Qhov Tseem Ceeb Qhov txawv - Ntau Sclerosis vs Systemic Sclerosis
Ob leeg ntau yam sclerosis thiab kab mob sclerosis yog cov kab mob autoimmune uas nws pathogenesis tshwm sim los ntawm qhov tsis paub txog ib puag ncig thiab caj ces. Multiple Sclerosis yog ib qho mob autoimmune, T-cell mediated inflammatory kab mob cuam tshuam rau hauv nruab nrab paj hlwb whereas systemic sclerosis, los yog scleroderma, yog ib tug kab mob autoimmune multisystem nrog ib tug zuj zus daim duab kho mob. Qhov sib txawv tseem ceeb ntawm ntau yam sclerosis thiab kab mob sclerosis yog tias ntau yam sclerosis cuam tshuam tsuas yog hauv nruab nrab paj hlwb tab sis kab mob sclerosis yog kab mob ntau yam uas cuam tshuam yuav luag txhua lub cev hauv lub cev.
Ntau Sclerosis yog dab tsi?
Ntau Sclerosis yog ib qho mob autoimmune, T-cell mediated inflammatory kab mob cuam tshuam rau hauv nruab nrab paj hlwb. Ntau qhov chaw ntawm demyelination muaj nyob rau hauv lub hlwb thiab tus txha caj qaum. Qhov tshwm sim ntawm MS yog siab dua ntawm cov poj niam. MS feem ntau tshwm sim ntawm 20 thiab 40 xyoo. Qhov tshwm sim ntawm tus kab mob sib txawv raws li thaj chaw thaj chaw thiab haiv neeg keeb kwm yav dhau los. Cov neeg mob uas muaj MS yog raug rau lwm yam kab mob autoimmune. Ob qho tib si caj ces thiab ib puag ncig cuam tshuam rau lub pathogenesis ntawm tus kab mob. Peb qhov kev nthuav qhia ntau tshaj plaws ntawm MS yog optic neuropathy, hlwb qia demyelination, thiab txha caj qaum.
Pathogenesis
T cell-mediated inflammatory txheej txheem tshwm sim feem ntau nyob rau hauv cov teeb meem dawb ntawm lub hlwb thiab qaum qaum ua cov plaques ntawm demyelination. 2-10mm loj plaques feem ntau pom muaj nyob rau hauv cov hlab ntsha optic, periventricular cheeb tsam, corpus callosum, lub paj hlwb qia thiab nws cov kev sib txuas ntawm cerebellar thiab lub ncauj tsev menyuam qaum.
Nyob rau hauv MS, peripheral myelinated qab haus huv tsis cuam tshuam ncaj qha. Nyob rau hauv daim ntawv loj ntawm tus kab mob, kev puas tsuaj mus tas li axonal tshwm sim ua rau muaj kev tsis taus.
Daim duab 01: Ntau Sclerosis
Hom Ntau Yam Sclerosis
- Raws-remitting MS
- Secondary progressive MS
- Primary progressive MS
- Relapsing-progressive MS
Cov cim qhia thiab cov tsos mob
- Mob qhov muag txav
- me me fogging ntawm lub hauv paus tsis pom kev / xim desaturation / ntom ntom nti
- Txo kev vibration sensation thiab proprioception hauv ko taw
- Clumsy tes or limb
- Kev tsis ruaj khov hauv kev taug kev
- tso zis ceev thiab zaus
- Neuropathic mob
- Nyob
- Spasticity
- Kev nyuaj siab
- Kev sib deev tsis zoo
- Kub rhiab
Nyob rau hauv MS lig, cov tsos mob hnyav heev nrog optic atrophy, nystagmus, spastic tetraparesis, ataxia, paj hlwb cov tsos mob, pseudobulbar palsy, urinary incontinence thiab kev paub tsis meej tuaj yeem pom.
Diagnosis
Kev kuaj mob MS tuaj yeem ua tau yog tias tus neeg mob tau muaj 2 lossis ntau qhov kev tawm tsam cuam tshuam rau ntau qhov chaw ntawm CNS. MRI yog qhov kev tshawb nrhiav tus qauv siv rau kev pom zoo ntawm kev kuaj mob. Kev kuaj CT thiab CSF tuaj yeem ua tiav los muab cov pov thawj txhawb ntxiv rau kev kuaj mob yog tias tsim nyog.
Kev tswj hwm
Tsis muaj kev kho mob rau MS. Tab sis ob peb cov tshuaj immunomodulatory tau qhia los hloov kho cov txheej txheem ntawm inflammatory relapsing-remitting theem ntawm MS. Cov no yog hu ua Disease Modifying Drugs (DMDs). Beta-interferon thiab glatiramer acetate yog cov piv txwv ntawm cov tshuaj no. Sib nrug los ntawm kev kho tshuaj, kev ntsuas dav dav xws li kev kho lub cev, kev txhawb nqa tus neeg mob nrog kev pab los ntawm ntau pab pawg thiab kev ua haujlwm kho mob tuaj yeem txhim kho kev ua neej nyob ntawm tus neeg mob.
