Qhov Tseem Ceeb Qhov txawv - Freund's Complete vs Incomplete Adjuvant
Immunology yog ib qho kev kawm loj heev. Nws feem ntau cuam tshuam nrog cov tshuaj tiv thaiv antigen-antibody. Cov tshuaj tiv thaiv kab mob no yog siv los txheeb xyuas tus kab mob lossis muaj lub cev txawv teb chaws xws li cov kab mob sib kis. Antigens yog cov cim ntawm cov kab mob uas feem ntau yog cov proteins. Qee cov kab mob yuav muaj cov carbohydrate lossis lipid-based antigenic cov cim. Cov tshuaj tiv thaiv yog B cell immunoglobulins tsim los ntawm tus tswv teb rau cov tshuaj tiv thaiv.
Adjuvants yog cov khoom siv hluavtaws uas raug xa mus rau cov tshuaj tiv thaiv kab mob uas muaj peev xwm txhim kho lub cev tiv thaiv kab mob tiv thaiv antigen lossis pab pawg antigens. Yog li, daim ntawv thov tseem ceeb ntawm adjuvants yog nyob rau hauv kev tsim tshuaj tiv thaiv, qhov twg ib qho adjuvant tau qhia los txhim kho lub cev tiv thaiv kab mob ntawm tus tswv tsev. Nws kuj tseem siv rau hauv kev tsim cov khoom siv hluavtaws. Muaj ntau hom adjuvants, tawm ntawm Freud's Complete thiab Freund's Incomplete Adjuvant yog ib qho ntawm thawj tsim. Freund's Complete Adjuvant yog tsim los ntawm ib qho emulsion ntawm dej thiab ntxhia roj uas muaj cov kab mob Mycobacteria tua, nyob rau hauv sib piv, Freund's Incomplete Adjuvant yog tsim los ntawm emulsion ntawm dej thiab ntxhia roj yam tsis muaj Mycobacteria ntxiv. Kev tsis tuaj thiab muaj cov tshuaj tiv thaiv Mycobacterial yog qhov sib txawv tseem ceeb ntawm Freud qhov ua tiav thiab tsis tiav adjuvants.
Freund's Complete Adjuvant yog dab tsi?
Hauv xyoo 1936, Jules T Freund tau tshawb pom thawj tus kws kho mob hu ua Freund's Complete Adjuvant. Freund's Complete Adjuvant muaj cov cua sov tua kab mob Mycobacterium tuberculosis nyob rau hauv ib qho emulsion ntawm dej thiab cov roj uas tsis yog metabolizable. Cov roj uas tsis yog metabolizable no yog cov roj paraffin thiab mannide monooleate. Cov cua sov tua cov kab mob Mycobacteria uas muaj qee cov cuab yeej antigenic, tsis muaj lub luag haujlwm ua rau tus kab mob. Yog li ntawd, nws tau koom nrog hauv kev nyiam cov macrophages thiab lwm cov hlwb mus rau qhov chaw txhaj tshuaj. Qhov kev ua ntawm kub-tua Mycobacteria yuav txhim khu kev tiv thaiv kab mob. Yog li Freund's Complete Adjuvant feem ntau yog siv rau kev txhaj tshuaj thawj zaug ntawm kev txhaj tshuaj. Nws kuj tau hais tias Freund's Complete Adjuvant kuj pab hauv T cell ua kom tsis yog B cell ua kom muaj kev tiv thaiv.
Ib qho tseem ceeb ntawm Freund's Complete Adjuvant-mediated teb yog ib qho kev mob hnyav ntawm qhov chaw ntawm antigen deposition. Freund's Complete Adjuvant mixs yog siv nyob rau hauv thawj qhov kev txhaj tshuaj tiv thaiv kab mob vim tias muaj qhov tsis zoo ntawm kev siv cov tshuaj tiv thaiv tag nrho, vim nws tuaj yeem txhim kho cov kab mob pathogenic hauv cov neeg tiv thaiv kab mob vim muaj kev cuam tshuam ntev ntawm cov tshuaj tiv thaiv.
Freund's Incomplete Adjuvant yog dab tsi?
