Qhov sib txawv tseem ceeb ntawm v-SNARE thiab t-SNARE yog tias v-SNARE cuam tshuam nrog daim nyias nyias ntawm lub cev thauj khoom thaum lub sijhawm budding thaum t-SNARE cuam tshuam nrog cov paj hlwb.
SNARE (ib qho lus piav qhia los ntawm cov kua dej N-ethylmaleimide rhiab fusion protein (NSF) txuas receptor) yog tsev neeg muaj protein ntau uas muaj 24 ntau hom Saccharomyces cerevisiae thiab 60 ntau hom ntawm cov tsiaj txhu. Lub luag haujlwm tseem ceeb ntawm SNARE cov proteins yog los kho cov fusion ntawm lub vesicle nrog lub hom phiaj membranes. Hauv lwm lo lus, SNARE proteins mediate exocytosis. Lawv kuj kho cov fusion ntawm daim nyias nyias-txheej compartments xws li lysosomes. SNAREs tuaj yeem muab faib ua ob pawg loj: v (vesicle) - SNARE thiab t (lub hom phiaj) - SNARE.
v-SNARE yog dab tsi?
v-SNARE yog ib hom SNARE protein cuam tshuam nrog daim nyias nyias ntawm kev thauj vesicle thaum tus txheej txheem ntawm budding, uas mediates exocytosis. VAMP7 thiab VAMP 8 yog ob qho piv txwv tseem ceeb ntawm v-SNARE proteins. Lawv muaj ntau tshaj li 70% ntawm ceg amino acids nyob rau hauv lub transmembrane domain cheeb tsam.
Daim duab 01: SNARE Vesicles
V-SNARE pab exocytosis ntawm cov zymogen loj granules thiab mast cell vesicles, ua kom yooj yim pore expansion thiab tso tawm ntawm loj molecules xws li interferon. R-SNAREs yog cov tswv cuab zoo ib yam li v-SNARE, uas kho cov vesicle fusion zoo ib yam li v-SNARE.
T-SNARE yog dab tsi?
t-SNARE yog ib hom SNARE protein cuam tshuam nrog cov hlab ntsha hauv cov hlab ntsha thiab tsim cov subcomplexes ruaj khov thiab ua haujlwm raws li kev qhia rau v-SNARE. Syntaxin 1 thiab SNAP-25 yog cov tswv cuab ntawm cov tsev neeg muaj protein ntau xws li t-SNARE.
Daim duab 02: Hom SNAREs
Lawv qhov chaw tshwj xeeb rau subcellular membranes txhais qhov chaw thauj vesicles khi thiab fuse. Q-SNARE yog cov tswv cuab zoo ib yam li t-SNARE uas kho vesicle fusion zoo ib yam li t-SNARE.
Qhov Zoo sib xws ntawm v-SNARE thiab t-SNARE yog dab tsi?
- v-SNARE thiab t-SNARE yog subtypes ntawm SNARE proteins.
- Lawv pab kho kom haum xeeb ntawm fusion ntawm cov hlab ntsha nrog lub hom phiaj membranes.
- Ob leeg ua lub luag haujlwm tseem ceeb hauv cov txheej txheem ntawm exocytosis.
Qhov txawv ntawm v-SNARE thiab t-SNARE yog dab tsi?
Qhov sib txawv tseem ceeb ntawm v-SNARE thiab t-SNARE yog tias v-SNARE feem ntau yog muab tso rau hauv daim nyias nyias ntawm lub vesicle thauj thaum lub sij hawm txheej txheem ntawm budding, thaum t-SNARE yog txuam nrog paj hlwb terminal membranes. Lwm cov ntsiab lus rau v-SNARE thiab t-SNARE yog vesicle SNARE thiab phiaj-SNARE, feem. Lwm qhov sib txawv ntawm v-SNARE thiab t-SNARE yog lawv txoj haujlwm. Lub luag haujlwm ntawm v-SNARE yog los kho cov txheej txheem ntawm exocytosis, thaum lub luag haujlwm ntawm t-SNARE yog tsim cov subcomplexes ruaj khov thiab ua haujlwm raws li kev qhia rau v-SNARE. Ntxiv mus, VAMP7 thiab VAMP 8 yog ob lub ntsiab ntawm v-SNARE thaum Syntaxin 1 thiab SNAP-25 yog ob hom tseem ceeb ntawm t-SNARE.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm v-SNARE thiab t-SNARE hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – v-SNARE vs t-SNARE
SNARE yog tsev neeg muaj protein ntau.v-SNARE yog ib hom SNARE protein cuam tshuam nrog daim nyias nyias ntawm kev thauj vesicle thaum lub sij hawm budding, uas kho cov exocytosis. t-SNARE yog ib hom SNARE protein cuam tshuam nrog cov hlab ntsha hauv cov hlab ntsha. Ntxiv mus, lub luag haujlwm tseem ceeb ntawm SNARE cov proteins yog los kho cov fusion ntawm cov hlab ntsha nrog lub hom phiaj daim nyias nyias. Hauv lwm lo lus, SNARE proteins mediate exocytosis. t-SNAREs, ntawm qhov tod tes, tsim cov subcomplexes ruaj khov thiab ua haujlwm raws li kev qhia rau v-SNARE. Yog li, qhov no qhia txog qhov sib txawv ntawm v-SNARE thiab t-SNARE.