Kev Tshawb Fawb
Qhov kev cia siab ntawm ntau tus kab mob sclerosis txawv ntawm qhov tsis tuaj yeem kwv yees. Qhov siab MR lesion load ntawm qhov kev nthuav qhia thawj zaug, tus nqi rov qab siab dua, txiv neej poj niam txiv neej thiab kev nthuav qhia lig yog feem ntau cuam tshuam nrog qhov tsis zoo. Qee tus neeg mob tseem nyob hauv lub neej ib txwm tsis muaj kev xiam oob khab thaum qee tus tuaj yeem xiam oob khab.
Dab tsi yog Systemic Sclerosis?
Systemic sclerosis, uas tseem hu ua scleroderma. yog ib qho kab mob autoimmune multisystem nrog cov duab kho mob zuj zus.
Risk Factors
Xov xwm rau
- YVinyl chloride
- silica plua plav
- Trichloroethylene
Tshuaj Kho Mob
- tawv tawv dhau lub ntsej muag, qhov ncauj me me, beak qhov ntswg thiab telangiectasia
- Dysmotility lossis strictures ntawm esophagus
- Scleroderma thiab lub raum teebmeem
- Pulmonary hypertension lossis pulmonary fibrosis
- Malabsorption, hypomotility ntawm txoj hnyuv thiab fecal incontinence
- Raynaud's phenomenon
Kev tshawb nrhiav
- Cov ntshav suav tag nrho - cov ntshav suav tag nrho feem ntau qhia pom muaj tus kabmob normochromic, normocytic anemia.
- Urea thiab electrolytes - urea thiab electrolyte theem tuaj yeem nce siab hauv scleroderma-koom nrog raum raug mob
- Kev kuaj rau cov tshuaj tiv thaiv xws li ACA thiab ANA uas feem ntau pom hauv cov kab mob sclerosis
- Urine microscopy
- Imaging
- X-ray lub hauv siab - qhov no tuaj yeem siv los tshem tawm lwm yam kab mob uas yuav muaj cov duab kho mob zoo sib xws. Ntxiv rau qhov no tuaj yeem pab tau los txheeb xyuas qhov txawv txav ntawm lub plawv lossis lub ntsws hloov pauv.
- X-ray ntawm ib txhais tes - qhov no tuaj yeem qhia cov calcium uas tau khaws cia nyob ib puag ncig cov pob txha ntawm cov ntiv tes.
- GI endoscopy tuaj yeem qhia qhov txawv txav hauv txoj hlab pas
- Kev daws teeb meem siab CT tuaj yeem ua tiav txhawm rau txheeb xyuas qhov kev cuam tshuam ntawm lub ntsws fibrotic
Daim duab 02: Pulmonary Fibrosis hauv Systemic Sclerosis
Kev tswj hwm
Tsis muaj kev kho mob rau cov kab mob sclerosis. Es tsis txhob, corticosteroids thiab immunosuppressants tau raug pov thawj tias tsis muaj txiaj ntsig zoo hauv kev tswj tus mob no. Ib txoj hauv kev tshwj xeeb hauv kev kho tus kab mob tuaj yeem pab tau kom tsis txhob muaj teeb meem mus sij hawm ntev uas cuam tshuam nrog cov kab mob sclerosis.
- Kev ntuas tus neeg mob thiab kev txhawb nqa tsev neeg tseem ceeb heev
- Kev siv cov roj nplaum ntawm daim tawv nqaij thiab kev tawm dag zog ntawm daim tawv nqaij tuaj yeem txwv txoj kev loj hlob ntawm kev cog lus
- Tsov sov sov thiab qhov ncauj vasodilators tuaj yeem siv los tswj Raynaud cov nyhuv
- Proton twj tso kua mis inhibitors feem ntau yog muab tshuaj los txo cov tsos mob ntawm txoj hlab pas
- ACE inhibitors yog cov tshuaj xaiv hauv kev tswj lub raum tsis zoo
- Pulmonary hypertension yuav tsum tau kho nrog lub qhov ncauj vasodilators, oxygen, thiab warfarin
Kev Tshawb Fawb
Tus kab mob me me muaj qhov pom zoo dua li tus kab mob diffuse. Cov kab mob pulmonary fibrosis feem ntau yog qhov ua rau tuag ntawm cov neeg mob scleroderma.
Dab tsi yog qhov zoo sib xws ntawm Ntau Sclerosis thiab Systemic Sclerosis?
- Ob leeg ntau yam sclerosis thiab kab mob sclerosis yog kab mob autoimmune.
- Ob kab mob no tsis muaj qhov kho tau.
Qhov txawv ntawm Ntau Yam Sclerosis thiab Systemic Sclerosis yog dab tsi?
