Qhov Tseem Ceeb Qhov txawv - Ntau Sclerosis vs Motor Neuron Kab Mob
Ntau yam kab mob inflammatory tuaj yeem cuam tshuam rau hauv nruab nrab paj hlwb. Ntau Sclerosis yog cov kab mob neuroinflammatory feem ntau ntawm lawv. Lub cev muaj zog Neuron Disease (MND) yog ib qho mob neurodegenerative cuam tshuam rau CNS. Cov kab mob neurodegenerative yog tus cwj pwm los ntawm kev poob ntawm cov neurons. Cov kab mob no feem ntau pom thaum muaj hnub nyoog laus. Dementia thiab MND yog cov piv txwv ntawm cov kab mob neurodegenerative. Yog li, qhov sib txawv tseem ceeb ntawm ntau yam sclerosis thiab kab mob neuron lub cev muaj zog yog tias ntau yam sclerosis yog kab mob neuroinflammatory thaum MND yog kab mob neurodegenerative.
Dab tsi yog Motor Neuron Disease (MND)?
Motor neuron disease (MND) yog ib qho mob hnyav uas ua rau muaj kev qaug zog zuj zus thiab thaum kawg tuag vim ua pa tsis ua haujlwm lossis ua pa. Qhov tshwm sim txhua xyoo ntawm tus kab mob yog 2/100000, uas qhia tias tus kab mob no tsis tshua muaj tshwm sim. Hauv qee lub tebchaws, qhov teeb meem no raug txheeb xyuas tias yog Amyotrophic Lateral Sclerosis (ALS). Cov tib neeg nyob nruab nrab ntawm 50 txog 75 xyoo feem ntau yog cov neeg raug tus kab mob no. Hauv MND, qhov kev hnov lus tau raug cawm dim. Yog li ntawd, cov tsos mob xws li loog loog, tingling thiab mob tsis tshwm sim.
Pathogenesis
Sab saum toj thiab qis lub cev muaj zog neurons hauv qaum qaum, cranial paj hlwb lub cev muaj zog thiab cortices yog cov khoom tseem ceeb ntawm CNS cuam tshuam los ntawm MND. Tab sis, lwm cov kab mob neuronal kuj tuaj yeem cuam tshuam. Piv txwv li, hauv 5% ntawm cov neeg mob, Frontotemporal dementia tuaj yeem pom thaum nyob rau hauv 40% ntawm cov neeg mob qhov kev paub tsis meej pem hauv ntej. Qhov laj thawj ntawm MND tsis paub. Tab sis nws yog dav ntseeg tias protein aggregation nyob rau hauv lub axons yog lub hauv paus pathogenesis uas ua rau MND. Glutamate mediated excitotoxicity thiab oxidative neuronal puas kuj koom nrog hauv pathogenesis.
Tshuaj Kho Mob
Nyob hauv MND, pom plaub qhov kev kho mob tseem ceeb; cov no tuaj yeem ua ke nrog kev kis tus kabmob.
Amyotrophic Lateral Sclerosis (ALS)
ALS yog qhov kev nthuav qhia paraneoplastic uas feem ntau pib los ntawm ib ceg ceg thiab tom qab ntawd maj mam kis mus rau lwm cov ceg thiab pob tw. Kev nthuav qhia kho mob yuav yog focal leeg tsis muaj zog thiab nkim, nrog rau cov leeg fasciculation. Cramps muaj ntau. Ntawm kev kuaj xyuas, brisk reflexes, extensor plantar teb, thiab spasticity, uas yog cov cim qhia ntawm lub cev muaj zog neuron lesions tuaj yeem pom. Kev mob hnyav zuj zus ntawm cov tsos mob ntau lub hlis yuav lees paub qhov kev kuaj mob.
Daim duab 01: Amyotrophic Lateral Sclerosis
Progressive Muscular Atrophy
Qhov no ua rau tsis muaj zog, nqaij ntshiv, thiab fasciculation. Cov tsos mob no feem ntau pib ntawm ib ceg ceg thiab tom qab ntawd kis mus rau qhov chaw txha caj qaum. Qhov no yog qhov kev nthuav qhia lub cev muaj zog qis dua neuron.
