Qhov sib txawv tseem ceeb ntawm ferritin thiab hemoglobin yog tias ferritin yog ib qho chaw khaws cia hauv cellular metalloprotein uas khaws cov hlau thiab tso tawm raws li kev tswj hwm, thaum hemoglobin yog cov khoom thauj metalloprotein hauv cov qe ntshav liab uas thauj oxygen los ntawm lub cev.
Ferritin thiab hemoglobin yog ob qho tseem ceeb metalloproteins. Metalloproteins yog cov proteins uas muaj hlau ion cofactor. Cov ntsiab lus hlau no tuaj yeem yog hlau, tooj liab, cob alt, manganese, thiab lwm yam. Feem ntau ntawm cov protein muaj nyob hauv pawg no. Piv txwv li, muaj nyob ib ncig ntawm 3000 zinc metalloproteins hauv tib neeg. Yog li ntawd, metaproteins muaj ntau lub luag haujlwm hauv cov hlwb, suav nrog kev khaws cia, thauj, enzymes, teeb liab transduction proteins thiab tiv thaiv cov protein tiv thaiv kab mob.
Ferritin yog dab tsi?
Ferritin yog ib qho khoom siv thoob plaws hauv cellular cia metalloprotein uas khaws cov hlau thiab tso tawm. Cov protein no muaj nyob hauv yuav luag txhua yam kab mob nyob, suav nrog archaea, kab mob, algae, cov nroj tsuag siab dua, thiab tsiaj txhu. Yog li ntawd, nws yog thawj hlau cia protein nyob rau hauv prokaryotes thiab eukaryotes. Raws li txoj cai, ferritin yog globular protein uas muaj 24 protein subunits. Cov ferritin uas tsis ua ke nrog hlau yog hu ua apoferritin. Cov molecular loj ntawm cov protein no yog 474 kDa. Cov noob encoding rau cov protein no hauv tib neeg yog FTL thiab FTH.
Daim duab 01: Ferritin
Ferritin tuaj yeem khaws cov hlau hauv cov ntawv soluble thiab tsis muaj tshuaj lom. Nws yog ib qho tseem ceeb tsis txaus tiv thaiv cov hlau tsis txaus thiab hlau ntau dhau ntawm tib neeg. Ferritin yog cytosolic protein ntau hauv cov ntaub so ntswg. Txawm li cas los xij, ib qho me me tau tso rau hauv cov ntshav, yog li nws tuaj yeem ua tau raws li cov neeg nqa khoom hlau. Cov kws kho mob noj cov ntshav ferritin ua tus cim qhia tsis ncaj ntawm tag nrho cov nyiaj hlau khaws cia hauv lub cev. Yog li, kev kuaj ntshav ferritin yog siv los ua kev kuaj mob rau cov ntshav tsis muaj hlau tsis txaus. Cov qib ferritin ib txwm nyob rau hauv cov ntshav rau cov txiv neej yog 18-270 ng / mL, thaum cov poj niam, nws yog 30-160 ng / mL. Ntxiv mus, ferritin muaj ntau yam muaj txiaj ntsig zoo xws li kev khaws cia hlau, cov khoom siv hlau, kev ua ferroxidase, lub luag haujlwm hauv kev tiv thaiv kab mob thiab kev ntxhov siab, kev koom tes hauv oxidation thiab txo cov tshuaj tiv thaiv, thiab lwm yam.
Hemoglobin yog dab tsi?
Haemoglobin yog cov khoom thauj metalloprotein hauv cov qe ntshav liab uas thauj oxygen los ntawm lub cev. Nws muaj cov hlau thiab muaj nyob rau hauv yuav luag tag nrho cov vertebrates thiab ib co invertebrates. Lub hemoglobin nqa oxygen los ntawm lub ntsws los yog gills mus rau tag nrho lub cev. Tom qab ntawd nws tso tawm cov pa oxygen rau aerobic ua pa kom tsim lub zog rau kev ua haujlwm ntawm cov kab mob. Feem ntau, tus neeg noj qab haus huv muaj 20-30 grams hemoglobin hauv txhua 100 mL ntawm cov ntshav. Mammalian hemoglobin tuaj yeem nqa mus txog plaub lub pa oxygen molecules. Hemoglobin muaj peev xwm ua tau oxygen-binding ntawm 1.34 mL O2 ib gram. Tsis tas li ntawd, hemoglobin tseem koom nrog hauv kev thauj mus los ntawm lwm cov pa roj xws li CO 2 Nws kuj nqa nitrogen oxides..
Daim duab 02: Haemoglobin
Cells uas nqa hemoglobin ntxiv rau cov qe ntshav liab suav nrog A9 dopaminergic neurons, macrophages, alveolar cells, retinal pigment epithelium, hepatocytes, lub raum mesangial hlwb thiab endometrial hlwb. Hauv cov hlwb no, hemoglobin ua haujlwm ua antioxidant thiab tswj cov metabolism hauv hlau. Hemoglobinemia yog ib qho mob uas muaj ntau tshaj ntawm hemoglobin pom nyob rau hauv cov ntshav plasma vim qhov cuam tshuam ntawm intravascular hemolysis.
Dab tsi zoo sib xws ntawm Ferritin thiab hemoglobin?
- Ferritin thiab hemoglobin yog ob qho tseem ceeb metalloproteins.
- Lawv yog cov proteins uas ua los ntawm cov amino acids.
- Ob leeg yog cov proteins loj loj.
- Cov no muaj subunits.
- ob leeg muaj ntshav.
- Lawv ob leeg txuas nrog anemia.
- Lawv muaj nuj nqi ntawm nqa khoom.
Qhov txawv ntawm Ferritin thiab hemoglobin yog dab tsi?
Ferritin yog ib qho chaw khaws cia hauv cellular metalloprotein uas khaws cov hlau thiab tso tawm hauv kev tswj hwm, thaum hemoglobin yog cov khoom thauj metalloprotein hauv cov qe ntshav liab uas thauj cov pa oxygen hauv lub cev. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm ferritin thiab hemoglobin. Tsis tas li ntawd, ferritin muaj 24 subunits, thaum hemoglobin muaj 4 subunits.
Cov ntaub ntawv hauv qab no teev qhov sib txawv ntawm ferritin thiab hemoglobin hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – Ferritin vs Hemoglobin
Metalloproteins yog cov proteins uas raug khi los ntawm yam tsawg kawg ib qho hlau xws li hlau, tooj liab, cob alt, thiab manganese. Ferritin thiab hemoglobin yog ob qho tseem ceeb metalloproteins. Ferritin yog ib qho intracellular cia metalloprotein uas khaws cov hlau thiab tso tawm hauv kev tswj hwm, thaum hemoglobin yog cov khoom thauj metalloprotein hauv cov qe ntshav liab uas thauj oxygen los ntawm lub cev. Yog li, qhov no qhia txog qhov sib txawv ntawm ferritin thiab hemoglobin.
