Qhov Tseem Ceeb - Chylomicrons vs VLDL
Nyob rau hauv cov ntsiab lus ntawm kev thauj mus los ntawm lipids hauv lub cev, lipoproteins yog cov molecules tseem ceeb hauv lub cev. Ib qho lipoprotein yog suav tias yog biochemical aggregation uas yog tsim los ntawm lipids thiab proteins. Cov qauv ntawm lipoproteins muaj cov monolayer ntawm phospholipids thiab cov roj cholesterol thiab cov proteins tau kos rau hauv nws. Hauv cov txheej txheem roj cholesterol sab nrauv, cov cheeb tsam hydrophilic yog nyob rau sab nraud, thiab thaj chaw hydrophobic (lipophilic) yog rau sab hauv. Muaj plaub hom lipoproteins loj; chylomicrons, low-density lipoprotein (VLDL), low-density lipoprotein (LDL) thiab high-density lipoprotein (HDL). Chylomicron yog lipoprotein loj tshaj plaws ntawm plaub hom. VLDL muaj peev xwm hloov nws cov qauv mus rau ntau hom lipoproteins. Chylomicrons yog synthesized nyob rau hauv cov hnyuv me, thiab thauj exogenous khoom noj khoom haus thaum VLDL synthesizes nyob rau hauv daim siab thiab thauj cov khoom noj khoom haus endogenous. Qhov no yog qhov sib txawv tseem ceeb ntawm chylomicrons thiab VLDL.
YChylomicrons yog dab tsi?
Chylomicrons yog suav tias yog cov lipoproteins uas muaj feem ntau ntawm triglycerides thiab tsawg feem ntawm cov proteins. Phospholipids thiab cholesterol muaj nyob rau hauv qhov nruab nrab. Lub luag haujlwm tseem ceeb ntawm chylomicrons yog kev thauj mus los ntawm kev noj zaub mov lipids uas tau nqus los ntawm cov hnyuv me mus rau ntau qhov chaw xws li cov rog rog ntawm cov ntaub so ntswg adipose, cov leeg plawv, thiab cov leeg pob txha. Ntawm qhov chaw sib txawv, triglyceride tivthaiv raug tshem tawm los ntawm chylomicrons vim yog kev ua haujlwm ntawm lipoprotein lipase thiab ua rau cov roj ntsha dawb kom nqus tau los ntawm cov ntaub so ntswg.
Chylomicrons yog keeb kwm nyob rau hauv endoplasmic reticulum ntawm cov enterocytes uas muaj nyob rau hauv cov kab mob ntawm cov hnyuv. Cov qauv ntawm txoj hnyuv yog tsim los rau kev nqus ntau dua vim qhov chaw siab ntawm qhov chaw muab los ntawm qhov muaj villi thiab microvilli. Cov chylomicrons tshiab tau tso tawm los ntawm basolateral daim nyias nyias mus rau hauv lub lacteals. Lacteal yog ib qho capillary ntawm lymphatic cov ntaub so ntswg uas absorbs cov rog ntawm cov villi ntawm cov hnyuv. Txij li thaum lawv tau tso rau hauv cov kua mis, lawv tau ua ke nrog cov qog ntshav thiab tsim mus rau hauv chyle uas yog cov kua dej uas muaj cov roj emulsified thiab lymph. Cov tsim chyle yog thauj mus rau hauv cov hlab ntsha rov qab los ntawm cov hlab ntsha lymphatic uas cov chylomicrons tau muab nkag rau hauv cov ntaub so ntswg nrog cov roj absorbed los ntawm kev noj haus.
Daim duab 01: Chylomicron
Lub neej voj voog ntawm chylomicrons tuaj yeem yog peb theem sib txawv; chylomicrons, paub tab chylomicrons, chylomicron seem. Nyob rau hauv thawj theem, cov kua tsib uas yog secreted los ntawm lub gallbladder thiab lub enzyme lipase, emulsify thiab hydrolyze lub triglycerides feem rau hauv ib tug sib tov ntawm monoglycerides thiab fatty acids. Qhov sib tov no ces dhau mus rau hauv enterocytes ntawm cov kab mob hauv cov hnyuv. Ntawm no cov sib tov yog rov esterified uas ua rau tsim ntawm triacylglycerol. Qhov no tsim triacylglycerol tom qab ntawd ua ke nrog ntau cov tebchaw xws li phospholipids, cholesterols thiab apolipoprotein B 48 hauv kev tsim cov chylomicrons nascent.
Ib tug chylomicron paub tab yog tsim thaum lub sij hawm cov ntshav uas cov nascent chylomicrons pauv cov khoom nrog siab ceev lipoproteins (HDL) xws li apolipoprotein C 2 (APOC2) thiab apolipoprotein E. A chylomicron seem yog tsim nrog rov qab los ntawm APOC2. mus rau HDL thaum lub khw muag khoom triglyceride tau muab faib tag.
VLDL yog dab tsi?
