Qhov sib txawv tseem ceeb ntawm mRNA thiab tshuaj tiv thaiv adenovirus yog tias cov tshuaj tiv thaiv mRNA feem ntau muaj cov ntawv luam ntawm mRNA nrog cov tshuaj tiv thaiv, thaum cov tshuaj tiv thaiv adenovirus muaj cov kab mob tsis muaj mob uas encodes tus kab mob spike protein.
Tshuaj tiv thaiv kab mob tiv thaiv kab mob. Cov no pab lub cev tiv thaiv kab mob los tsim cov hlwb tsim nyog thiab cov proteins los tawm tsam cov kab mob thaum lawv hla tus kab mob. Cov tshuaj tiv thaiv tuaj yeem txhaj rau hauv cov leeg nqaij lossis tuaj yeem muab tshuaj rau qhov ncauj. mRNA thiab adenovirus cov tshuaj tiv thaiv ob leeg tiv thaiv kab mob ua pa. Ob DNA lossis RNA raug xa mus rau koj lub hlwb, txhawb lub hlwb los tsim cov kab mob pathogens. Cov proteins no ua rau lub cev tsis muaj zog los tsim kev tiv thaiv kab mob.
Tshuaj tiv thaiv mRNA yog dab tsi?
mRNA tshuaj tiv thaiv, tseem hu ua messenger RNA tshuaj tiv thaiv, yog hom tshuaj tiv thaiv uas siv ib daim qauv ntawm mRNA los tsim cov tshuaj tiv thaiv kab mob. mRNA tshuaj tiv thaiv yog ib hom tshuaj tiv thaiv kab mob sib kis xws li kab mob khaub thuas, kab mob Zika, kab mob rabies, Covid 19 thiab ntau ntxiv. Cov tshuaj tiv thaiv mRNA kuj tseem siv los tiv thaiv qog noj ntshav. Cov tshuaj tiv thaiv kab mob Dendritic cell thiab lwm hom kev txhaj tshuaj ncaj qha mRNA tau siv rau hauv kev sim tshuaj qog noj ntshav. mRNA yog ntxiv rau ib qho ntawm DNA strands ntawm cov noob. Zoo ib yam li DNA, cov ntaub ntawv caj ces ntawm mRNA tau muab zais rau hauv cov kab ke nucleotide.
Cov tshuaj tiv thaiv mRNA txhob txwm tshaj tawm cov hluavtaws RNA rau hauv lub cev tiv thaiv kab mob lossis cov hlwb dendritic. Ib zaug hauv lub cev tiv thaiv kab mob, RNA ntawm cov tshuaj tiv thaiv ua raws li mRNA. Qhov no ua rau cov hlwb tsim cov protein txawv teb chaws uas ib txwm tsim los ntawm cov kab mob xws li kab mob lossis kab mob qog noj ntshav. Cov protein molecules no txhawb kev hloov kho lub cev tiv thaiv kab mob. Qhov no yuav pab lub cev txheeb xyuas thiab rhuav tshem cov kab mob sib xws (tus kab mob) lossis kab mob qog noj ntshav.
Daim duab 01: mRNA Tshuaj tiv thaiv
mRNA tshuaj tiv thaiv ua haujlwm txawv ntawm lwm cov tshuaj tiv thaiv. Cov tshuaj tiv thaiv feem ntau txhawb cov tshuaj tiv thaiv kab mob los ntawm kev txhaj tshuaj antigens. Cov antigens no tau npaj thiab loj hlob sab nraum lub cev. Tab sis, cov tshuaj tiv thaiv mRNA qhia txog lub neej luv luv nucleoside-hloov mRNA (modRNA) ntawm tus kab mob rau hauv tus neeg txhaj tshuaj. modRNA yog ib qho kev sib txuas ua ke ntawm RNA ib ntus. Txij li thaum cov antigens tsim nyob rau hauv lub host cell, nws stimulates cellular thiab humoral tiv thaiv.
Tshuaj Tiv Thaiv Adenovirus yog dab tsi?
tshuaj tiv thaiv Adenovirus yog tshuaj tiv thaiv kab mob adenovirus. Tus kab mob Adenovirus yog ib qho kab mob uas tshwm sim hauv lub ntsws. Tsis tas li ntawd, adenovirus yog ib hom kab mob DNA ob leeg. Cov tshuaj tiv thaiv no qhia txog kev tiv thaiv kab mob adenovirus serotypes 4 thiab 7. Serotypes yog qhov txawv ntawm cov kab mob, kab mob lossis cov kab mob tiv thaiv kab mob ntawm ntau tus neeg. Serotypes 4 thiab 7 feem ntau cuam tshuam nrog cov kab mob ua pa. Cov tshuaj tiv thaiv kab mob Adenovirus yog siv los ntawm qhov ncauj thiab muaj tus kab mob nyob. Cov ntsiav tshuaj tshuaj tiv thaiv no feem ntau yog coated kom tus kab mob kis tau los ntawm lub plab thiab kis mus rau cov hnyuv. Qhov no txhawb kev tiv thaiv kab mob.
