhawb kev sib txuas lus ntawm cov kab mob thiab paub txog lawv cov pejxeem. Nws tshwm sim ntawm me me molecules hu ua autoinducers. Nws yog ib qho tseem ceeb ntawm cov kab mob vim nws pab nyob rau hauv symbiosis, virulence, muaj peev xwm, conjugation, tshuaj tua kab mob ntau lawm, motility, sporulation, nitrogen fixation thiab biofilm tsim, thiab lwm yam. Lub caij no, pawg pawg quenching ua haujlwm tawm tsam pawg neeg paub. Nws cuam tshuam rau pawg neeg paub txog thiab kaw cov kab mob virulence gene qhia. Yog li ntawd, nws yog ib tug anti-virulence mechanism. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm pawg ntseeg thiab pawg ntseeg quenching.
