Key Difference – B Cell vs T Cell Lymphoma
Malignancies ntawm lymphoid system hu ua lymphomas. Lawv tuaj yeem tshwm sim ntawm txhua qhov chaw uas pom cov ntaub so ntswg lymphoid. Qhov xwm txheej ntawm ntau hom kab mob sib kis tau nce ntau xyoo. Qhov kev nthuav qhia ntau tshaj plaws ntawm lymphomas yog peripheral lymphadenopathy lossis cov tsos mob vim yog cov qog ntshav qog ntshav. Raws li WHO kev faib tawm, muaj 2 hom lymphomas li Hodgkin's thiab non-Hodgkin's lymphomas. Non-Hodgkin's lymphoma yog lub kaus mom uas npog ntau qhov sib cais ntawm B-thiab T-cell malignancies. Kwv yees li 80% ntawm NHL yog B-cell keeb kwm thiab 20% ntxiv yog T-cell keeb kwm. Qhov no tuaj yeem suav tias yog qhov sib txawv tseem ceeb ntawm B cell thiab T cell lymphoma. Kev faib tawm ntawm NHL yog ua tiav raws li lub hauv paus chiv keeb (T cell lossis B cell) thiab theem ntawm lymphocyte maturation ntawm qhov malignancy tshwm sim (precursor thiab mature).
B Cell Lymphoma yog dab tsi?
Lymphoid system malignancies uas yog B lymphocyte keeb kwm hu ua B-cell lymphomas. Kwv yees li 80% ntawm tag nrho NHL yog B cell keeb kwm. Tus thawj subtypes ntawm B cell lymphomas yog Follicular lymphomas, Diffuse loj B cell lymphomas, Burkitt's lymphoma, Mantle cell lymphoma, thiab lymphoplasmacytic lymphoma
Follicular Lymphoma
Follicular lymphoma yog qhov thib ob uas muaj NHL thoob ntiaj teb. Cov no tsis tshua pom muaj nyob rau hauv cov menyuam yaus thiab feem ntau tshwm sim hauv cov hnub nyoog nruab nrab lossis cov neeg laus. Feem ntau ntawm cov neeg mob muaj mob lymphadenopathy ntawm ntau qhov chaw. Qee tus neeg mob tuaj yeem muaj cov tsos mob B. Nyob rau hauv tej yam subtypes, pob txha pob txha infiltration yog muaj. Txawm hais tias qhov feem pua ntawm cov neeg mob uas tau kho tag nrho ntawm tus mob no me me, qhov kev kho tshiab tshiab (rituximab), uas yog lub hom phiaj ntawm CD20 antigen qhia ntawm yuav luag tag nrho B-cell lymphomas, zoo li muaj txiaj ntsig zoo hauv kev tawm tsam tus kab mob.
Nyob rau hauv txog li 25% ntawm cov neeg mob, kev hloov pauv mus rau qhov loj B-cell lymphoma tuaj yeem tshwm sim.
Kev tswj hwm
Theem 1 - megavoltage irradiation
Theem 2 - Chemo immunotherapy incorporating Rituximab, CHOP-R (cyclophosphamide, doxorubicin, vincristine, thiab prednisolone ntxiv rau rituximab) thiab R-CVP (rituximab ntxiv rau cyclophosphamide, vincristine, thiab prednisolone)
Diffuse Loj B-cell Lymphoma
Nws yog qhov thib ob uas muaj qog ntshav qog ntshav hauv menyuam yaus thiab cov neeg laus qog ntshav ntau tshaj plaws thoob ntiaj teb. Muaj kev sib tshooj ntawm classical diffuse loj B-cell lymphoma thiab Burkitt's lymphoma. Qhov tshwm sim ntawm cov txiv neej yog siab dua cov poj niam.
Daim duab 01: Diffuse Loj B Cell Lymphoma
Tshuaj Kho Mob
- Painless lymphadenopathy
- mob plab
- 'B'symptoms
Kev tswj hwm
Nyob rau hauv tus neeg mob yau uas tsis muaj kev pheej hmoo, muaj peev xwm kho tau tiav. Kev kho mob yuav tsum pib sai sai tom qab kuaj pom.
Tus kab mob tsis tshua muaj kev pheej hmoo - 'CHOP-R' ua raws los ntawm kev koom tes ua haujlwm irradiation
Kev pheej hmoo nruab nrab thiab tsis zoo - Chemoimmunotherapy, 'CHOP-R'
Burkitt's Lymphoma
Cov qog ntshav qog ntshav sai tshaj plaws yog Burkitt's lymphoma, uas muaj lub sijhawm ua ob zaug sai heev. Nws yog qhov mob hnyav tshaj plaws thaum yau thoob ntiaj teb. Qhov tshwm sim ntawm cov poj niam yog siab dua li ntawm cov txiv neej. Muaj 3 yam tseem ceeb ntawm Burkitt's lymphomas li Endemic (ib txwm Epstein-Barr tus kab mob-koom nrog), Sporadic, AIDS- ntsig txog. Nyob rau hauv lub ntiaj teb sab hnub poob, dhau 10 xyoo dhau los, qhov kev tshwm sim ntawm Burkitt's lymphoma tau zoo tuaj.