Progressive Bulbar thiab Pseudobulbar Palsy
Qhia cov tsos mob yog dysarthria, dysphagia, qhov ntswg regurgitation kua thiab chocking. Cov no tshwm sim vim kev koom tes ntawm qis cranial paj nuclei thiab lawv cov kev sib txuas supranuclear. Nyob rau hauv ib tug sib xyaw bulbar palsy, fasciculation ntawm tus nplaig nrog qeeb, txhav tus nplaig txav tuaj yeem pom. Nyob rau hauv pseudobulbar palsy, lub siab lub ntsws incontinence nrog pathological luag thiab quaj tuaj yeem pom.
Primary Lateral Sclerosis
Primary lateral sclerosis yog ib hom kab mob tsis tshua muaj MND, uas ua rau maj mam nce tetraparesis thiab pseudobulbar palsy.
Diagnosis
Kev kuaj mob ntawm tus kab mob no feem ntau yog ua raws li kev soj ntsuam tsis txaus ntseeg. Kev tshawb nrhiav tuaj yeem ua tau txhawm rau txhawm rau tshem tawm lwm yam ua tau. EMG tuaj yeem ua tiav kom paub meej tias cov nqaij ntshiv vim qhov degeneration ntawm qis lub cev muaj zog neurons.
Kev Tshawb Fawb thiab Kev Tswj
Tsis muaj kev kho mob los txhim kho qhov tshwm sim. Riluzole tuaj yeem ua rau qeeb zuj zus ntawm tus kab mob, thiab nws tuaj yeem ua rau tus neeg mob lub neej expectancy nce mus txog 3-4 lub hlis. Kev noj zaub mov los ntawm kev noj zaub mov noj thiab lub tshuab ua pa tsis ua pa yuav pab tau kom muaj sia nyob ntev ntawm tus neeg mob txawm tias muaj sia nyob ntev dua 3 xyoos yog qhov txawv txav.
Ntau Sclerosis (MS) yog dab tsi?
Ntau Sclerosis yog ib qho mob autoimmune, T-cell mediated inflammatory kab mob cuam tshuam rau hauv nruab nrab paj hlwb. Ntau qhov chaw ntawm demyelination muaj nyob rau hauv lub hlwb thiab tus txha caj qaum. Qhov tshwm sim ntawm MS yog siab dua ntawm cov poj niam. MS feem ntau tshwm sim ntawm 20 thiab 40 xyoo. Qhov tshwm sim ntawm tus kab mob sib txawv raws li thaj chaw thaj chaw thiab haiv neeg keeb kwm yav dhau los. Cov neeg mob uas muaj MS yog raug rau lwm yam kab mob autoimmune. Ob qho tib si caj ces thiab ib puag ncig cuam tshuam rau lub pathogenesis ntawm tus kab mob. Peb qhov kev nthuav qhia ntau tshaj plaws ntawm MS yog optic neuropathy, hlwb qia demyelination, thiab txha caj qaum.
Pathogenesis
T cell mediated inflammatory txheej txheem tshwm sim feem ntau nyob rau hauv cov teeb meem dawb ntawm lub hlwb thiab tus txha caj qaum tsim cov plaques ntawm demyelination. 2-10 hli loj plaques feem ntau pom muaj nyob rau hauv cov hlab ntsha optic, periventricular cheeb tsam, corpus callosum, hlwb qia thiab nws cov cerebellar kev sib txuas thiab lub ncauj tsev menyuam qaum.
Nyob rau hauv MS, peripheral myelinated qab haus huv tsis cuam tshuam ncaj qha. Nyob rau hauv daim ntawv loj ntawm tus kab mob, kev puas tsuaj mus tas li axonal tshwm sim ua rau muaj kev tsis taus.
