Qhov Tseem Ceeb Qhov txawv - Nicotinic vs Muscarinic Receptors
Kev sib koom tes paj hlwb yog ua raws li kev sib kis ntawm cov paj hlwb impulses. Cov neurotransmitters sib txawv tau koom nrog hauv kev xa paj hlwb. Acetylcholine yog ib qho ntawm cov neurotransmitter koom nrog hauv lub paj hlwb. Muaj ob lub ntsiab ntawm receptors nyob rau hauv uas acetylcholine ua raws li agonist. Ob lub ntsiab acetylcholine receptors yog Nicotinic Receptors thiab Muscarinic receptors. Acetylcholine khi rau cov receptors thiab xa cov cim ntawm cov receptors. Nicotinic receptors yog acetylcholine receptors uas agonist yog nicotine, thiab yog ligand-gated ion channels. Muscarinic receptors yog acetylcholine receptors uas muscarine ua tus agonist, thiab lawv yog G protein-coupled receptors. Qhov sib txawv tseem ceeb ntawm nicotinic thiab muscarinic receptors yog tias Nicotinic receptors yog ligand-gated ion channels, whereas Muscarinic receptors yog G protein-coupled receptors.
Nicotinic Receptors yog dab tsi?
Nicotinic Receptors muaj npe raws li lawv cov agonist tshwj xeeb uas yog nicotine. Nicotine yog lub active compound ntawm luam yeeb. Nicotine yog ib qho alkaloid thiab muaj ntau yam kev cuam tshuam neuro thaum tswj hwm kev ua neej nyob. Nicotinic receptors yog ligand-gated ion channels. Lawv muaj nyob hauv cov pores hauv cov ntshav plasma, thiab yog li, lawv tau koom nrog kev sib kis ceev ceev synaptic.
Nicotinic acetylcholine receptors koom nrog ntau yam haujlwm uas nyob ntawm qhov chaw ntawm cov receptor. Cov leeg nqaij hom nicotinic receptors yog nyob ntawm neuromuscular junctions. Lawv yog lub luag haujlwm rau kev sib koom tes ntawm cov leeg nqaij uas suav nrog ob qho tib si contractions thiab so. Neuronal nicotinic receptors nyob rau hauv nruab nrab ntawm cov neurons thiab koom nrog ntau yam kev ua haujlwm nrog rau kev nco, kev kawm, kev tswj lub cev muaj zog thiab tshuaj loog.
Qhov kev txiav txim ntawm nicotinic receptors yog coj los ntawm kev khi ntawm acetylcholine rau cov receptor. Thaum khi cov nicotinic receptor, nws hloov pauv thiab ua kom cov permeability ntawm sodium thiab calcium ions rau hauv plasma membrane. Qhov no ua kom yooj yim rau depolarization thiab excitation uas ua rau muaj kev ntxhov siab.
Daim duab 01: Nicotinic Receptor Structure
Muaj tsib hom subunits ntawm Nicotinic Acetylcholine receptors (AChRs) uas yog alpha (a1-a10), beta (b2-b5), delta, epsilon, thiab gamma. Kev sib xyaw ua ke ntawm saum tsib subunits tuaj yeem pom nyob rau hauv ntau hom nicotinic receptors. Nicotinic receptors tau txais cov qauv pentameric. Nws yog tsim los ntawm Acetylcholine binding site uas yog ib qho alpha dimer thiab ib qho subunit uas nyob ib sab uas yog qhov sib ntxiv subunit.
Dab tsi yog Muscarinic Receptors?
Muscarinic receptors lossis muscarinic acetylcholine receptors yog lub npe los ntawm nws cov agonist ntxiv uas yog muscarine. Muscarine yog ib qho alkaloid tau los ntawm cov nceb hu ua Amanita muscaria. Qhov no yog dej-soluble toxin thiab khi rau muscarinic receptors thiab tuaj yeem ua rau tuag taus.
