Qhov sib txawv tseem ceeb ntawm cov qog qog hlwb thiab micrometastases yog cov qog hlwb uas cais tawm yog cov qog hlwb ib leeg lossis cov qog cell pawg uas tsis loj dua 0.2 hli thaum micrometastases yog cov khoom me me ntawm cov qog hlwb uas tsis loj dua. 2 mm loj.
Nyob rau hauv cov txheej txheem ntawm metastasis, cov qog nqaij hlav cancer tawg tawm ntawm cov qog nqaij hlav thawj zaug thiab taug kev los ntawm cov ntshav lossis cov qog ntshav. Tom qab ntawd, cov hlwb no tsim cov qog tshiab hauv lwm qhov ntawm lub cev. Metastatic cancer yog tib hom mob qog noj ntshav raws li cov qog thawj. Metastasis feem ntau txawv los ntawm kev cuam tshuam mob qog noj ntshav. Cov qog hlwb cais tawm thiab micrometastases yog ob hom qog hlwb cuam tshuam nrog metastasis.
Dab tsi yog Isolated Tumor Cells?
Isolated qog hlwb (ITCs) yog ib leeg qog hlwb lossis qog cell pawg uas tsis loj dua 0.2 hli. Cov qog hlwb cais tawm muaj cov yam ntxwv zoo ib yam. Lawv tsis muaj kev ua haujlwm tsis zoo (xws li, tsis muaj kev loj hlob thiab tsis muaj cov tshuaj tiv thaiv stromal) thiab nyob rau hauv cov lymphatic sinuses. Tus cim "i" yog siv los qhia cov qog hlwb uas feem ntau kuaj pom los ntawm immunohistochemistry thiab tuaj yeem tshawb xyuas nrog hematoxylin thiab eosin (H&E) statin. Raws li American Joint Committee on cancer (AJSS) staging manual definition, cais cov qog hlwb tsis ntau tshaj 0.2 hli thiab feem ntau yog kuaj los ntawm immunohistochemistry (IHC) los yog molecular txoj kev. Yog li ntawd, localization tsis yog ib qho txheej txheem rau kev txhais cov qog nqaij hlav hauv cov lus saum toj no. Tsis tas li ntawd, cov qog nqaij hlav cais tau qhia tias pN0[i+].
Daim duab 01: Cov qog nqaij hlav cais tawm
Ib leeg qog hlwb tseem hu ua circulating qog cells. Feem ntau ntawm cov qog nqaij hlav los yog cov qog nqaij hlav qog tsis ua tiav metastasize. Tsuas yog ob peb lub qog nqaij hlav (0.05%) muaj sia nyob thiab pib ua kom pom tseeb metastatic. Thaum cais cov qog hlwb ua tiav tsaws rau ntawm ib qho chaw nyob deb thiab tsim, lawv hu ua disseminated qog cells (DTCs).
YMicrometastases yog dab tsi?
Micrometastases yog ib qho me me ntawm cov qog hlwb loj dua 0.2 hli tab sis tsis ntau dua 2 hli. Lawv feem ntau qhia extravasation. Qhov no txhais tau tias lawv ntxeem tau thiab nkag mus rau cov hlab ntsha lymphatic lossis lymphatic sinus phab ntsa. Lawv tuaj yeem kis mus rau lwm qhov ntawm lub cev los ntawm lymphovascular system.
Daim duab 02: Micrometastases
Micrometastases ib txwm muaj tsawg heev. Yog li, lawv tsis tuaj yeem pom nrog kev kuaj pom xws li mammograms, MRI, ultrasound, PET, lossis CT scans. Lawv tuaj yeem raug txheeb xyuas los ntawm hematoxylin thiab eosin staining. Kev kuaj pom ntawm micrometastases hauv cov qog ntshav qog ntshav tuaj yeem ua tiav los ntawm kev kos duab. Yog tias cov micrometastases muaj nyob rau hauv cov qog ntshav qog ntshav, txoj kev kho mob yog tshem tawm cov nodes phais. Nyob ntawm qhov kev mob qog noj ntshav, tus kws phais yuav txiav txim siab txog theem ntawm kev txiav.
Dab tsi zoo sib xws ntawm Isolated qog Cells thiab Micrometastases?
- Ib leeg qog hlwb thiab micrometastases yog ob hom qog hlwb cuam tshuam nrog metastasis.
- Lawv yog pawg ntawm cov qog hlwb.
- Ob hom tuaj yeem txheeb xyuas tau hauv cov kab mob lymphatic.
- Cov no tej zaum yuav muaj qhov tseem ceeb prognostic thiab kho tus nqi hauv kev kho mob qog noj ntshav.
Dab tsi yog qhov txawv ntawm Isolated qog Cells thiab Micrometastases?
Cov qog nqaij hlav cais tawm yog cov qog qog ib leeg lossis cov qog hlwb uas tsis ntau dua 0.2 hli qhov loj me thaum micrometastases yog cov khoom me me ntawm cov qog hlwb loj dua 0.2 hli tab sis tsis ntau dua 2 hli. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm cov qog hlwb cais thiab micrometastases. Tsis tas li ntawd, cov qog nqaij hlav cais nyob hauv lymphatic sinuses, thaum micrometastases nyob sab nraud ntawm lymphatic sinuses.
Cov hauv qab no infographic teev qhov sib txawv ntawm cov qog hlwb cais thiab micrometastases hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Isolated Tumor Cells vs Micrometastases
Nyob rau hauv metastasis, cov qog nqaij hlav cancer tawg thiab taug kev deb ntawm qhov chaw uas lawv tau tsim thawj zaug. Cov qog hlwb cais tawm thiab micrometastases yog ob hom qog hlwb cuam tshuam nrog metastasis. Cov kab mob cais tawm yog cov qog nqaij hlav ib leeg lossis cov qog hlwb uas tsis loj dua 0.2 hli. Micrometastases yog ib qho me me ntawm cov qog hlwb uas nyob nruab nrab ntawm 0.2 hli txog 2 hli. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm cov qog hlwb cais thiab micrometastases.
