Qhov Tseem Ceeb Qhov txawv - Interchromosomal vs Intrachromosomal Recombination
DNA recombination yog txheej txheem uas kev sib pauv ntawm cov khoom siv caj ces tshwm sim ntawm cov chromosomes sib txawv lossis thaj chaw sib txawv ntawm tib chromosome. Qhov no yog hu ua interchromosomal recombination thiab intrachromosomal recombination feem. Interchromosomal recombination tuaj yeem txhais tau tias yog hom caj ces recombination qhov twg cov kab ke ntawm nucleotides sib pauv ntawm ob qho tib si molecules ntawm DNA los yog homologous chromosomes thaum intrachromosomal recombination tshwm sim vim hla ntawm ob kab txuas txuas ntawm tib chromosomes. Qhov no yog qhov sib txawv tseem ceeb ntawm interchromosomal thiab intrachromosomal recombination.
Interchromosomal Recombination yog dab tsi?
Interchromosomal recombination tshwm sim los ntawm kev ywj pheej assortment. Kev ywj pheej assortment yog txheej txheem uas cov noob sib txawv ntawm nws tus kheej sib cais los ntawm ib leeg thaum lub sij hawm kev loj hlob ntawm cov qe menyuam. Interchromosomal recombination kuj tseem hu ua homologous recombination. Hauv lwm cov ntsiab lus, interchromosomal recombination tuaj yeem txhais tau tias yog hom kev sib txuas ntawm caj ces uas cov kab ke ntawm nucleotides sib pauv ntawm ob lub molecules zoo tib yam ntawm DNA lossis homologous chromosomes. Interchromosomal recombination nquag koom nrog hauv kev kho kom raug ntawm ob-strand so (DSBs). DSBs yog kev puas tsuaj uas tshwm sim ntawm ob qho tib si ntawm DNA molecule.
Interchromosomal recombination yog txheej txheem tseem ceeb uas tshwm sim nyob rau hauv cov kab mob mammalian uas nws tsim cov kev sib txawv tshiab ntawm DNA sequences. Qhov kev loj hlob ntawm cov kab ke tshiab no tshwm sim thaum lub sij hawm meiosis qhov twg cov kab mob eukaryotic ua gamete hlwb uas suav nrog cov phev thiab qe qe. Interchromosomal recombination uas ua rau muaj kev ywj pheej ntawm cov khoom siv caj ces txhim kho caj ces hloov pauv hauv cov xeeb ntxwv vim muaj kev sib xyaw DNA tshiab. Induction ntawm cov kev hloov pauv no los ntawm interchromosomal recombination muab kev tiv thaiv txaus rau cov kab mob kom yoog raws thiab muaj sia nyob hauv ib qho tshwj xeeb thiab tseem ua lub luag haujlwm tseem ceeb hauv cov ntsiab lus ntawm evolution. Tsis yog rau kev ywj pheej nkaus xwb, tab sis interchromosomal recombination kuj tseem siv tau rau kev hloov cov noob kab rov tav qhov twg kev sib pauv ntawm cov khoom siv caj ces tshwm sim ntawm ntau hom thiab hom kab mob uas muaj cov kab mob thiab kab mob. Interchromosomal recombination qhia txog kev siv tshuaj lom neeg thoob ntiaj teb txij li nws tau txiav txim siab raws li kev khaws cia thoob plaws peb qhov tseem ceeb ntawm cov ntawv ua neej suav nrog cov kab mob.
YIntrachromosomal Recombination yog dab tsi?
Intrachromosomal recombination tseem hu ua non-homologous recombination uas plays lub luag haujlwm tseem ceeb hauv cov tsiaj txhu tsiaj txhu. Nws yog tshwm sim los ntawm kev hla ntawm ob qhov sib txuas gene khub ntawm ob lub chromosomes uas tsis yog homologous. Intrachromosomal recombination ua rau muaj kev kho mob sib txawv hauv lub cev mammalian. Nws tau pom tias kev loj hlob ntawm ntau cov qog nqaij hlav metastatic yog vim qhov sib txuam ntawm cov qauv sib txawv ntawm intrachromosomal recombination. Intrachromosomal recombination feem ntau tshwm sim thaum hloov DNA mus rau hauv cov hlwb mammalian. Qhov no intrachromosomal los yog non-homologous recombination tshwm sim nyob rau hauv random genomic sites. Tab sis txawm tias ntau qhov kev tshawb fawb tau ua tiav ntawm qhov no, cov kws tshawb fawb tau ua tsis tiav qhov kev nkag siab zoo ntawm cov txheej txheem ntawm intrachromosomal recombination uas tshwm sim ntawm qhov chaw genomic.