-Cov tshuaj uas muaj cov tshuaj lom neeg yog g protein-coupled receptors thiab ua kom cov neeg xa xov hauv theem theem mus rau hauv lub xovtooj rau ntawm tes los pab txhawb cov hlab ntaws. Thaum khi ntawm acetylcholine rau muscarinic receptor, G protein-coupled cov tshuaj tiv thaiv cascade yog qhib. Txij li thaum lub receptor yog G protein-coupled protein, cov txheej txheem kis tau tus mob qeeb. Muscarinic receptors koom nrog ntau yam haujlwm uas suav nrog kev cog lus thiab so ntawm cov leeg, tswj lub plawv dhia thiab tso tawm ntau yam neurotransmitters.
Daim duab 02: Muscarinic Receptors
Muaj tsib lub ntsiab subtypes ntawm muscarinic receptors, thiab lawv tau sau tias yog M1, M2, M3, M4, thiab M5. Tag nrho tsib muscarinic receptors muaj nyob rau hauv lub hauv paus paj hlwb. Thiab M1-M4 muaj nyob rau hauv lwm hom ntaub so ntswg thiab. M1 Acetylcholine receptors tuaj yeem pom muaj nyob rau hauv cov qog qog nqaij hlav thaum M2 Acetylcholine receptors feem ntau pom hauv cov ntaub so ntswg. M3 Acetylcholine receptors muaj nyob rau hauv cov leeg nqaij thiab cov qog ua kua. M1, M3, thiab M5 receptors ua rau kev ua haujlwm ntawm phospholipase C, ua rau kev nce hauv cellular ntawm calcium, thaum M2 thiab M4 inhibit adenylate cyclase.
Dab tsi zoo sib xws ntawm Nicotinic thiab Muscarinic Receptors?
- Ob lub receptors yog acetylcholine binding receptors.
- Ob lub receptors muaj tsib-subunit qauv.
- Ob lub receptors muaj agonists uas yog alkaloids.
- Ob lub receptors nyob hauv lub hauv nruab nrab lub paj hlwb uas ua haujlwm ntau yam.
- Ob lub receptors koom nrog hauv cov hlab ntsha.
- Ob lub receptors muaj zog heev.
- Ob leeg yog cov protein receptors.
- Ob leeg yog cov proteins uas muaj nyob hauv daim nyias nyias.
Qhov txawv ntawm Nicotinic thiab Muscarinic Receptors yog dab tsi?
Nicotinic vs Muscarinic Receptors |
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| Nicotinic receptors yog cov receptors uas agonist yog nicotine, thiab yog ligand-gated ion channels uas neurotransmission tau yooj yim. | Muscarinic receptors yog acetylcholine receptors uas muscarine ua tus agonist, thiab lawv yog G protein-coupled receptors. |
| Agonists | |
| Nicotine ua tus agonist rau Nicotinic receptor. | Muscarine ua tus agonist rau Muscarinic receptor. |
| Yam tus txais | |
| Nicotinic receptors yog ligand-gated ion channels. | Muscarinic receptors yog G protein-coupled receptors. |
| Ceev ntawm Nerve Transmission | |
| Nicotinic receptors kho kom nrawm nrawm nrawm ntawm cov neurotransmitter. | Muscarinic receptors kho cov lus teb qeeb metabolic ntawm tus xa xov thib ob. |
Summary – Nicotinic vs Muscarinic Receptors
Nervous receptors ua lub luag haujlwm tseem ceeb hauv kev xa cov teeb liab ntawm lub paj hlwb. Lub ntsiab neurotransmitter (Acetylcholine) khi rau ob lub ntsiab receptors. Lawv yog cov nicotinic receptors thiab muscarinic receptors. Lawv muaj npe raws li cov agonists uas khi rau cov receptors. Nicotine khi rau nicotinic receptors, thiab muscarine khi rau muscarinic receptors. Lawv koom nrog ntau yam haujlwm uas ua rau cov paj hlwb impulse kis tau los ntawm kev sib kis ntawm synaptic. Nicotinic receptors yog ligand-gated raws uas kho kom haum rau kev sib kis ceev ceev ntawm cov neurotransmitter. Muscarinic receptors yog G protein-coupled receptors kho cov lus teb qeeb metabolic ntawm tus tub txib thib ob. Qhov no yog qhov txawv ntawm nicotinic thiab Muscarinic receptors.
Download PDF Version ntawm Nicotinic vs Muscarinic Receptors
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