Qhov sib txawv tseem ceeb ntawm qhov zoo thiab qhov tsis zoo ntawm allosterism yog qhov zoo allosterism hauv cov proteins qhia tau tias muaj kev sib raug zoo rau ligands, qhov tsis zoo allosterism hauv cov proteins qhia tias tsis muaj kev sib raug zoo rau ligands.
Allosterism lossis allosteric tus cwj pwm yog qhov tshwm sim uas cov haujlwm ntawm cov protein tuaj yeem hloov pauv nyob ntawm kev sib txuas ntawm qee cov molecules ntawm qhov chaw uas tsis yog qhov chaw nquag ntawm cov protein (tshwj xeeb hauv cov enzymes). Ib qho zoo allosterism qhia tau hais tias kev khi ntawm ib qho molecule effector rau ib qho enzyme ua rau lub enzyme hloov nws txoj kev teeb tsa rau hauv daim ntawv nquag. Nyob rau hauv sib piv, ib tug tsis zoo allosteirsm qhia hais tias ib tug effector molecule binding ua rau lub enzyme hloov nws configuration los ntawm ib tug active daim ntawv mus rau ib tug inactive daim ntawv.
Zoo Allosterism yog dab tsi?
Zoo allosterism yog qhov hloov pauv hauv kev teeb tsa ntawm cov protein (feem ntau yog ib qho enzyme) los ntawm daim ntawv tsis ua haujlwm mus rau daim ntawv ua haujlwm raws li kev khi ntawm ib qho effector molecule. Lub effector molecule khi nrog ib qho chaw uas tsis yog qhov chaw ua haujlwm ntawm enzyme; nws yog hu ua allosteric site. Cov txheej txheem no tseem hu ua allosteric activation.
Ib qho piv txwv rau xws li effector molecule binding yog kev sib txuas ntawm oxygen molecule nrog hemoglobin molecule, uas ua rau lub hemoglobin molecule kom zoo thauj oxygen mus rau cov hlwb. Nyob ntawd, cov pa oxygen molecule khi nrog ferrous hlau ntawm heme molecule nyob rau hauv hemoglobin molecule. Daim ntawv nquag hu ua oxy-hemoglobin, thaum daim ntawv tsis ua haujlwm yog hu ua deoxy-hemoglobin.
Dab tsi yog Allosterism?
Negative allosterism yog qhov kev hloov pauv ntawm kev teeb tsa ntawm ib qho enzyme los ntawm daim ntawv nquag mus rau daim ntawv tsis ua haujlwm raws li kev khi ntawm ib qho effector molecule. Lub effector molecule khi nrog ib qho chaw uas tsis yog qhov chaw ua haujlwm ntawm enzyme; nws yog hu ua allosteric site. Cov txheej txheem no tseem hu ua allosteric inhibition.
Daim duab 01: Zoo thiab tsis zoo Allosterism
Thaum tsis pom zoo allosterism, kev khi ntawm ib lub ligand txo qhov kev sib raug zoo ntawm cov enzyme rau substrate ntawm lwm qhov chaw muaj kev cuam tshuam rau substrate khi. Ib qho piv txwv yog kev khi ntawm 2, 3-BPG rau qhov chaw allosteric ntawm hemoglobin, uas ua rau txo qis hauv kev sib raug zoo rau cov pa oxygen ntawm tag nrho cov subunits.
Qhov txawv ntawm qhov zoo thiab qhov tsis zoo ntawm Allosterism yog dab tsi?
Nyob rau hauv qhov zoo allosterism, kev khi ntawm ib qho effector molecule rau ib qho enzyme ua rau cov enzyme hloov nws cov teeb tsa mus rau hauv daim ntawv nquag, thaum nyob rau hauv qhov tsis zoo allosterism, khi ntawm ib qho effector molecule ua rau lub enzyme hloov nws cov kev teeb tsa los ntawm kev nquag. daim ntawv mus rau hauv daim ntawv tsis ua haujlwm. Qhov sib txawv tseem ceeb ntawm qhov zoo thiab qhov tsis zoo ntawm allosterism yog qhov zoo allosterism nyob rau hauv cov proteins qhia tau hais tias muaj kev sib raug zoo siab rau ligands, qhov tsis zoo allosterism hauv cov proteins qhia tias tsis muaj kev sib raug zoo rau ligands. Tsis tas li ntawd, qhov zoo allosterism suav nrog kev ua kom muaj zog, qhov tsis zoo allosterism cuam tshuam nrog inhibition. Kev khi cov pa nrog hemoglobin yog ib qho piv txwv ntawm qhov zoo allosterism thaum khi ntawm 2, 3-BPG nrog hemoglobin yog ib qho piv txwv ntawm qhov tsis zoo allosterism.
Cov infographic hauv qab no nthuav tawm qhov sib txawv ntawm qhov zoo thiab qhov tsis zoo ntawm allosterism hauv daim ntawv teev npe rau kev sib piv ntawm ib sab.
Summary – Positive vs Negative Allosterism
Nyob rau hauv allosterism lossis allosteric tus cwj pwm, cov haujlwm ntawm cov protein tuaj yeem hloov pauv raws li kev khi ntawm qee cov molecules ntawm ib qhov chaw uas tsis yog qhov chaw nquag ntawm cov protein (tshwj xeeb hauv cov enzymes). Qhov sib txawv tseem ceeb ntawm qhov zoo thiab qhov tsis zoo ntawm allosterism yog qhov zoo allosterism nyob rau hauv cov proteins qhia tau hais tias muaj kev sib raug zoo siab rau ligands, qhov tsis zoo allosterism hauv cov proteins qhia tias tsis muaj kev sib raug zoo rau ligands.