Hom Ntau Yam Sclerosis
- Raws-remitting MS
- Secondary progressive MS
- Primary progressive MS
- Relapsing-progressive MS
Cov cim qhia thiab cov tsos mob
- Mob qhov muag txav
- me me fogging ntawm lub hauv paus tsis pom kev / xim desaturation / ntom ntom nti
- Txo kev vibration sensation thiab proprioception hauv ko taw
- Clumsy tes or limb
- Kev tsis ruaj khov hauv kev taug kev
- tso zis ceev thiab zaus
- Neuropathic mob
- Nyob
- Spasticity
- Kev nyuaj siab
- Kev sib deev tsis zoo
- Kub rhiab
Nyob rau hauv MS lig, cov tsos mob hnyav heev nrog optic atrophy, nystagmus, spastic tetraparesis, ataxia, paj hlwb cov tsos mob, pseudobulbar palsy, urinary incontinence thiab kev paub tsis meej tuaj yeem pom.
Daim duab 2: Cov tsos mob thiab cov tsos mob ntawm ntau yam Sclerosis
Diagnosis
Kev kuaj mob MS tuaj yeem ua tau yog tias tus neeg mob tau muaj 2 lossis ntau qhov kev tawm tsam cuam tshuam rau ntau qhov chaw ntawm CNS. Kev soj ntsuam zoo li MRI, CT thiab CSF tuaj yeem ua tiav txhawm rau muab pov thawj txhawb kev kuaj mob.
Kev Tswj Xyuas thiab Kev Ntsuas
Tsis muaj kev kho mob rau MS. Tab sis ntau yam tshuaj immunomodulatory tau qhia los hloov kho cov txheej txheem ntawm inflammatory relapsing-remitting theem ntawm MS. Cov no yog hu ua Disease Modifying Drugs (DMDs). beta-interferon thiab glatiramer acetate yog cov piv txwv ntawm cov tshuaj no.
Dab tsi yog qhov zoo sib xws ntawm Ntau Yam Sclerosis thiab Tsav Neuron Kab Mob
- Ntau yam sclerosis thiab lub cev muaj zog neuron kab mob cuam tshuam rau lub paj hlwb
- Yuav tsis muaj qhov kho tau meej rau ob qho kev mob no.
Dab tsi yog qhov txawv ntawm Ntau Yam Sclerosis thiab Motor Neuron Kab Mob?
Multiple Sclerosis vs Motor Neuron Disease |
|
| Multiple Sclerosis yog ib qho mob autoimmune, T-cell mediated inflammatory kab mob cuam tshuam rau Central Nervous System. | MND yog ib qho mob hnyav uas ua rau muaj kev qaug zog zuj zus thiab thaum kawg tuag vim kev ua pa tsis ua haujlwm lossis kev ua pa. |
| Yam kab mob | |
| Mulitple sclerosis yog ib qho mob neuroinflammatory. | MND is a neurodegenerative disorder |
| Hnub nyoog Group | |
| Ntau tus kab mob sclerosis cuam tshuam rau cov neeg hluas uas muaj hnub nyoog 20 txog 40 xyoo. | MND cov neeg mob feem ntau muaj hnub nyoog 50 txog 70 xyoo. |
| Sex | |
| Qhov tshwm sim ntawm ntau yam sclerosis yog siab dua ntawm cov poj niam. | MND tshwm sim feem ntau ntawm cov txiv neej. |
| Pathogenesis | |
| Ntau tus sclerosis yog tshwm sim los ntawm demyelination ntawm cov neurons. | Kev sib sau ntawm cov proteins hauv cov axons yog cov hauv paus pathogenesis ntawm MND. |
Summary – Ntau Sclerosis vs Tsav Neuron Kab Mob
MND yog kab mob neurodegenerative uas cov tsos mob hnyav zuj zus tuaj. Txawm hais tias ntau tus kab mob sclerosis, uas yog ib qho kev mob neuroinflammatory, kev loj hlob ntawm tus nqi qeeb, nws tuaj yeem ua rau muaj kev puas tsuaj loj heev. Qhov no yog qhov sib txawv tseem ceeb ntawm ntau yam sclerosis thiab kab mob neuron motor.
Download PDF Version of Multiple Sclerosis vs Motor Neuron Disease
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Ntau Yam Sclerosis thiab Motor Neuron Kab Mob.