Tshuaj Kho Mob
- lub puab tsaig hlav
- plab plab
Kev tswj hwm
Tom qab kev tshawb fawb tsim nyog, tus neeg mob yuav tsum tau ua kom hemodynamically thiab metabolically ruaj khov ua ntej yuav kho. Kev ntsuas yuav tsum tau ua kom txo qis cov qog lysis syndrome. Tom qab kev kho mob pib, kev saib xyuas ntawm electrolytes yuav tsum tau ua ntau zaus. Kev kho tus qauv muaj xws li kev sib xyaw ua ke ntawm kev siv tshuaj khomob.
YT Cell Lymphoma yog dab tsi?
Lymphomas uas muaj T lymphocyte keeb kwm hu ua T-cell lymphomas. Lawv suav txog 20% ntawm tag nrho NHL. T-cell lymphomas feem ntau tshwm sim nyob rau sab hnub tuaj. Qhov kev nthuav qhia ntau tshaj plaws ntawm tus kab mob yog nodal thiab cutaneous, tab sis nyob rau hauv ib co ntawm cov subtypes tshwj xeeb, muaj peev xwm muaj daim siab thiab cutaneous cov ntaub so ntswg. Peripheral T-cell lymphomas nrog qhov kev nthuav qhia nodal muaj qhov tsis zoo.
Peripheral T-cell lymphoma thiab angioimmunoblastic T-cell lymphoma yog cov subtypes ntawm T cell lymphomas. Thawj qhov kev nthuav qhia ntawm ob hom yog lymphadenopathy. Cov tsos mob 'B' yog tshwm sim hauv T-cell lymphomas, tsis zoo li hauv B cell lymphomas. Hauv angioimmunoblastic T-cell lymphomas, cov yam ntxwv ntawm tus kab mob inflammatory, nrog kub taub hau, pob liab liab thiab electrolyte txawv txav tuaj yeem pom. Cov tsos mob no txhim kho sai sai nrog kev tswj hwm ntawm corticosteroids lossis cov tshuaj alkylating tsawg.
Daim duab 02: Cutaneous T Cell Lymphoma
Kev tswj hwm
Tom qab kev soj ntsuam tus qauv, cov neeg mob tau kho nrog kev sib xyaw ua ke ntawm cov tshuaj tua kab mob. Raws li T-hlwb tsis qhia CD20, Rituximab tsis siv los kho T-cell lymphomas. Tsis muaj tshuaj sib npaug rau T-cell lymphomas. Nrog rau kev kho mob, kev daws teeb meem ntawm tus kab mob yuav tshwm sim tab sis kev rov tshwm sim feem ntau tshwm sim ntawm lub voj voog. Txoj kev kho thib ob tsis txaus siab txawm hais tias kev kho mob myeloablative tuaj yeem tau txais txiaj ntsig tsawg ntawm cov neeg mob.
Dab tsi zoo sib xws ntawm B Cell thiab T Cell Lymphoma?
Ob hom lymphomas tshwm sim los ntawm cov ntaub so ntswg lymphoid
Qhov txawv ntawm B Cell thiab T Cell Lymphoma yog dab tsi?
B Cell vs T Cell Lymphoma |
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| Lymphoid system malignancies uas yog B lymphocyte keeb kwm yog hu ua B-cell lymphomas. | Lymphomas uas muaj T lymphocyte keeb kwm yog hu ua T-cell lymphomas. |
| Kev ntsuas tau zoo. | In piv rau B cell lymphomas, T cell lymphomas muaj qhov tsis zoo. |
| Rituximab siv rau hauv kev kho mob. | Rituximab siv tsis tau rau hauv kev kho mob. |
Summary – B Cell vs T Cell Lymphoma
Qhov txawv ntawm B cell thiab T cell lymphoma nyob rau hauv lawv lub hauv paus chiv keeb; lymphoid malignancies uas yog B lymphocyte keeb kwm hu ua B-cell lymphomas thaum lymphomas uas muaj T lymphocyte keeb kwm hu ua T-cell lymphomas. Kev kuaj mob ntawm cov malignancies nyob rau hauv lawv cov theem ua ntej drastic txhim kho tus kab mob prognosis. Yog li ntawd, yuav tsum tau muab tswv yim kho mob yog tias ib tug neeg muaj ib qho ntawm cov cim ceeb toom uas tau tham hauv kab lus no.
Download PDF Version of B Cell vs T Cell Lymphoma
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm B Cell thiab T Cell Lymphoma.