Daim duab 02 Adenovirus
tshuaj tiv thaiv kab mob Adenovirus yog tshuaj tiv thaiv kab mob HIV, Ebola virus, Influenza virus, Covid 19, Mycobacterium tuberculosis thiab Plasmodium falciparum. Cov tshuaj tiv thaiv no yog tsim los ntawm kev ntxig lub tshuab hloov pauv mus rau hauv adenovirus. Qhov no yog ua los ntawm ncaj qha cloning los yog homologous recombination. Lub transgene cassette yog ib hom xov tooj ntawm tes genetic yam uas muaj qhov chaw recombinant thiab cov noob. Cov transgene cassettes qhia cov antigen uas yog tsom. Qhov no tshwm sim nyob rau hauv kev tswj ntawm ib tug muaj zog txhawb zog uas tuav ib tug muaj zog thiab ruaj khov qhia ntawm cov transgene.
Dab tsi yog Qhov Zoo Sib Txawv Ntawm mRNA thiab Adenovirus Vaccine?
- Ob qho tshuaj tiv thaiv mRNA thiab tshuaj tiv thaiv kab mob adenovirus ua haujlwm nrog cov khoom siv caj ces uas encodes cov noob ntawm cov kab mob mus rau hauv cov hlwb thiab tau txais lawv los ua cov protein tshwj xeeb ntawm cov kab mob.
- Cov tshuaj tiv thaiv no tau muab rau cov kab mob ua pa.
Qhov txawv ntawm mRNA thiab Adenovirus Vaccine yog dab tsi?
Qhov sib txawv tseem ceeb ntawm mRNA thiab tshuaj tiv thaiv adenovirus yog tias cov tshuaj tiv thaiv mRNA feem ntau muaj cov ntawv luam ntawm mRNA nrog lub plhaub tshuaj tiv thaiv, thaum cov tshuaj tiv thaiv adenovirus muaj cov kab mob tsis muaj mob uas encodes tus kab mob spike protein.mRNA tshuaj tiv thaiv yog ib qho tshuaj tiv thaiv kab mob sib kis xws li kab mob khaub thuas, kab mob Zika, kab mob rabies, Covid 19 thiab zoo li mob qog noj ntshav. Adenovirus vaccine yog ib hom tshuaj tiv thaiv kab mob ua pa. Nws kuj tseem tiv thaiv kab mob HIV, Ebola, kab mob khaub thuas, Covid 19, Mycobacterium tuberculosis thiab Plasmodium falciparum. Ntxiv mus, cov tshuaj tiv thaiv mRNA yog txhaj ncaj qha rau hauv cov leeg, thaum adenovirus tau muab rau qhov ncauj. Tsis tas li ntawd, cov tshuaj tiv thaiv mRNA yooj yim tsim dua li cov tshuaj tiv thaiv kab mob los yog cov kab mob attenuated. Kev nrawm ntawm kev tsim thiab tsim cov tshuaj tiv thaiv mRNA siab dua li cov tshuaj tiv thaiv adenovirus.
Cov infographic hauv qab no sawv cev qhov sib txawv ntawm mRNA thiab tshuaj tiv thaiv adenovirus.
Summary – mRNA vs Adenovirus Vaccine
mRNA tshuaj tiv thaiv yog hom tshuaj tiv thaiv uas siv ib daim qauv ntawm mRNA los tsim cov tshuaj tiv thaiv kab mob hloov pauv.mRNA yog ntxiv rau ib qho ntawm cov DNA ntawm cov noob. Ntawm no, cov tshuaj tiv thaiv mRNA qhia txog mRNA encoding kab mob tshwj xeeb antigens thiab txhawb nqa cov protein synthesis ntawm cov tswv tsev cell los tsim cov antigens. Qhov no ua rau lub cev tiv thaiv kab mob. Cov tshuaj tiv thaiv kab mob Adenovirus yog cov tshuaj ntsiav tshuaj uas muaj cov kab mob nyob. Nws feem ntau ua rau cov kab mob adenovirus. Adenovirus yog ib hom kab mob DNA ob leeg, thiab nws yog hom tshwj xeeb, yog li muaj ntau yam serotypes rau ntau hom. Lub capsule ntawm adenovirus feem ntau yog coated kom tus kab mob kis tau los ntawm lub plab, ua rau muaj kab mob hauv cov hnyuv. Qhov no txhawb kev tiv thaiv kab mob. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm mRNA thiab tshuaj tiv thaiv adenovirus