Kev hloov pauv ntawm DNA ib ntus xws li T cell receptor rearrangement, immunoglobulin receptor rearrangement, retroviral integration, transposition thiab retrotransposition yog yooj yim thiab ua tiav los ntawm intrachromosomal recombination. Thaum lub sijhawm qee qhov tshwm sim ntawm kev sib koom ua ke no, kev koom tes ntawm kev hloov pauv ob txoj hlua khi (DSB) tshwm sim.
Daim duab 01: Mammalian ob-strand break (DSB) kho los ntawm Intrachromosomal Recombination
Zoo ib yam li interchromosomal recombination, intrachromosomal recombination kuj tseem koom nrog hauv kev kho kom raug ntawm DSBs. Intrachromosomal recombination txheej txheem muaj ib lub tswv yim tshwj xeeb los kho cov DSBs vim DSBs muaj peev xwm ua kom tuag taus yog tias lawv tsis kho nrog cov txheej txheem tsim nyog. Breakage fusion choj voj voog (BFBC) yog ib txoj hauv kev tseem ceeb ntawm kev kho uas raug ntxias los ntawm intrachromosomal recombination txheej txheem los kho somatic chromosomal DSBs. Yog li ntawd, intrachromosomal recombination yog suav hais tias yog ib qho tseem ceeb hauv cov ntsiab lus ntawm ntau yam phenomena uas tshwm sim nyob rau hauv lub mammalian systems.
Dab tsi yog qhov zoo sib xws ntawm Interchromosomal thiab Intrachromosomal Recombination?
Ob leeg koom nrog kho qhov tseeb ntawm DSBs ntawm DNA
Qhov txawv ntawm Interchromosomal thiab Intrachromosomal Recombination yog dab tsi?
Interchromosomal vs Intrachromosomal Recombination |
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| Interchromosomal recombination yog ib hom kev sib txuas ntawm caj ces uas cov kab ke ntawm nucleotides sib pauv ntawm ob lub molecules zoo tib yam ntawm DNA. | Intrachromosomal recombination yog tshwm sim los ntawm kev hla ntawm ob txoj kab txuas txuas ntawm ob lub chromosomes uas tsis yog homologous. |
| tshwm sim | |
| Interchromosomal recombination tshwm sim ntawm cov noob ntawm cov chromosomes sib txawv. | Intrachromosomal recombination tshwm sim ntawm cov noob ntawm tib chromosome. |
| Homologous recombination yog ib lub ntsiab lus rau interchromosomal recombination. | Non-homologous recombination yog ib lub ntsiab lus rau intrachromosomal recombination. |
Summary – Interchromosomal vs Intrachromosomal Recombination
DNA recombination yog txheej txheem uas kev sib pauv ntawm cov khoom siv caj ces tshwm sim ntawm ntau yam chromosomes lossis ntau thaj tsam ntawm tib chromosome. Interchromosomal recombination yog ib hom genetic recombination qhov twg cov sequences ntawm nucleotides pauv ntawm ob zoo tib yam molecules ntawm DNA ntawm zoo tib yam los yog homologous chromosomes. Nws tshwm sim los ntawm kev ywj pheej assortment. Nws tuaj yeem siv rau kev hloov cov noob kab rov tav uas qhov kev sib pauv ntawm cov khoom siv caj ces tshwm sim ntawm ntau hom thiab hom kab mob. Intrachromosomal recombination tseem hu ua non-homologous recombination. Nws yog tshwm sim los ntawm kev hla ntawm ob qhov txuas gene khub ntawm ob lub chromosomes uas tsis yog homologous. Ob leeg inter thiab intrachromosomal recombination nquag koom nrog kev kho kom raug ntawm DSBs.
Download PDF Version ntawm Interchromosomal vs Intrachromosomal Recombination
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Interchromosomal thiab Intrachromosomal Recombination (1)
