Qhov sib txawv tseem ceeb ntawm GABA thiab gabapentin yog GABA yog qhov tseem ceeb inhibitory neurotransmitter uas pab txhawb kev loj hlob thiab loj hlob ntawm cov tsiaj hauv nruab nrab paj hlwb, whereas gabapentin yog cov tshuaj uas tuaj yeem ua raws li cov txiaj ntsig ntawm GABA.
GABA thiab gabapentin yog tshuaj lom neeg, tab sis muaj qhov sib txawv ntawm lawv raws li lawv cov qauv tsim thiab kev siv.
GABA yog dab tsi?
Lub sij hawm GABA luv luv rau gamma-aminobutyric acid. Nws yog ib qho tseem ceeb inhibitory neurotransmitter uas muaj txiaj ntsig zoo hauv kev loj hlob thiab kev loj hlob ntawm cov tsiaj hauv nruab nrab paj hlwb. Lub luag haujlwm tseem ceeb ntawm qhov sib xyaw no yog txhawm rau txo cov kev tawm dag zog neuronal thoob plaws hauv lub paj hlwb.
Daim duab 01: Cov Qauv Tshuaj ntawm GABA
Raws li cov tshuaj tiv thaiv neurotransmitter, GABA tuaj hauv ob chav kawm xws li GABA-A thiab GABA-B. Hauv GABA-A, cov receptor yog ib feem ntawm ligand-gated ion channel complex, whereas nyob rau hauv GABA-B, metabotropic receptors qhib los yog kaw ion channels ntawm intermediates.
Feem ntau, cov neurons hu ua GABAergic neurons zoo li tsim GABA raws li cov txiaj ntsig ntawm cov neuron. Cov neurons no muaj lub luag haujlwm inhibitory ntawm cov receptors hauv cov neeg laus vertebrates. Ntawm cov neurons no, cov hlwb nruab nrab spiny yog ib qho piv txwv ntawm GABAergic neurons uas tshwm sim hauv nruab nrab paj hlwb.
Peb tuaj yeem soj ntsuam GABA tshwm sim raws li zwitterion muaj pawg carboxyl uas yog deprotonated thiab ib pawg amino uas yog protonated. Lub conformation ntawm cov khoom no nyob ntawm ib puag ncig. Piv txwv li, nyob rau hauv nws cov roj theem, nws muaj ib tug heev folded conformation uas yog heev txaus siab vim lub electrostatic attraction ntawm ob pawg functional.
Gabapentin yog dab tsi?
Gabapentin yog ib qho tshuaj tiv thaiv kab mob uas muaj txiaj ntsig zoo hauv kev kho mob qaug dab peg thiab mob neuropathic. Lub npe lag luam ntawm cov tshuaj no yog Neurontin. Txoj kev ntawm kev tswj hwm cov tshuaj no yog qhov ncauj. Cov tshuaj no yog nyob rau hauv chav kawm tshuaj ntawm gabapentinoid.
Daim duab 02: Cov Qauv Tshuaj ntawm Gabapentin
Lub bioavailability ntawm gabapentin yog li ntawm 27 mus rau 60%, uas tuaj yeem hloov pauv qhov sib npaug ntawm cov tshuaj. Lub peev xwm ntawm cov protein khi ntawm cov khoom no yog tsawg dua 3%. Thaum xav txog cov metabolism ntawm gabapentin, tsis muaj cov metabolism hauv cov khoom tseem ceeb, tab sis kev tshem tawm ib nrab-lub neej tuaj yeem muab tau li 5-7 teev. Kev tso tawm tuaj yeem tshwm sim los ntawm lub raum txoj kev.
Muaj qee qhov kev mob tshwm sim ntawm gabapentin, suav nrog kiv taub hau, tsaug zog, nkees, thiab peripheral edema. Txawm li cas los xij, nws tuaj yeem ua rau muaj kev xav tua tus kheej thiab coj tus cwj pwm. Kev noj tshuaj ntau dhau ntawm gabapentin tuaj yeem tshwm sim los ntawm kev noj ntau dhau, kev siv tshuaj ntau dhau. Cov tsos mob ntawm overdosing muaj xws li sedation, qhov muag tsis pom kev, hais lus slurred, thiab tsaug zog.
Qhov txawv ntawm GABA thiab Gabapentin yog dab tsi?
GABA thiab gabapentin yog tshuaj lom neeg ze rau ib leeg, tab sis lawv muaj qhov sib txawv ntawm lawv. e.g. Cov qauv tsim ntawm cov tshuaj sib xyaw ua ke, kev siv, thiab lwm yam. Qhov sib txawv ntawm GABA thiab gabapentin yog GABA yog ib qho inhibitory neurotransmitter uas muaj peev xwm tswj tau cov neuronal excitability nyob rau hauv nruab nrab paj hlwb, whereas gabapentin yog ib yam tshuaj uas muaj peev xwm ua raws li cov nyhuv ntawm GABA.
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm GABA thiab gabapentin hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – GABA vs Gabapentin
Lub sij hawm GABA sawv cev rau gamma-aminobutyric acid. Gabapentin yog ib qho tshuaj anticonvulsant uas siv los kho qhov qaug dab peg thiab mob neuropathic. Qhov sib txawv tseem ceeb ntawm GABA thiab gabapentin yog tias GABA yog ib qho inhibitory neurotransmitter uas tuaj yeem tswj cov neuronal excitability nyob rau hauv nruab nrab paj hlwb, whereas gabapentin yog ib yam tshuaj uas tuaj yeem ua raws li cov nyhuv ntawm GABA.
