Qhov sib txawv tseem ceeb ntawm Parkinson's thiab myasthenia gravis yog tias txawm hais tias myasthenia yog ib qho mob autoimmune uas yog vim kev tsim cov autoantibodies hauv lub cev, Parkinson tus kab mob tsis muaj autoimmune tivthaiv hauv nws pathogenesis.
Ob leeg Parkinson's thiab myasthenia gravis yog cov kab mob paj hlwb uas muaj kev cuam tshuam loj heev rau kev ua neej zoo ntawm tus neeg mob. Parkinson tus kab mob yog ib qho kev tsis sib haum xeeb uas tshwm sim los ntawm kev poob qis hauv qib dopamine ntawm lub hlwb. Myasthenia gravis, ntawm qhov tod tes, yog ib qho kab mob autoimmune uas tshwm sim los ntawm kev tsim cov tshuaj tiv thaiv kab mob uas thaiv kev sib kis ntawm impulses hla cov kab mob neuromuscular.
Parkinson's Disease yog dab tsi?
Ua ntej, Parkinson tus kab mob yog ib qho kev txav tsis zoo uas tshwm sim los ntawm kev poob qis hauv qib dopamine ntawm lub hlwb. Qhov ua rau ntawm tus mob no tseem muaj teeb meem. Txoj kev pheej hmoo ntawm tus kab mob Parkinson nce ntxiv nrog cov hnub nyoog siab heev.
Pathology
Lub ntsiab morphological hloov hauv Parkinson tus kab mob suav nrog cov tsos ntawm Lewy lub cev thiab poob ntawm dopaminergic neurons nyob rau hauv pars compacta ntawm substantia nigra cheeb tsam ntawm lub midbrain.
Tshuaj Kho Mob
- Slow txav (bradykinesia/akinesia)
- Ntxhais tremor
- Kev hais lus ntsiag to, tsis paub meej thiab tiaj tus
- Nyob rau hauv kev tshuaj ntsuam xyuas, tuaj yeem txheeb xyuas cov yeeb nkab ua kom nruj ntawm cov ceg
- Tus neeg mob kuj tuaj yeem txhim kho kev paub tsis meej nyob rau theem kawg ntawm tus kab mob
Daim duab 01: Parkinson's Disease
Diagnosis
Tsis muaj chaw kuaj xyuas kom paub tseeb tias tus kab mob Parkinson. Yog li, kev kuaj mob tsuas yog nyob ntawm cov cim qhia thiab cov tsos mob pom tau thaum lub sijhawm kuaj mob. Ntxiv mus, MRI cov duab yuav zoo li qub feem ntau ntawm lub sijhawm.
Kev kho mob
Kev qhia tus neeg mob thiab tsev neeg yog qhov tseem ceeb. Cov tshuaj xws li dopamine receptor agonists thiab levodopa, uas rov ua haujlwm dopamine ntawm lub hlwb, tuaj yeem txo cov tsos mob ntawm lub cev. Nws tseem yog ib qho tseem ceeb los tswj kev pw tsaug zog thiab kev puas siab puas ntsws kom tsim nyog.
Dopamine antagonists xws li neuroleptics tuaj yeem ua rau Parkinson tus kab mob zoo li cov tsos mob, nyob rau hauv rooj plaub no, lawv raug hu ua Parkinsonism.
Myasthenia Gravis yog dab tsi?
Myasthenia gravis yog ib qho kab mob autoimmune uas tshwm sim los ntawm kev tsim cov tshuaj tiv thaiv kab mob uas thaiv kev sib kis ntawm impulses hla cov kab mob neuromuscular. Cov tshuaj tiv thaiv no khi rau postsynaptic Ach receptors, tiv thaiv kev khi ntawm Ach hauv synaptic cleft rau cov receptors. Cov poj niam muaj tsib zaug cuam tshuam los ntawm tus mob no ntau dua li txiv neej. Kuj tseem muaj kev koom tes tseem ceeb nrog rau lwm yam kab mob autoimmune xws li mob caj dab rheumatoid, SLE, thiab autoimmune thyroiditis.
