Qhov Tseem Ceeb Qhov txawv - EPSP vs IPSP
Lub paj hlwb tseem ceeb thaum teb rau cov stimuli sib txawv tau txais los ntawm cov paj hlwb. Ob qho tib si lom thiab electrochemical Cheebtsam koom nrog cov teeb liab kis tau los ntawm lub paj hlwb. Muaj peev xwm sib txawv uas tsim nyob rau hauv lub paj hlwb ua rau kev sib kis ntawm cov paj hlwb sib txawv. Cov peev xwm zoo li no suav nrog cov peev txheej tau qhab nia, kev ua tau zoo thiab cov peev txheej so thiab lwm yam. Tag nrho cov peev txheej no tshwm sim vim muaj kev hloov pauv ntawm electrochemical uas tshwm sim. Tawm ntawm cov peev txheej sib txawv, qhov muaj peev xwm muab qhab nia yog tsim los ntawm cov khoom sib txawv xws li qeeb yoj muaj peev xwm, receptor muaj peev xwm, cov peev xwm pacemaker thiab cov peev txheej tom qab synaptic. EPSP thiab IPSP yog ob hom kev muaj peev xwm tom qab kev sib tham. EPSP stands rau excitatory post-synaptic muaj peev xwm thiab IPSP stands rau inhibitory post-synaptic muaj peev xwm. Hauv cov ntsiab lus yooj yim, EPSP tsim lub xeev excitable ntawm post-synaptic membrane uas muaj peev xwm tua hluav taws muaj peev xwm thaum IPSP tsim lub xeev tsis txaus siab uas txwv tsis pub tua hluav taws ntawm kev ua haujlwm los ntawm post-synaptic membrane. Qhov no yog qhov txawv ntawm EPSP thiab IPSP.
EPSP yog dab tsi?
EPSP raug xa mus rau qhov muaj peev xwm ua rau tom qab synaptic. Nws yog ib qho hluav taws xob uas tshwm sim nyob rau hauv lub post-synaptic daim nyias nyias ntawm cov neuron vim excitatory neurotransmitters. Nws induces tiam ntawm qhov kev txiav txim muaj peev xwm. Hauv lwm lo lus, EPSP yog qhov kev npaj ntawm post-synaptic membrane los tua qhov muaj peev xwm ua tau. Lub cim ntawm ib qho kev muaj peev xwm los ntawm post-synaptic membrane tshwm sim los ntawm cov txheej txheem ua ntu zus nrog kev koom tes ntawm cov neurotransmitters sib txawv thiab ligand-gated ion channels. Cov neurotransmitters uas yog excitatory tso tawm los ntawm vesicles ntawm pre-synaptic membrane thiab nkag mus rau hauv lub post-synaptic membrane.
Cov neurotransmitter loj uas nkag mus rau tom qab synaptic membrane yog glutamate. Aspartate ions kuj tuaj yeem ua raws li kev ua kom muaj zog neurotransmitter. Thaum nkag mus, cov neurotransmitters khi rau cov receptors ntawm post-synaptic membrane. Kev khi ntawm neurotransmitters ua rau qhib cov ligand-gated ion channels. Qhov qhib ntawm ligand-gated ion channels ua rau cov ndlwg ntawm cov ions zoo, feem ntau yog sodium ions (Na+), mus rau tom qab-synaptic membrane.
Daim duab 01: EPSP
Qhov kev txav ntawm cov ions zoo li no ua rau lub cev depolarization ntawm post-synaptic membrane. Hauv lwm lo lus, EPSP tsim ib qho chaw zoo siab nyob rau hauv lub post-synaptic membrane. Qhov kev zoo siab no ua rau muaj kev tawm tsam ntawm qhov muaj peev xwm ua tau los ntawm kev coj mus rau tom qab-synaptic membrane mus rau theem pib.
IPSP yog dab tsi?
IPSP raug xa mus rau qhov inhibitory post-synaptic peev xwm. Nws yog ib qho hluav taws xob nqi uas tsim nyob rau hauv lub post-synaptic membrane inhibiting firing ntawm ib tug tej yam kev ua. Qhov no yog qhov txawv ntawm EPSP. Qhov laj thawj tseem ceeb rau kev txhim kho IPSP yog cov txheej txheem ua ntu zus uas cuam tshuam nrog inhibitory neurotransmitters khi rau post-synaptic membrane receptors. Cov neurotransmitters no suav nrog Glycine thiab Gamma-Amino Butyric Acid (GABA), uas tau zais los ntawm cov ntaub ntawv ua ntej synaptic. GABA yog ib qho amino acid uas ua raws li qhov muaj feem ntau inhibitory neurotransmitter hauv nruab nrab paj hlwb. Thaum tso tawm, GABA khi rau receptors xws li GABAA thiab GABAB tam sim no nyob rau hauv post-synaptic membrane. Thaum cov inhibitory neurotransmitters khi, nws ua rau qhib ligand-gated ion channels uas ua rau lub zog ntawm chloride ions (Cl-) mus rau hauv lub post-synaptic membrane.
