Qhov sib txawv tseem ceeb ntawm motif thiab domain yog tias lub motif tsis nyob ntawm nws tus kheej ruaj khov thaum lub npe nws tus kheej ruaj khov.
Proteins yog ib qho tseem ceeb lom macromolecules nyob rau hauv peb lub cev. Ntawm qhov tod tes, cov cai ntawm cov noob caj noob ces yuav txiav txim siab cov amino acid ib ntus ntawm cov protein. Tsis tas li ntawd, cov proteins muaj lub hauv paus, theem nrab thiab qib theem. Cov qauv tseem ceeb yog cov amino acid sib lawv liag ntawm cov saw polypeptide. Thaum polypeptide chains quav nrog ib leeg, nws tsim cov qauv thib ob ntawm cov protein. Alpha helices, beta sheets thiab super-secondary structures yog nyob rau cov qauv thib ob. Qee pawg ntawm super-secondary ntsiab yog hu ua protein motifs. Cov qauv tertiary ntawm cov protein yog hais txog nws cov qauv peb sab uas txiav txim siab ua haujlwm ntawm cov protein. Domain yog ib feem folded ntawm cov protein molecule, uas yog globular thiab muaj ib tug discrete muaj nuj nqi. Nws yog qhov tseem ceeb ua haujlwm thiab peb-seem qauv ntawm cov protein.
Motif yog dab tsi?
Motif yog ib pawg ntawm cov ntsiab lus thib ob ntawm cov protein xws li alpha helices thiab beta qauv. Lawv yog ib co qauv uas muaj nyob rau hauv txawv proteins. Motifs piav txog cov qauv folding ntawm cov txheej txheem thib ob thiab lawv cov kev sib cuam tshuam. Cov qauv folding no ruaj khov los ntawm cov kev sib txuas zoo sib xws uas muaj nyob hauv cov qauv tertiary. Txawm li cas los xij, lawv tsis nyuaj li cov qauv tertiary.
Daim duab 01: Motif
Lawv yog kev sib txuas yooj yim ntawm cov txheej txheem thib ob ntawm cov proteins. Motif tsis ruaj khov ntawm nws tus kheej. Tsis tas li ntawd, motifs piav qhia txog cov qauv ntawm cov protein tab sis tsis kwv yees ua haujlwm ntawm cov protein. Piv txwv ntawm cov motifs protein yog beta-alpha-beta motif, Greek key motif, Beta chim, Beta-meander motif, thiab lwm yam.
Domain yog dab tsi?
Domain yog ib qho tseem ceeb, ua haujlwm thiab peb seem ntawm cov protein. Nws ua ib qho haujlwm tshwj xeeb. Ib qho protein ntau tuaj yeem muaj ntau qhov sib txawv. Txhua tus sau yog ib qho kev ywj pheej. Nws yog ib tug globular qauv. Nws yog lub luag haujlwm rau ib qho haujlwm tshwj xeeb lossis kev sib cuam tshuam. Domains tuaj yeem siv los ua kev xav txog kev ua haujlwm ntawm cov protein tsis muaj txiaj ntsig. Thaum txheeb xyuas cov protein, nws yog ib qho tseem ceeb uas yuav tsum tau coj mus rau hauv tus account vim cov thawj yog cov haujlwm ua haujlwm ntawm cov protein.
Daim duab 02: Peb Qhov Sib Txawv ntawm Pyruvate Kinase
Domains yog qhov ruaj khov thiab cov qauv tsim. Lawv tuaj yeem yooj yim txawv ntawm lwm thaj chaw. Pyruvate kinase muaj peb qhov sib txawv raws li qhia hauv daim duab 02. Qhov ntev ntawm lub npe tuaj yeem sib txawv, thiab qhov nruab nrab ntev yog 100 amino acids. Txhua tus sau muaj cov tub ntxhais hydrophobic ua los ntawm cov chav tsev theem nrab. Ob peb lub koom ua ke ua cov qauv tertiary ntawm cov protein.
Qhov Zoo sib xws ntawm Motif thiab Domain yog dab tsi?
- Motif thiab domain yog cov chav nyob hauv cov protein molecules lawv tus kheej.
- Lawv muaj txiaj ntsig thaum faib cov tsev neeg protein.
Qhov txawv ntawm Motif thiab Domain yog dab tsi?
Motif yog ib pawg ntawm cov ntsiab lus tseem ceeb ntawm cov proteins xws li alpha helices thiab beta cov qauv thaum domain yog lub luag haujlwm ntawm cov protein. Tsis tas li ntawd, motif yog tus qauv thib ob thaum lub luag haujlwm yog lub luag haujlwm rau tertiary qauv ntawm cov protein. Ntxiv mus, domain yog ib qho kev ywj pheej, tsis zoo li lub motif. Tsis tas li ntawd, sau piav qhia txog kev ua haujlwm ntawm cov protein thaum motif tsis yog. Cov no yog qhov sib txawv tseem ceeb ntawm motif thiab domain. Cov infographic hauv qab no nthuav tawm qhov sib txawv ntawm motif thiab domain hauv daim ntawv tabular.
Summary – Motif vs Domain
Motif yog ib qho kev npaj ntawm cov txheej txheem thib ob ntawm cov protein molecule. Nws tsis yog feem ntau ruaj khov ntawm nws tus kheej, tsis zoo li tus sau. Domain yog tus qauv ruaj khov ntawm cov protein. Yog li ntawd, nws tuaj yeem yog ib feem lossis tag nrho cov protein molecule. Nws yog peb qhov tseem ceeb hauv kev ua haujlwm ntawm cov protein. Ntxiv mus, nws muaj lub luag haujlwm, thiab nws yog ib qho kev ywj pheej. Motif tuaj yeem yog ib feem ntawm lub npe. Tab sis tus sau tsis tuaj yeem yog ib feem ntawm lub motif. Qhov no yog qhov txawv ntawm motif thiab domain.