Multiple Sclerosis vs Systemic Sclerosis |
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| Ntau Sclerosis yog ib qho mob autoimmune, T-cell mediated inflammatory kab mob cuam tshuam rau hauv nruab nrab paj hlwb. | Systemic sclerosis (scleroderma) yog ib qho kab mob autoimmune multisystem nrog cov duab kho mob zuj zus zuj zus. |
| Risk Factors | |
| Poj niam los txiv neej thiab caj ces predisposition yog qhov tseem ceeb paub. | raug rau Vinyl chloride, silica plua plav, rapeseed roj, thiab trichlorethylene yog qhov muaj feem cuam tshuam. |
| Tshuaj kho mob | |
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Tus kab mob thaum ntxov yog tus yam ntxwv ntawm kev kho mob hauv qab no. · Mob ntawm qhov muag txav · me me fogging ntawm lub hauv paus tsis pom kev / xim desaturation / ntom ntom nti · Txo kev vibration sensation thiab proprioception hauv ko taw · Clumsy tes or limb · Kev tsis khov ntawm kev taug kev · tso zis ceev thiab zaus · Neuropathic mob · Fatigue · Spasticity · Kev nyuaj siab · Kev sib deev dysfunction · Kub rhiab heev Thaum MS lig, cov tsos mob hnyav tuaj yeem pom nrog
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Cov tawv nqaij tawv nyob rau ntau thaj tsam ntawm lub cev yog qhov pom tseeb tshaj plaws hauv kev kho mob. Ntxiv rau qhov ntawd, cov yam ntxwv hauv qab no kuj tuaj yeem pom ntau zaus. · Ntws daim tawv nqaij ntawm lub ntsej muag, lub qhov ncauj me, beak qhov ntswg thiab telangiectasia · Dysmotility lossis strictures ntawm esophagus · Myocardial fibrosis · Scleroderma thiab lub raum teebmeem · Pulmonary hypertension lossis pulmonary fibrosis · malabsorption, hypomotility ntawm txoj hnyuv thiab fecal incontinence · Raynaud's phenomenon |
| Diagnosis | |
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Cov kev tshawb fawb hauv qab no tau ua tiav rau kev kuaj mob ntawm ntau yam sclerosis nrog rau kev soj ntsuam ntawm tus kab mob. · suav ntshav tag nrho · Urea thiab electrolytes · Kev kuaj rau cov tshuaj tiv thaiv xws li ACA thiab ANA uas feem ntau pom hauv cov kab mob sclerosis · tso zis microscopy · Chest X-ray · X-ray of a hand · GI endoscopy tuaj yeem pom qhov txawv txav hauv txoj hlab pas · Kev daws teeb meem CT tuaj yeem ua tiav txhawm rau txheeb xyuas qhov kev cuam tshuam ntawm lub ntsws fibrotic |
Cov kev ntsuas dav dav xws li kev kho lub cev, txhawb tus neeg mob nrog kev pab los ntawm ntau pab pawg thiab kev ua haujlwm kho mob tuaj yeem txhim kho kev ua neej nyob ntawm tus neeg mob. |
Kev tswj hwm lub hom phiaj ntawm kev tswj qhov hnyav ntawm cov tsos mob thiab ntes tus kabmob kis mus. · Kev ntuas tus neeg mob thiab kev txhawb nqa tsev neeg tseem ceeb heev · Kev siv cov roj nplaum ntawm daim tawv nqaij thiab kev tawm dag zog ntawm daim tawv nqaij tuaj yeem txwv txoj kev loj hlob ntawm kev cog lus · Tes sov so thiab qhov ncauj vasodilators tuaj yeem siv los tswj Raynaud cov nyhuv · Proton twj tso kua mis inhibitors feem ntau yog tshuaj los txo cov tsos mob ntawm esophageal · ACE inhibitors yog cov tshuaj xaiv hauv kev tswj lub raum tsis zoo · Pulmonary hypertension yuav tsum tau kho nrog lub qhov ncauj vasodilators, oxygen, thiab warfarin |
Summary – Ntau Sclerosis vs Systemic Sclerosis
Ntau Sclerosis yog ib qho mob autoimmune, T-cell mediated inflammatory kab mob cuam tshuam rau hauv nruab nrab paj hlwb qhov systemic sclerosis uas tseem paub tias scleroderma yog kab mob autoimmune multisystem nrog cov duab kho mob zuj zus. Qhov sib txawv tseem ceeb ntawm ntau yam sclerosis thiab kab mob sclerosis yog tias ntau yam sclerosis tsuas yog cuam tshuam rau hauv nruab nrab lub paj hlwb thaum lub cev sclerosis txuas nws cov txiaj ntsig yuav luag txhua lub cev ntawm lub cev.
Download PDF Version of Multiple Sclerosis vs Systemic Sclerosis
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Ntau Yam Sclerosis thiab Systemic Sclerosis
