Qhov Tseem Ceeb Qhov txawv - Lymphoma vs Non Hodgkin's Lymphoma
Cov kab mob qog nqaij hlav qog nqaij hlav hu ua lymphomas. Lawv yog cov muaj ntau yam mob qog noj ntshav uas qhov tshwm sim tau loj hlob sai nyob rau hauv ob peb lub xyoo dhau los, feem ntau yog vim qhov nce ntawm cov tshuaj tiv thaiv kab mob. Non-Hodgkin's lymphoma yog ib hom lymphomas uas nws pathogenesis tshwm sim los ntawm ntau yam etiological yam. Hodgkin's lymphoma yog lwm hom. Yog li, qhov sib txawv ntawm lymphoma thiab Non-Hodgkin's lymphoma tshwm sim los ntawm qhov tseeb tias lymphoma suav nrog Hodgkin's thiab Non-Hodgkin's lymphoma thiab Non-Hodgkin's lymphoma tsuas yog ib hom. Li no, ntawm no, peb tau tham txog qhov txawv ntawm Hodgkin's thiab Non-Hodgkin's lymphoma.
Lymphoma yog dab tsi?
Malignancies ntawm lymphoid system hu ua lymphomas. Lawv tuaj yeem tshwm sim ntawm txhua qhov chaw uas muaj cov ntaub so ntswg lymphoid. Nws yog 5th ntau tshaj plaws hauv ntiaj teb sab hnub poob. Tag nrho qhov tshwm sim ntawm lymphoma yog 15-20 ib 100000. Peripheral lymphadenopathy yog cov tsos mob tshaj plaws. Txawm li cas los xij, hauv li 20% ntawm cov neeg mob, lymphadenopathy ntawm thawj qhov chaw extranodal raug pom. Hauv cov neeg mob tsawg, cov tsos mob ntawm lymphoma txuam nrog B xws li poob phaus, ua npaws, thiab tawm hws tuaj yeem tshwm sim. Raws li WHO kev faib tawm, lymphomas tuaj yeem muab faib ua ob pawg xws li Hodgkin's lymphoma thiab Non-Hodgkin's lymphoma.
Hodgkin's Lymphoma yog dab tsi?
Qhov tshwm sim ntawm Hodgkin's lymphomas yog 3 rau 100000 nyob rau sab hnub poob ntiaj teb. Cov pawg dav no tuaj yeem raug faib ua pawg me li Classical HL thiab Nodular Lymphocyte-predominant HL. Nyob rau hauv Classical HL, uas suav txog 90-95% ntawm cov neeg mob, cov cim tseem ceeb yog Reed-Sternberg cell. Hauv Nodular Lymphocyte Predominant HL, "popcorn cell", ib qho txawv ntawm Reed-Sternberg tuaj yeem pom nyob rau hauv lub tshuab ntsuas.
Etiology
Epstein-Barr Virus (EBV) DNA tau pom nyob hauv cov ntaub so ntswg los ntawm cov neeg mob Hodgkin's lymphoma.
Daim duab 01: Vital Lymph Nodes ntawm lub cev
Tshuaj Kho Mob
Painless cervical lymphadenopathy yog qhov kev nthuav qhia ntau tshaj plaws ntawm HL. Cov qog no yog rubbery ntawm kev kuaj. Ib feem me me ntawm cov neeg mob tuaj yeem tshwm sim nrog hnoos vim yog mediastinal lymphadenopathy. Qee tus tuaj yeem tsim pruritus thiab haus dej cawv mob ntawm qhov chaw ntawm lymphadenopathy.
Kev tshawb nrhiav
- Chest X-ray rau mediastinal widening
- CT scan ntawm lub hauv siab, plab, plab, caj dab
- PET scan
- pob txha pob txha biopsy
- ntshav suav
Kev tswj hwm
Kev nce qib hauv kev kho mob tsis ntev los no tau txhim kho qhov kev cia siab ntawm tus mob no. Kev kho mob nyob rau theem pib ntawm tus kab mob muaj xws li 2-4 lub voj voog ntawm doxorubicin, bleomycin, vinblastine thiab dacarbazine, tsis ua kom tsis muaj menyuam, ua raws li irradiation, uas tau pom ntau dua 90% kho tus nqi.
kab mob siab heev tuaj yeem kho nrog 6-8 lub voj voog ntawm doxorubicin, bleomycin, vinblastine, thiab dacarbazine nrog rau kev kho mob.
