Qhov sib txawv tseem ceeb ntawm fibroblast thiab myofibroblast yog qhov fibroblast pom nyob rau hauv cov hlwb mesenchymal uas ib txwm muaj nyob rau hauv stroma ntawm ntau cov ntaub so ntswg, thaum myofibroblast yog ib qho sib txawv fibroblast nrog kev ua haujlwm contractile.
Fibroblast thiab myofibroblast ua lub luag haujlwm tseem ceeb hauv daim tawv nqaij homeostasis thiab kho cov ntaub so ntswg physiological. Lawv feem ntau yog embedded nyob rau hauv lub extracellular matrix lawv secrete. Lub microenvironment ntawm cov hlwb no tsim ib lub network ntawm cov ntaub so ntswg thaum kho cov ntaub so ntswg, uas ua rau cov ntaub so ntswg sib txawv, proliferation, los yog apoptosis. Fibroblasts muaj peev xwm hloov kho cov khoom siv ntawm cov khoom siv hluav taws xob ntxiv hauv cov ntaub so ntswg thiab hloov mus rau myofibroblasts. Myofibroblasts yog tshwj xeeb fibroblasts nrog kev ua haujlwm contractile.
YFibroblast yog dab tsi?
Fibroblast yog ib lub cell lom uas tsim cov extracellular matrix thiab collagen thiab yog tam sim no feem ntau nyob rau hauv cov ntaub so ntswg sib txuas uas tsim cov qauv txheej txheem rau tsiaj cov ntaub so ntswg. Nyob rau hauv cov ntaub so ntswg sib txuas ntawm cov tsiaj, fibroblasts yog hom cell feem ntau tam sim no. Cov hlwb no muaj cov ceg cytoplasm. Lub cytoplasm nyob ib puag ncig ib qho elliptical speckled nucleus nrog ob lossis ntau lub nuclei.
Daim duab 01: Fibroblasts
Txhua tus fibroblasts tuaj yeem txheeb xyuas los ntawm cov yam ntxwv uas muaj ntau qhov ntxhib endoplasmic reticulum. Fibroblasts tsis tsim cov monolayers tiaj tus, tsis zoo li cov hlwb epithelial uas kab cov qauv hauv lub cev. Lawv kuj tsis txwv los ntawm kev sib txuas nrog polarizing rau basal lamina ntawm ib sab. Fibroblasts tuaj yeem pab txhawb rau basal lamina Cheebtsam hauv qee qhov xwm txheej. Kev ua haujlwm ntawm fibroblasts yog tsim cov collagen fibers, glycosaminoglycans, reticular thiab elastic fibers. Lawv kuj ua lub luag haujlwm tseem ceeb hauv kev kho qhov txhab los ntawm kev cog lus ntawm cov npoo ntawm qhov txhab. Sib nrug los ntawm ob txoj haujlwm ua haujlwm, fibroblasts ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob rau cov ntaub so ntswg raug mob thiab tseem koom nrog hauv kev pib mob ntawm cov kab mob pathogenic.
Myofibroblast yog dab tsi?
Myofibroblast yog ib qho kev cog lus fusiform ntawm tes nrog lub xub ntiag ntawm α-cov leeg nqaij du actin hauv nws cov cytoplasmic stress fibers. Myofibroblasts tsim thaum lub sij hawm sib txawv ntawm cov txheej txheem fibroblasts. Fibroblasts tuaj yeem hloov mus rau hauv myofibroblasts siv cov duab kho. Myofibroblasts qhia txog qib siab ntawm cytokines, extracellular matrix, thiab α-smooth leeg actin. Lawv ua lub luag haujlwm tseem ceeb hauv kev mob, kev sib txuas cov ntaub so ntswg, thiab lub ntsws cov ntaub so ntswg.
Daim duab 02: Myofibroblasts
Ntxiv mus, myofibroblasts tau txheeb xyuas hauv cov ntaub so ntswg granulation thaum kho daim tawv nqaij. Myofibroblasts feem ntau pom muaj nyob rau hauv cov ntaub so ntswg granulation, caws pliav (fibrosis), thiab stroma ntawm cov qog. Lawv kuj muaj nyob rau hauv lub plab hnyuv thiab genitourinary ib ntsuj av. Nyob rau hauv cov chaw no, myofibroblasts yog tam sim no sub-epithelially nyob rau hauv lub mucosa nto.
Dab tsi zoo sib xws ntawm Fibroblast thiab Myofibroblast?
- Fibroblast thiab myofibroblast yog ob hom kab mob lom.
- Lawv muaj keeb kwm.
- Ob leeg fibroblasts thiab myofibroblasts ua lub luag haujlwm tseem ceeb hauv kev kho qhov txhab.
- Ntxiv mus, ob lub hlwb ua kom lub qhov txhab zoo los ntawm kev cog lus ntawm cov npoo ntawm qhov txhab zoo.
Qhov txawv ntawm Fibroblast thiab Myofibroblast yog dab tsi?
Fibroblast muaj nyob rau hauv cov hlwb mesenchymal uas ib txwm muaj nyob hauv stroma ntawm ntau cov ntaub so ntswg, thaum myofibroblast yog ib qho sib txawv fibroblast. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm fibroblast thiab myofibroblast. Tsis tas li ntawd, fibroblast yog ib qho loj, tiaj tus, thiab elongated cell uas nthuav tawm ntawm qhov kawg ntawm lub cev ntawm tes. Txawm li cas los xij, myofibroblasts yog cov hlwb loj nrog ruffled daim nyias nyias nrog lub siab ua haujlwm endoplasmic reticulum. Ntxiv mus, fibroblasts tsis muaj actin du nqaij, thaum myofibroblasts muaj actin du nqaij.
Cov hauv qab no qhia txog qhov sib txawv ntawm fibroblast thiab myofibroblast hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – Fibroblast vs Myofibroblast
Fibroblast thiab myofibroblast ua lub luag haujlwm tseem ceeb hauv kev kho lub cev nqaij daim tawv lossis kho qhov txhab. Fibroblast muaj nyob rau hauv mesenchymal hlwb uas ib txwm muaj nyob rau hauv stroma ntawm ntau cov ntaub so ntswg. Txawm li cas los xij, myofibroblast yog qhov sib txawv ntawm fibroblast. Ntxiv mus, kev ua haujlwm ntawm fibroblasts yog tsim collagen fibers, glycosaminoglycans, reticular thiab elastic fibers. Lub caij no, myofibroblasts ua lub luag haujlwm tseem ceeb hauv kev mob, kev sib txuas cov ntaub so ntswg, thiab lub ntsws cov ntaub so ntswg. Tsis tas li ntawd, myofibroblasts tsim los ntawm kev sib txawv ntawm fibroblasts. Yog li, qhov no qhia txog qhov sib txawv ntawm fibroblast thiab myofibroblast.