Freund's Incomplete Adjuvants kuj muaj cov emulsion ntawm cov dej thiab cov roj uas tsis yog metabolizable thiab tsis muaj cov kab mob Mycobacterium tua hluav taws kub. Freund's Incomplete Adjuvants yog siv los tsim cov dej-hauv-roj emulsions ntawm antigens. Freund's Incomplete Adjuvants induce ib tug feem ntau T pab hom 2 (Th2) biased teb los ntawm kev tsim ib tug depot ntawm qhov chaw txhaj tshuaj nrog stimulation ntawm antibody-tsim plasma hlwb. Qhov no tso cai rau qeeb tso tawm ntawm cov antigen thiab txhawb cov T hlwb kom zais los ntawm cov plasma hlwb. Freund's Incomplete Adjuvants txhawb nqa Th2 hlwb. Freund's Incomplete Adjuvants tsis muaj tshuaj lom vim nws tsis muaj ib hom kab mob, yog li, nws yog siv nyob rau theem latent ntawm kev txhaj tshuaj tiv thaiv kab mob. Qhov tsis zoo ntawm kev siv Freund's Incomplete Adjuvants yog qhov nyuaj hauv kev sib xyaw nrog cov antigen hauv kev sib piv nrog Freund's Complete Adjuvants.
Dab tsi yog qhov zoo sib xws ntawm Freund's Complete and Incomplete Adjuvant?
• Ob leeg muaj emulsion ntawm dej thiab ntxhia roj.
• Ob leeg koom nrog txhawm rau txhim kho lub cev tiv thaiv kab mob tiv thaiv kab mob antigen.
• Ob leeg txhawb kev tsim cov T hlwb, feem ntau T pab hlwb.
• Ob leeg siv los tsim cov tshuaj tiv thaiv kab mob.
Qhov txawv ntawm Freund's Complete and Incomplete Adjuvant yog dab tsi?
Freund's Complete Adjuvant vs Freund's Incomplete Adjuvant |
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| Freund's Complete Adjuvant yog tsim los ntawm emulsion ntawm dej thiab ntxhia roj uas muaj cov kab mob tua hluav taws kub tua Mycobacteria. | Freund's Incomplete Adjuvant yog tsim los ntawm emulsion ntawm dej thiab ntxhia roj yam tsis muaj Mycobacteria ntxiv. |
| feeb | |
| Freund's Complete Adjuvant stimulates zus tau tej cov Th1 hlwb. | Freund's Incomplete Adjuvant stimulates zus tau tej cov Th2 hlwb. |
| sijhawm tswj hwm | |
| Freund's Complete Adjuvant yog tswj hwm nyob rau theem pib ntawm kev txhaj tshuaj tiv thaiv kom tau txais cov teebmeem tam sim. | Freund's Incomplete Adjuvant yog tswj hwm nyob rau theem tom ntej ntawm kev txhaj tshuaj tiv thaiv kab mob, feem ntau yog siv rau kev txhawb nqa tom qab pib txhaj tshuaj nrog Freund's Complete Adjuvant. |
| Heat-tua mycobacterium species | |
| Tam sim no hauv Freund's Complete Adjuvant | Asent in Freund's Incomplete Adjuvant. |
| Response | |
| Teb yog nrawm hauv Freund's Complete Adjuvant. | Teb qeeb hauv Freund's Incomplete Adjuvant. |
| Disadvantage | |
| Freund's Complete Adjuvant tuaj yeem ua rau muaj tus kab mob loj hlob hauv cov neeg muaj kev tiv thaiv kab mob vim raug mob mus ntev. | Kev nyuaj hauv kev tsim nrog antigen thaum npaj tshuaj tiv thaiv yog qhov tsis zoo ntawm Freund's Incomplete Adjuvant. |
Summary – Freund's Complete vs Incomplete Adjuvant
Adjuvants yog cov khoom txhawb nqa uas siv los txhawb lub cev tiv thaiv kab mob ntawm tus tswv tsev. Freud's adjuvants yog thawj zaug qhia uas muaj roj-dej emulsions. Qhov ua tiav thiab tsis tiav adjuvants txawv nyob rau hauv lub xub ntiag thiab tsis muaj cua sov tua Mycobacterium hom raws li. Freund's Complete Adjuvant muaj cov kab mob mycobacterial tua thaum Freund's Incomplete Adjuvant tsis muaj cov kab mob mycobacterial. Ntau qhov kev tshawb fawb tau ua nrog cov adjuvants sib txawv txhawm rau txheeb xyuas lub cev tiv thaiv kab mob. Cov kev tshawb fawb no tsom rau kev tsim cov tshuaj tiv thaiv zoo dua los tiv thaiv kab mob sib kis.
Download the PDF Version of Freund's Complete vs Incomplete Adjuvant
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv ntawm Freund's Complete and Incomplete Adjuvant
