Qhov txawv ntawm NFkb1 thiab NFkb2 yog tias cov noob NFkb1 codes cov protein NFkb1 hauv tib neeg thaum lub noob NFkb2 codes cov protein NFkb2 hauv tib neeg.
NFkb yog cov protein ntau uas tswj cov kev hloov pauv ntawm DNA, cytokine ntau lawm, thiab cell ciaj sia. Nws feem ntau yog koom nrog hauv cov lus teb ntawm tes rau stimuli xws li kev ntxhov siab, cytokines, dawb radicals, hnyav hlau, ultraviolet irradiation, oxidized LDL, kab mob los yog kab mob antigens. Nws kuj tseem ua lub luag haujlwm tseem ceeb hauv kev tswj lub cev tiv thaiv kab mob kom raug tiv thaiv kab mob. Dysregulation ntawm NFkb tau txuas rau mob qog noj ntshav, kab mob inflammatory, septic shock, kab mob kis, thiab kev txhim kho lub cev tsis zoo. Muaj tsib cov proteins hauv tsev neeg NFkb protein: NFkb1, NFkb2, ReIA, ReIB, thiab c-ReI.
NFkb1 yog dab tsi?
NFkb1 yog cov protein nyob hauv tib neeg uas yog encoded los ntawm NFkb1 noob. NFkb1 noob ib txwm encodes cov protein ntawm 105 kDa (P105) loj. Cov protein no tuaj yeem dhau los ua kev sib txuas lus los ntawm 26S proteasome los tsim 50 kDa protein (P50). Lub 105 kDa protein yog Rel protein-specific transcription inhibitor, thaum lub 50 kDa protein yog DNA binding subunit ntawm NFkb protein complex. Ntxiv mus, P50-RelA dimer yog ib qho kev hloov pauv hloov pauv.
Figure 01: NFkb1
NFkb yog ib qho kev hloov pauv uas tau qhib los ntawm ntau yam stimuli xws li cytokines, dawb radicals, hluav taws xob ultraviolet, kab mob lossis kab mob. Lub tshuab txais NFkb qhov kev hloov pauv tau tuaj yeem hloov mus rau hauv lub nucleus thiab txhawb nqa kev qhia ntawm cov noob uas koom nrog ntau yam kev ua haujlwm lom neeg. Raws li cov xwm txheej tshwj xeeb, ntau dua 200 cov noob tuaj yeem raug tsom los ntawm NFkb hauv ntau hom cell. Qhov kev ua kom tsis tsim nyog ntawm NFkb tau cuam tshuam nrog cov kab mob inflammatory. Ntawm qhov tod tes, qhov inhibition ntawm NFkb ua rau tsis tsim nyog lub cev tiv thaiv kab mob los yog ncua kev loj hlob ntawm tes. Tsis tas li ntawd, NFkb1 protein tau pom tias muaj kev cuam tshuam nrog ntau cov proteins tseem ceeb xws li BCL3, C22orf25, HDAC1, IKK2, ITGB3BP, MEN1, RELA, RELB, STAT3, STAT6, thiab lwm yam.
NFkb2 yog dab tsi?
NFkb2 yog cov protein nyob hauv tib neeg uas yog encoded los ntawm NFkb2 noob. Cov noob no encodes cov protein ntau ntev uas yog 100 kDa (P100) loj. Cov protein no yog cotranslationally ua tiav rau hauv cov protein ntau uas yog 52 kDa (P52) loj. Cov proteins encoded los ntawm NFkb2 noob tuaj yeem ua haujlwm raws li ob qho tib si transcriptional activator thiab repressor nyob ntawm nws tus khub dimerization.
Daim duab 02: NFkb2
P52-RELB dimer yog qhov hloov pauv hloov pauv, thaum P100 yog tus hloov pauv hloov pauv. Tsis tas li ntawd, cov chromosomal rearrangements thiab translocation ntawm qhov chaw no tau pom nyob rau hauv ib co B cell lymphomas. Qhov no yog vim lub fusion protein tsim tom qab translocation. Ntxiv mus, muaj ib tug pseudogene rau no NFkb2 noob ntawm chromosome 18. Lub mutated version ntawm NFkb2 protein ua rau adrenocorticotropic hormone deficiency thiab DAVID syndrome. DAVID Syndrome yog pituitary hormone deficiency thiab CVID (kev tiv thaiv kab mob tsis sib xws).
Qhov Zoo sib xws ntawm NFkb1 thiab NFkb2 yog dab tsi?
- NFkb1 thiab NFkb2 yog ob qho proteins hauv NFkb protein tsev neeg.
- Ob leeg cov proteins muaj nyob rau hauv chav kawm 1 NFkb protein complex.
- Ob leeg cov proteins tuaj yeem coj tus cwj pwm ua tus hloov pauv thiab ua rau muaj kev tawm tsam.
- Kev tswj tsis zoo ntawm ob qho proteins tuaj yeem ua rau ntau yam kab mob.
- Lawv yog tsim los ntawm cov amino acids.
Qhov txawv ntawm NFkb1 thiab NFkb2 yog dab tsi?
NFkb1 yog protein nyob rau hauv tib neeg encoded los ntawm NFkb1 noob, thaum NFkb2 yog protein nyob rau hauv tib neeg encoded los ntawm NFkb2 noob. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm NFkb1 thiab NFkb2. Tsis tas li ntawd, NFkb1 protein tag nrho-ntev daim ntawv ntawm P105 cotranslates rau hauv daim ntawv nquag P50. Ntawm qhov tod tes, NFkb2 protein puv-ntev daim ntawv P100 cotranslates rau hauv daim ntawv nquag P52.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm NFkb1 thiab NFkb2 hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – NFkb1 vs NFkb2
NFkb protein complex yog koom nrog hauv kev tswj kev hloov pauv ntawm DNA, cytokine ntau lawm, thiab cell ciaj sia. NFkb1 thiab NFkb2 proteins muaj nyob rau hauv chav kawm 1 NFkb protein tsev neeg. NFkb1 yog protein nyob rau hauv tib neeg encoded los ntawm NFkb1 noob, thaum NFkb2 yog protein nyob rau hauv tib neeg encoded los ntawm NFkb2 noob. Yog li, qhov no qhia txog qhov sib txawv ntawm NFkb1 thiab NFkb2.
