Qhov sib txawv tseem ceeb ntawm cov tshuaj sympathomimetic thiab sympatholytic tshuaj yog cov tshuaj sympathomimetic yog cov tshuaj uas tuaj yeem txhim kho adrenergic muaj nuj nqi, whereas sympatholytic tshuaj yog cov tshuaj uas cuam tshuam adrenergic muaj nuj nqi.
Lub sij hawm adrenergic yog hais txog kev sib cuam tshuam ntawm cov proteins thiab tshuaj nrog adrenaline lossis noradrenaline, feem. Cov tshuaj Adrenergic yog cov tshuaj uas tuaj yeem ua rau cov hlab ntsha hauv peb lub cev ua rau lub paj hlwb.
Dab tsi yog tshuaj Sympathomimetic?
Sympathomimetic cov tshuaj yog ib hom tshuaj adrenergic uas yog siv los ua cov tshuaj stimulant uas qhia cov teebmeem ntawm endogenous agonists ntawm lub paj hlwb sympathetic. Cov tshuaj no tseem hu ua adrenergic tshuaj los yog adrenergic amines. Cov tshuaj no tseem ceeb hauv kev kho mob plawv nres thiab ntshav siab. Lawv kuj tuaj yeem kho tus mob qeeb ua haujlwm ntxov ntxov.
Ntxiv mus, muaj ntau lub tswv yim los ntawm cov tshuaj no tuaj yeem ua. Qee qhov ntawm cov txheej txheem no suav nrog kev ua kom ncaj qha ntawm postsynaptic receptors, thaiv, rhuav tshem thiab rov ua dua ntawm qee yam neurotransmitters, thiab txhawb kev tsim khoom thiab tso tawm catecholamines. Ntawm cov txheej txheem no, kev ua yeeb yam ncaj qha tshwm sim los ntawm alpha-adrenergic agonists, beta-adrenergic agonists, thiab dopaminergic agonists. Qhov kev tsis ncaj ncees tshwm sim los ntawm MAOIs, COMT inhibitors, tso tawm cov tshuaj stimulants, thiab lwm yam.
Qee yam piv txwv ntawm cov tshuaj sympathomimetic suav nrog amphetamine, benzylpiperazine, cathine, cathinone, cocaine, ephedrine, maprotiline, MDMA, thiab methcathinone.
Dab tsi yog tshuaj Sympatholytic?
Sympatholytic tshuaj yog ib hom tshuaj adrenergic uas tuaj yeem tawm tsam cov teebmeem hauv qab ntawm postganglionic hlab ntsha tawg. Cov hlab ntsha firings no tshwm sim nyob rau hauv lub cev muaj zog uas yog innervated los ntawm lub sympathetic paj hlwb. Ntxiv mus, cov tshuaj no tuaj yeem siv los ua cov tshuaj tiv thaiv hypertensive, ua tshuaj kho kev ntxhov siab, suav nrog kev ntxhov siab dav dav thiab kev ntxhov siab.
Thaum xav txog cov txheej txheem ntawm kev ua haujlwm, cov tshuaj no tuaj yeem cuam tshuam cov cim ntawm epinephrine thiab norepinephrine, inhibit adrenergic receptor signaling los ntawm kev thaiv cov synthesis ntawm catecholamines, los ntawm inhibiting VMAT, thiab ua rau lom rau sympathetic neurons, thiab lwm yam.
Kev siv cov tshuaj no suav nrog kev thaiv ganglion, periphery acting, centrally acting, kho kev ntxhov siab los ntawm kev ua raws li beta-blockers, thiab lwm yam. sympatholytic tshuaj kuj hu ua sympathoplegic tshuaj.
Qhov txawv ntawm Sympathomimetic thiab Sympatholytic Tshuaj yog dab tsi?
tshuaj Adrenergic yog cov tshuaj uas tuaj yeem ua rau cov hlab ntsha hauv lub cev ua rau lub paj hlwb. Qhov sib txawv tseem ceeb ntawm cov tshuaj sympathomimetic thiab sympatholytic yog tias cov tshuaj sympathomimetic yog cov tshuaj uas tuaj yeem txhim kho kev ua haujlwm ntawm adrenergic, thaum cov tshuaj sympatholytic yog cov tshuaj uas cuam tshuam rau adrenergic muaj nuj nqi. Amphetamine, benzylpiperazine, cathine, cathinone, cocaine, ephedrine, maprotiline, MDMA, thiab methcathinone yog ib co piv txwv ntawm cov tshuaj sympathomimetic, whereas prazosin, rescinnamine, reserpine, rilmenidine, mecamylamine, trimethaphancov piv txwv ntawm cov tshuaj muaj txiaj ntsig.
Ntxiv mus, cov tshuaj sympathomimetic ua los ntawm kev ua haujlwm ncaj qha ntawm postsynaptic receptors, thaiv, rhuav tshem thiab rov noj qee yam neurotransmitters, thiab txhawb kev tsim khoom thiab tso tawm catecholamines. Lub caij no, cov tshuaj sympatholytic ua los ntawm inhibition ntawm cov cim qhia ntawm epinephrine thiab norepinephrine, inhibition ntawm adrenergic receptor signaling los ntawm kev thaiv cov synthesis ntawm catecholamines, los ntawm inhibition ntawm VMAT, los ntawm kev ua kuab lom rau sympathetic neurons, thiab lwm yam.
Cov infographic hauv qab no teev qhov sib txawv ntawm cov tshuaj sympathomimetic thiab sympatholytic tshuaj nyob rau hauv daim ntawv teev npe rau ib sab ntawm kev sib piv
Summary – Sympathomimetic vs Sympatholytic Drugs
tshuaj Adrenergic yog cov tshuaj uas tuaj yeem ua rau cov hlab ntsha hauv lub cev ua rau lub paj hlwb. Qhov sib txawv tseem ceeb ntawm sympathomimetic thiab sympatholytic tshuaj yog cov tshuaj sympathomimetic yog cov tshuaj uas tuaj yeem txhim kho adrenergic muaj nuj nqi, hos sympatholytic tshuaj yog cov tshuaj uas cuam tshuam adrenergic muaj nuj nqi..