Tshuaj Kho Mob
- Tsis muaj zog ntawm cov leeg nqaij limb, cov leeg sab nraud, thiab cov leeg pob txha
- muaj zog thiab hloov pauv ntawm cov leeg tsis muaj zog
- Tsis mob leeg
- Reflexes kuj fatigable
- Diplopia, ptosis, thiab dysphagia
- Nws tsis cuam tshuam rau lub plawv, tab sis tuaj yeem cuam tshuam rau cov leeg ua pa
Kev tshawb nrhiav
- Anti ACh receptor antibodies hauv cov ntshav
- Tensilon kuaj qhov twg kev tswj hwm ntawm koob tshuaj edrophonium ua rau muaj kev txhim kho ib ntus ntawm cov tsos mob uas kav ntev li 5 feeb
- Kev Tshawb Fawb
- ESR and CRP
Kev tswj hwm
- Kev tswj hwm ntawm anticholinesterases xws li pyridostigmine
- Yuav muab cov tshuaj tiv thaiv kab mob xws li corticosteroids rau cov neeg mob uas tsis teb rau cov tshuaj anticholinesterases
- YThymectomy
- Plasmapheresis
- YIntravenous immunoglobulins
Qhov txawv ntawm Parkinson's thiab Myasthenia Gravis yog dab tsi?
Parkinson tus kab mob yog ib qho kev tsis sib haum xeeb uas tshwm sim los ntawm kev poob qis hauv dopamine theem ntawm lub hlwb thaum myasthenia gravis yog ib qho kab mob autoimmune uas tshwm sim los ntawm kev tsim cov tshuaj tiv thaiv kab mob uas thaiv kev sib kis ntawm impulses hla lub neuromuscular hlws ris. Myasthenia gravis yog kab mob autoimmune tab sis Parkinson's tsis suav tias yog kab mob autoimmune. Qhov no yog qhov sib txawv tseem ceeb ntawm Parkinson's thiab myasthenia gravis. Qhov tshwm sim ntawm Lewy lub cev thiab poob ntawm dopaminergic neurons nyob rau hauv pars compacta ntawm substantia nigra cheeb tsam ntawm midbrain yog cov kev hloov morphological hauv Parkinson tus kab mob. Nyob rau hauv sib piv, qhov thaiv ntawm kev sib kis ntawm lub paj hlwb impulses ntawm lub neuromuscular hlws ris vim qhov kev txiav txim ntawm autoantibodies yog lub hauv paus pathological ntawm myasthenia gravis.
Tsis tas li ntawd, tsis muaj kev sim kuaj xyuas qhov tseeb ntawm tus kab mob Parkinson. Txawm li cas los xij, kev tshawb nrhiav xws li Anti ACh receptor antibodies hauv cov ntshav, tensilon test, imaging studies, ESR thiab CRP tuaj yeem pab kuaj mob myasthenia gravis. Tsis tas li ntawd, anticholinesterases xws li pyridostigmine, tshuaj tiv thaiv kab mob xws li corticosteroids, Thyctomy, Plasmapheresis thiab intravenous immunoglobulins tuaj yeem pab tswj myasthenia gravis. Ntawm qhov tod tes, cov tshuaj xws li dopamine receptor agonists thiab levodopa, uas rov ua haujlwm dopamine ntawm lub hlwb, tuaj yeem txo cov tsos mob ntawm Parkinson's.
Summary – Parkinson's vs Myasthenia Gravis
Parkinson's thiab myasthenia gravis yog cov kab mob paj hlwb uas muaj kev cuam tshuam loj heev rau kev ua neej zoo ntawm tus neeg mob. Qhov sib txawv tseem ceeb ntawm Parkinson's thiab myasthenia gravis yog lawv cov tshuaj tiv thaiv kab mob autoimmune.