Dab tsi yog Hodgkin's Lymphoma?
Raws li tau hais thaum pib, Tsis yog-Hodgkin Lymphomas yog ib hom lymphomas. Raws li WHO kev faib tawm, 80% ntawm Non-Hodgkin's lymphomas yog B-cell keeb kwm thiab lwm tus yog T-cell keeb kwm.
Etiology
- tsev neeg keeb kwm
- Human T-cell Leukemia Virus type-1
- YHelicobacter pylori
- YChlamydia psittaci
- EBV
- tshuaj tiv thaiv kab mob thiab kab mob
Pathogenesis
Thaum lub sijhawm sib txawv ntawm kev txhim kho lymphocyte, malignant clonal expansion ntawm lymphocytes tuaj yeem tshwm sim ua rau muaj ntau hom lymphomas. Kev ua yuam kev hauv chav kawm hloov lossis hloov cov noob rau immunoglobulin thiab T cell receptors yog cov kab mob ua ntej uas tom qab tau nce mus rau kev hloov pauv tsis zoo.
Type of NHL
- Follicular
- YLymphoplasmacytic
- Mantle cell
- Diffuse loj B cell
- Burkitt's
- Anaplastic
Daim duab 02: Intermediate Magnification Micrograph ntawm Mantle Cell Lymphoma ntawm Terminal Ileum
Tshuaj Kho Mob
Qhov kev nthuav qhia ntau tshaj plaws yog qhov tsis mob lymphadenopathy lossis cov tsos mob tshwm sim vim muaj kev cuam tshuam los ntawm cov qog ntshav qog ntshav.
Dab tsi yog qhov zoo sib xws ntawm Lymphoma thiab Non Hodgkin's Lymphoma?
Nyob rau hauv ob qho xwm txheej, cov kab mob malignancies tshwm sim hauv cov ntaub so ntswg lymphoid
Qhov txawv ntawm Lymphoma thiab Non Hodgkin's Lymphoma yog dab tsi?
Lymphomas tuaj yeem muab faib ua ob pawg xws li Hodgkin's thiab Non-Hodgkin's lymphomas. Raws li tsis yog Hodgkin's lymphomas tsuas yog ntau hom lymphomas, tsis muaj qhov sib txawv loj los tham; li no, peb tau muab piv rau qhov sib txawv ntawm Hodgkin's thiab Non-Hodgkin's lymphomas.
Qhov txawv ntawm Hodgkin's Lymphoma thiab Non-Hodgkin's Lymphoma yog dab tsi?
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma |
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| Feem ntau, cov no yog nyob rau hauv ib pawg axial ntawm cov nodes xws li lub ncauj tsev menyuam thiab mediastinal nodes. | Cov kab mob peripheral feem ntau yuav cuam tshuam los ntawm Non-Hodgkin lymphomas. |
| Muaj kev sib kis los ntawm kev sib txuas. | Tshuaj tsis sib cuag. |
| Extranodal Presentation | |
| Kev nthuav qhia Extranodal tsis tshua muaj. | Kev nthuav qhia Extranodal yog ib qho. |
| Tus Kab Mob Epstein Barr yog tus neeg sawv cev etiological tshaj plaws. |
Qhov ua rau ntau zaus yog,
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| Kev nthuav qhia kho mob | |
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Painless cervical lymphadenopathy yog qhov kev nthuav qhia ntau tshaj plaws ntawm HL. Cov qog no yog rubbery ntawm kev kuaj. Ib feem me me ntawm cov neeg mob tuaj yeem tshwm sim nrog hnoos vim yog mediastinal lymphadenopathy. Qee tus tuaj yeem tsim pruritus thiab mob cawv ntawm qhov chaw ntawm lymphadenopathy. |
Qhov kev nthuav qhia ntau tshaj plaws yog qhov tsis mob lymphadenopathy lossis cov tsos mob tshwm sim vim muaj kev cuam tshuam los ntawm cov qog ntshav qog ntshav. |
Summary – Lymphoma vs Non Hodgkin's Lymphoma
Lymphomas yog cov qog nqaij hlav qog nqaij hlav. Muaj ob pawg tseem ceeb ntawm lymphomas; Lawv yog Hodgkin lymphomas thiab Non-Hodgkin lymphomas. Qhov kev cia siab ntawm cov kab mob phem no nyob ntawm theem ntawm kev kis kab mob thiab cov hlwb ntawm keeb kwm.