Hauv cov ntsiab lus ntawm lipoproteins, VLDL (Very Low Density Lipoprotein) yog ib qho ntawm plaub hom. Raws li lub npe qhia VLDL yog qhov ntom ntom lipoproteins tsawg heev uas txheeb ze rau qhov ntom ntawm cov dej ntxiv. VLDL yog tsim los ntawm lub siab los ntawm kev sib sau ntawm triglycerides, apolipoproteins, thiab cov roj cholesterol. Hauv cov hlab ntsha, VLDL tau hloov mus rau ntau hom lipoproteins xws li LDL (Low Density Lipoprotein) thiab IDL (Intermediate Density Lipoprotein). VLDL raug suav hais tias yog qhov tseem ceeb ntawm cov lipid thauj mechanism tam sim no nyob rau hauv. Lawv lub luag haujlwm tseem ceeb yog thauj cov triglycerides endogenous, cholesterol, phospholipids thiab cov roj cholesterol esters. Tsis tas li ntawd, lawv koom nrog kev thauj mus los ntev ntawm cov protein sib txawv uas yog cov tub txib hydrophobic intercellular.
Daim duab 02: VLDL
Cov metabolism ntawm VLDL zoo ib yam li cov chylomicrons. Triacylglycerol yog lub ntsiab lipid pom hauv VLDL. Hom VLDL tso tawm los ntawm lub siab yog hu ua Nascent VLDL uas muaj cov apolipoprotein C1, apolipoprotein E thiab apolipoprotein B100 nrog rau cov roj cholesterol, phospholipids thiab cholesterol esters. Thaum cov ntshav ncig, nascent VLDL yuav tau txais apolipoprotein C2 thiab apolipoprotein E. Ob lub tebchaw no yog pub dawb los ntawm HDL. Thaum tau txais, nascent VLDL hloov mus rau VLDL paub tab. Mature VLDL nyob rau hauv cov nqaij thiab cov nqaij adipose los ntawm kev sib cuag nrog lipoprotein lipase (LPL) uas emulsifies thiab tshem tawm triglycerides los ntawm VLDL los hais txog lub hom phiaj cia lossis siv los ua lub zog.
Thaum paub tab VLDL tuaj ntsib nrog HDL qhov twg apolipoprotein C2 raug xa rov qab mus rau HDL. HDL, nrog rau cov roj cholesterol hloov pauv cov protein (CTEP) HDL hloov cov roj cholesterol rau VLDL hauv kev sib pauv ntawm phospholipids thiab triglycerides. Vim tias cov txheej txheem no suav nrog kev ua haujlwm ntawm LPL thiab CTEP, cov molecular muaj pes tsawg leeg ntawm VLDL hloov pauv thiab hloov cov molecule mus rau lwm hom lipoprotein; IDL.
Dab tsi yog qhov zoo sib xws ntawm Chylomicrons thiab VLDL?
- Ob leeg koom nrog hauv kev thauj cov lipids hauv lub cev.
- Ob lub txheej txheem metabolism zoo ib yam nrog kev sib cuam tshuam ntawm HDL (apolipoprotein C2 thiab apolipoprotein E).
- Cov lipid tseem ceeb ntawm ob hom yog triacylglycerol.
Qhov txawv ntawm Chylomicrons thiab VLDL yog dab tsi?
Chylomicrons vs VLDL |
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| Chylomicron yog cov lipoprotein loj tshaj plaws uas tau tsim nyob rau hauv cov hnyuv me thiab thauj cov khoom noj khoom haus exogenous. | VLDL yog cov lipoproteins tsawg-density synthesized nyob rau hauv daim siab thiab thauj khoom endogenous diatary khoom. |
| Kev thauj mus los | |
| Chylomicrons thauj cov khoom noj khoom haus exogenous. | VLDL thauj cov khoom noj khoom haus endogenous. |
| Zoo ntawm Synthesis | |
| Chylomicrons yog tsim los ntawm txoj hnyuv | VLDL yog tsim los ntawm lub siab. |
Summary – Chylomicrons vs VLDL
Lipoproteins muaj plaub yam sib txawv. Lawv koom nrog hauv kev thauj mus los ntawm lipids hauv lub cev nrog kev sib sau ntawm cov protein. Chylomicrons yog synthesized nyob rau hauv cov hnyuv me, thiab thauj cov khoom noj khoom haus exogenous whilst VLDL synthesizes nyob rau hauv daim siab thiab thauj cov khoom noj khoom haus endogenous. VLDL muaj peev xwm hloov mus rau lwm hom lipoproteins xws li IDL. Ob leeg cov txheej txheem metabolism zoo ib yam li kev sib cuam tshuam ntawm HDL (apolipoprotein C2 thiab apolipoprotein E). Cov lipid tseem ceeb ntawm ob qho tib si chylomicrons thiab VLDL yog triacylglycerol. Qhov no yog qhov txawv ntawm Chylomicrons thiab VLDL.
Download the PDF Version of Chylomicrons vs VLDL
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Chylomicrons thiab VLDL