Cov kab ke gated no feem ntau hu ua ligand-gated chloride ion channels. Cov tshuaj chloride ions raug them tsis zoo. Cov ions no ua rau hyperpolarization ntawm post-synaptic membrane. Qhov no txhais tau hais tias ISPS tsim ib puag ncig uas muaj qhov tsis tshua muaj tshwm sim ntawm kev tua hluav taws. Cov txheej txheem inhibitory no txuas ntxiv mus txog thaum lub inhibitory neurotransmitters detach los ntawm cov receptors ntawm post-synaptic membrane uas lawv tau khi rau. Thaum tshem tawm, cov neurotransmitters yuav poob rov qab mus rau lawv qhov chaw qub uas ua rau kaw ligand-gated chloride ion channels. Tsis muaj chloride ions yuav nkag mus rau tom qab synaptic membrane, thiab daim nyias nyias yuav nkag mus rau hauv lub xeev muaj peev xwm sib npaug.
Qhov Zoo sib xws ntawm EPSP thiab IPSP yog dab tsi?
- Ob leeg yog qhov muaj peev xwm tom qab synaptic thiab tshwm sim hauv post-synaptic membrane.
- Ob leeg yog kho los ntawm ligand-gated ion channels.
- Nyob rau hauv ob qho tib si, ligand-gated ion channels qhib los ntawm kev khi ntawm cov khoom sib txawv neurotransmitter molecules.
Qhov txawv ntawm EPSP thiab IPSP yog dab tsi?
EPSP vs IPSP |
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| EPSP yog tus nqi hluav taws xob uas tshwm sim nyob rau hauv post-synaptic membrane raws li qhov tshwm sim ntawm excitatory neurotransmitters thiab induces tiam ntawm ib qho kev ua muaj peev xwm. | IPSP yog tus nqi hluav taws xob uas tshwm sim nyob rau hauv post-synaptic daim nyias nyias raws li kev khi ntawm cov tsis muaj excitatory lossis inhibitory neurotransmitters thiab tiv thaiv cov tiam ntawm kev ua haujlwm. |
| hom polarization | |
| Depolarization tshwm sim thaum lub sijhawm EPSP. | Hyperpolarization tshwm sim thaum lub sij hawm IPSP. |
| feeb | |
| EPSP coj cov kab mob tom qab synaptic mus rau theem pib thiab ua rau muaj peev xwm ua tau. | IPSP qhia cov kab mob tom qab synaptic deb ntawm qib pib thiab tiv thaiv kev tsim cov peev txheej. |
| Hom Ligands Koom Tes | |
| Glutamate ions thiab aspartate ions koom nrog thaum lub sijhawm EPSP. | Glycine thiab Gamma-Aminobutyric acid (GABA) tau koom nrog thaum lub sijhawm IPSP. |
Summary – EPSP vs IPSP
EPSP raug xa mus rau qhov ua rau muaj peev xwm postsynaptic excitatory. Nws yog ib qho hluav taws xob uas tshwm sim nyob rau hauv lub post-synaptic daim nyias nyias ntawm cov neuron vim excitatory neurotransmitters. EPSP tsim ib qho chaw zoo siab nyob rau hauv lub post-synaptic membrane. Qhov kev zoo siab no ua rau muaj kev tua hluav taws. IPSP yog hu ua inhibitory postsynaptic peev xwm. Nws yog ib qho hluav taws xob uas tau tsim nyob rau hauv lub post-synaptic daim nyias nyias uas inhibits qhov firing ntawm lub peev xwm ua. Qhov laj thawj tseem ceeb rau kev txhim kho ntawm IPSP yog cov txheej txheem ua ntu zus uas cuam tshuam nrog inhibitory neurotransmitters, uas yog khi rau tom qab synaptic membrane receptors. Cov txheej txheem inhibitory no txuas ntxiv mus txog thaum lub inhibitory neurotransmitters tshem tawm ntawm cov receptors. Qhov no yog qhov txawv ntawm EPSP thiab IPSP.
Download PDF ntawm EPSP vs IPSP
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