Qhov sib txawv tseem ceeb ntawm VEGF thiab EGFR yog VEGF yog ib qho kev qhia cov protein uas txhawb kev loj hlob ntawm cov hlab ntsha tshiab thiab rov qab muab cov ntshav rau cov hlwb thiab cov ntaub so ntswg, thaum EGFR yog cov protein ntau transmembrane uas txhawb nqa DNA synthesis thiab cell proliferation.
VEGF thiab EGFR yog cov proteins uas cuam tshuam nrog cov cim qhia sib txawv hauv lub cev. Lawv ua cov haujlwm sib txawv uas tseem ceeb heev rau hemostasis. Vascular endothelial kev loj hlob yam yog ib qho kev qhia cov protein. Ib lub luag haujlwm tseem ceeb ntawm cov protein no yog tsim cov hlab ntsha tshiab. Nws kuj txhawb kev loj hlob ntawm cov hlab ntsha tshiab tom qab raug mob. Ntawm qhov tod tes, epidermal growth factor receptor yog transmembrane protein uas ua raws li receptor rau cov tswv cuab ntawm tsev neeg epidermal growth factor (EGF tsev neeg). Nws lub luag haujlwm tseem ceeb yog stimulation ntawm cell proliferation.
VEGF yog dab tsi?
Vascular endothelial kev loj hlob yam, Ameslikas hu ua vascular permeability factor (VPF), yog lub teeb liab protein. Nws yog tsim los ntawm fibroblasts hlwb. Nws txhawb kev tsim cov hlab ntsha tshiab. Lawv yog cov tseem ceeb heev signaling proteins. Lawv koom nrog hauv ob qho tib si vasculogenesis thiab angiogenesis. Nws yog ib feem ntawm lub cev uas muab cov pa oxygen rau cov khoom hauv lub cev thaum cov ntshav tsis txaus (hypoxia). Cov ntshav concentration ntawm VEGF yog siab nyob rau hauv tej yam kev mob xws li bronchial hawb pob thiab ntshav qab zib mellitus. Lub luag haujlwm ntawm VEGF yog tsim cov hlab ntsha tshiab thaum lub sij hawm embryonic txoj kev loj hlob. Nws kuj tseem koom nrog hauv cov hlab ntsha tshiab tsim tom qab raug mob, cov leeg nqaij 'kev ua si tom qab qoj ib ce, thiab cov hlab ntsha tshiab tsim (kev sib koom ua ke) kom hla cov hlab ntsha.
Figure 01: VEGF
Nws kuj tuaj yeem ua rau muaj kab mob. Cov qog nqaij hlav uas tuaj yeem nthuav qhia VEGF tuaj yeem loj hlob thiab metastasize. Lub overexpression ntawm VEGF tuaj yeem ua rau cov kab mob vascular hauv retina ntawm lub qhov muag thiab lwm qhov ntawm lub cev. Cov tshuaj xws li aflibercept, bevacizumab, ranibizumab, thiab pegaptanib tuaj yeem cuam tshuam qhov overexpression ntawm VEGF.
EGFR yog dab tsi?
EGFR receptor (epidermal growth factor receptor) yog ib tug tswv cuab ntawm tsev neeg ErbB receptor. Nws yog ib qho transmembrane protein feem ntau koom nrog hauv cell proliferation. Stanley Cohen tau tshawb pom qhov kev loj hlob ntawm epidermal thiab nws cov receptor, thiab nws yeej qhov khoom plig Nobel rau nws xyoo 1986. Epidermal growth factor receptor (EGFR) yog qhib los ntawm kev khi ntawm nws cov ligands tshwj xeeb, nrog rau cov kab mob epidermal loj hlob thiab hloov kev loj hlob α (TGFα).). Thaum ua kom tiav, EGFR nkag mus rau hauv daim ntawv tsis muaj zog monomeric rau active dimeric daim ntawv.
Figure 02: EGFR
EGFR dimerization txhawb nqa autophosphorylation ntawm ob peb tyrosine residues hauv C-terminal domain ntawm EGFR. Tsis tas li ntawd, autophosphorylation ua rau qee qhov kev taw qhia qis qis qis uas thaum kawg qhib qee cov teeb liab hloov pauv xws li MAPK, Akt thiab JNK txoj hauv kev. Tag nrho cov tshuaj tiv thaiv no ua rau DNA synthesis thiab cell proliferation. Kev qhia tsis txaus ntawm EGFR yog txuam nrog cov kab mob xws li Alzheimer's disease. Nyob rau hauv sib piv, overexpression yog txuam nrog kev loj hlob ntawm qog.
VEGF thiab EGFR yog dab tsi?
- ob leeg yog cov protein.
- Ob leeg koom nrog hauv kev taw qhia kev tshwm sim.
- Lawv ob leeg ua rau mob qog noj ntshav tom qab overexpression.
- Lawv cov dej num tseem ceeb heev rau homeostasis.
- Ob leeg muaj inhibitors los tswj lawv cov lus tshaj tawm.
Qhov txawv ntawm VEGF thiab EGFR yog dab tsi?
Cov vascular endothelial kev loj hlob zoo yog ib qho kev qhia cov protein uas txhawb kev loj hlob ntawm cov hlab ntsha tshiab thiab rov qab muab cov ntshav rau cov hlwb thiab cov ntaub so ntswg. Ntawm qhov tod tes, tus kab mob epidermal loj hlob receptor yog ib qho transmembrane protein uas txhawb nqa DNA synthesis thiab cell proliferation. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm VEGF thiab EGFR. Ntxiv mus, VEGF yog plasma protein. Nyob rau hauv sib piv, EGFR yog ib tug transmembrane protein. Yog li, qhov no kuj yog qhov sib txawv tseem ceeb ntawm VEGF thiab EGFR. Tsis tas li ntawd, VEGF yog tsim los ntawm fibroblast hlwb thaum EGFR yog tsim los ntawm epithelial hlwb.
Cov hauv qab no infographic teev qhov sib txawv ntawm VEGF thiab EGFR hauv daim ntawv teev npe.
Summary – VEGF vs EGFR
Vascular endothelial growth factor (VEGF) thiab epidermal growth factor receptor (EGFR) inhibitors tau dhau los ua cov kev kho tseem ceeb hauv ntau hom mob qog noj ntshav hauv xyoo tas los no. Lawv yog ob qho tib si tseem ceeb cov proteins hauv tib neeg lub cev uas koom nrog hauv kev taw qhia cov tshuaj tiv thaiv. Vascular endothelial kev loj hlob zoo tshaj plaws txhawb kev loj hlob ntawm cov hlab ntsha tshiab. Epidermal kev loj hlob zoo receptor nkoos DNA synthesis thiab cell proliferation. Overexpression ntawm ob qho tib si ntawm cov proteins no ua rau qee yam kab mob hauv tib neeg. Qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm VEGF thiab EGFR.
