Qhov sib txawv tseem ceeb ntawm polymyxin B thiab colistin yog tias polymyxin B yog qhov tseem ceeb rau kev kho cov kab mob hauv lub qhov muag, hos colistin tseem ceeb rau kev kho mob ntawm ntau cov tshuaj tiv thaiv kab mob Gram-negative.
Ob leeg polymyxin B thiab colistin yog cov tshuaj tua kab mob zoo. Cov tshuaj tua kab mob yog cov tshuaj uas tuaj yeem cuam tshuam kev loj hlob lossis rhuav tshem cov kab mob. Ob yam tshuaj no tseem ceeb hauv kev kho cov kab mob kab mob. Colistin tseem hu ua polymyxin E.
Polymyxin B yog dab tsi?
Polymyxin B yog tshuaj tua kab mob uas muaj txiaj ntsig zoo hauv kev kho cov kab mob kab mob. Daim ntawv ophthalmic ntawm cov tshuaj no muaj txiaj ntsig zoo hauv kev kho cov kab mob ntawm lub qhov muag. Muaj ob peb txoj hauv kev uas peb tuaj yeem tau txais cov tshuaj no; txhaj tshuaj rau hauv cov leeg los yog raws li kev txhaj tshuaj rau hauv cov leeg, txhaj rau hauv cov leeg txha caj qaum, lossis raws li tee rau hauv qhov muag.
Cov kev mob tshwm sim feem ntau ntawm polymyxin B yog kub hnyiab, stinging, khaus, khaus, liab, tsis pom kev, daim tawv muag khaus, tearing, daim tawv muag o los yog crusting, thiab rhiab heev rau lub teeb.
Mechanism of Action of Polymyxin B
Feem ntau, cov tshuaj polymyxin B qhia nws cov tshuaj tiv thaiv kab mob los ntawm cov tshuaj ntxuav tes cationic ntawm cov cell membranes. Nyob ntawd, cov tshuaj no zoo li khi nrog qhov chaw tsis zoo ntawm cov lipopolysaccharide txheej ntawm cov kab mob ntawm tes, los ntawm cov txheej txheem electrostatic affinity, yog li, ua rau tua cov kab mob ntawd.
Colistin yog dab tsi?
Colistin yog tshuaj tua kab mob muaj txiaj ntsig zoo li kev kho mob zaum kawg rau cov kab mob Gram-negative multidrug-resistant. Ib qho kab mob zoo li no yog mob ntsws. Cov tshuaj no kuj muaj npe hu ua polymyxin E. Cov kab mob uas peb siv tau cov tshuaj no muaj xws li Pseudomonas aeruginosa, Kiebsiella pneumoniae, thiab Acinetobacter. Cov txheej txheem ntawm kev tswj hwm ntawm cov tshuaj no suav nrog kev txhaj tshuaj rau hauv cov hlab ntsha, txhaj rau hauv cov leeg lossis nqus pa (cov tshuaj tseem hu ua colistimethate sodium hauv cov xwm txheej zoo li no), siv rau ntawm daim tawv nqaij lossis noj los ntawm qhov ncauj (hauv kev tswj hwm qhov ncauj, tshuaj. yog lub npe hu ua colistin sulfate).
Txawm li cas los xij, tuaj yeem muaj qee qhov kev mob tshwm sim ntawm colistin. Cov ntawv txhaj tshuaj ntawm cov tshuaj no muaj xws li cov kev mob tshwm sim xws li teeb meem raum thiab cov teeb meem neurological. Nws tuaj yeem muaj qee yam kev mob tshwm sim, suav nrog anaphylaxis, cov leeg tsis muaj zog, thiab raws plab. Kev tsim kho ntawm bronchioles yog ib qho kev mob tshwm sim los ntawm kev nqus cov tshuaj colistin.
Daim duab 01: Cov Qauv Tshuaj ntawm Colistin
Mechanism of Action of Colistin
Thaum xav txog cov txheej txheem ntawm kev ua ntawm colistin, nws yog polycationic peptide muaj ob qho tib si hydrophilic thiab lipophilic moieties. Cov cheeb tsam no zoo li cuam tshuam nrog cov kab mob sab nraud los ntawm kev hloov cov magnesium thiab calcium cov kab mob hauv cov lipopolysaccharide. Cov cheeb tsam hydrophilic/hydrophobic no tuaj yeem cuam tshuam nrog cytoplasmic membrane zoo ib yam li cov tshuaj ntxuav tes, solubilizing daim nyias nyias nyob rau hauv ib qho chaw aqueous uas yog cov kab mob bactericidal.
Dab tsi zoo sib xws ntawm Polymyxin B thiab Colistin?
- Ob leeg polymyxin B thiab colistin yog cov tshuaj tua kab mob zoo. Cov tshuaj tua kab mob yog cov tshuaj uas tuaj yeem cuam tshuam kev loj hlob lossis rhuav tshem cov kab mob.
- Ob cov tshuaj no tseem ceeb hauv kev kho kab mob kab mob.
Qhov txawv ntawm Polymyxin B thiab Colistin yog dab tsi?
Qhov sib txawv tseem ceeb ntawm polymyxin B thiab colistin yog tias polymyxin B yog qhov tseem ceeb hauv kev kho cov kab mob hauv lub qhov muag, hos colistin tseem ceeb rau kev kho mob ntawm ntau cov tshuaj tiv thaiv kab mob Gram-negative. Qee cov kev mob tshwm sim ntawm polymyxin B cuam tshuam nrog kub hnyiab, stinging, khaus, khaus, liab, pom tsis pom kev, daim tawv muag khaus, tearing, daim tawv muag o los yog crusting, thiab rhiab heev rau lub teeb, thiab lwm yam, whereas cov kev phiv ntawm polymyxin feem ntau cuam tshuam nrog rau lub raum teeb meem, thiab neurological teeb meem., anaphylaxis, leeg tsis muaj zog, thiab raws plab.
Hauv qab no yog cov ntsiab lus ntawm qhov sib txawv tseem ceeb ntawm polymyxin B thiab colistin hauv daim ntawv tabular.
Summary – Polymyxin B vs Colistin
Ob leeg polymyxin B thiab colistin yog cov tshuaj tua kab mob zoo. Cov tshuaj tua kab mob yog cov tshuaj uas tuaj yeem cuam tshuam kev loj hlob lossis rhuav tshem cov kab mob. Ob cov tshuaj no yog ib qho tseem ceeb hauv kev kho cov kab mob. Qhov sib txawv tseem ceeb ntawm polymyxin B thiab colistin yog tias polymyxin B yog qhov tseem ceeb rau kev kho cov kab mob hauv lub qhov muag thaum colistin tseem ceeb rau kev kho mob ntawm ntau cov tshuaj tiv thaiv kab mob Gram-negative.
