Qhov sib txawv tseem ceeb ntawm brucine thiab strychnine yog tias brucine tsis muaj tshuaj lom dua li strychnine.
Brucine thiab strychnine yog ob hom alkaloids uas muaj qee yam tshuaj lom. Ib qho alkaloid yog ib txwm tshwm sim hauv tsev neeg cov organic compounds uas muaj tshuaj lom neeg nrog tsawg kawg ib qho nitrogen atom ib molecule. Cov tswv cuab ntawm pawg no muaj qee qhov sib txuas uas muaj cov khoom nruab nrab lossis tsis muaj zog acidic.
Brucine yog dab tsi?
Brucine yog ib qho alkaloid uas feem ntau pom nyob rau hauv tsob ntoo Strychnos nux-vomica. Nws yog ze ze rau strychnine, thiab feem ntau yog noj nrog strychnine; Yog li, brucine lom yog tsawg. Tsis tas li ntawd, brucine yog qhov sib piv tsis tshua muaj tshuaj lom. Cov tshuaj no muaj txiaj ntsig zoo li lub cuab yeej rau cov tshuaj stereospecific syntheses.
Cov tshuaj formula ntawm brucine yog C23H26N2O4. Cov molar loj ntawm cov tshuaj no yog 394.471 g / mol. Brucine tau pom thawj zaug los ntawm Pelletier thiab Caventou hauv 1819 siv cov tawv ntoo ntawm tsob ntoo, Strychnos nux-vomica. Txawm li cas los xij, cov qauv ntawm qhov sib xyaw no tau kwv yees tom qab xyoo 1889 los ntawm Hanssen. Nws hloov dua siab tshiab brucine thiab strychnine rau hauv tib lub molecule.
Thaum xav txog kev txheeb xyuas qhov tseeb ntawm brucine, peb tuaj yeem kuaj pom nws thiab ntsuas qhov sib xyaw ua ke ntawm cov kua chromatography thiab huab hwm coj spectrometry. Txawm li cas los xij, qhov sib xyaw no tau sib txawv los ntawm kev sib raug zoo ntawm strychnine nyob rau hauv thaum ntxov lub sij hawm siv cov reactivity ntawm chromic acid.
Muaj ntau ntau yam kev siv ntawm brucine tshuaj compounds nrog rau nws cov tshuaj siv xws li ib tug loj chiral molecule nyob rau hauv chiral daws, kev kho mob daim ntawv thov xws li siv nws raws li kev kho mob rau mob qog noj ntshav thiab raws li ib tug analgesic neeg sawv cev, thiab lwm yam.
Kev mob ntshav qab zib brucine yog qhov xwm txheej tsis tshua muaj. Qhov no yog vim hais tias cov compound no tau yooj yim noj nrog strychnine. Txawm li cas los xij, cov tsos mob ntawm brucine tuaj yeem raug txheeb xyuas tias yog cov leeg nqaij, convulsions, thiab mob raum raug mob. Cov tshuaj no tuaj yeem ua tus antagonist ntawm glycine receptors ua raws li kev tuag tes tuag taw inhibitory neurons.
Strychnine yog dab tsi?
Strychnine yog crystalline alkaloid compound uas muaj txiaj ntsig zoo li tshuaj tua kab. Nws yog ib qho tshuaj lom heev, tsis muaj xim uas muaj qhov tsw qab. Tshwj xeeb, cov tshuaj no tuaj yeem tua cov kab mob me me, suav nrog cov noog thiab nas. Yog tias peb nqus tau cov tshuaj no los yog nqos los yog nqus los ntawm qhov muag lossis qhov ncauj, nws tuaj yeem ua rau muaj tshuaj lom uas tuaj yeem ua rau cov leeg pob txha. Cov tshuaj lom no tuaj yeem ua rau tuag taus los ntawm asphyxia. Qhov feem ntau ntawm strychnine yog cov noob ntawm Strychnos nux-vomica ntoo.
Cov tshuaj formula ntawm strychnine yog C21H22N2O2, thiab molar mass yog 334.419 g / mol. Cov tshuaj no tshwm sim li dawb los yog translucent crystals los yog raws li ib tug crystalline hmoov muaj ib tug iab saj. Thaum xav txog cov txheej txheem ntawm kev txiav txim ntawm strychnine, nws ua raws li cov neurotoxin muaj antagonist zog ntawm glycine thiab acetylcholine receptors. Feem ntau, cov khoom no cuam tshuam rau lub cev muaj zog paj hlwb nyob rau hauv tus txha caj qaum uas tswj cov leeg nqaij. Tsis tas li ntawd, muaj ib qho impulse tshwm sim ntawm ib kawg ntawm lub paj hlwb los ntawm kev khi ntawm neurotransmitters rau cov receptors.
Feem ntau, strychnine yog tshuaj lom rau tib neeg hauv cov koob tshuaj siab thiab rau ntau yam tsiaj. Kev lom ntawm strychnine los ntawm kev nqus pa, nqos, lossis nqus los ntawm qhov muag lossis qhov ncauj tuaj yeem ua rau tuag taus. Txawm li cas los xij, tsis muaj cov tshuaj tiv thaiv tshwj xeeb rau cov tshuaj no. Tab sis peb tuaj yeem rov qab los ntawm kev raug mob nrog kev txhawb nqa kev kho mob thaum ntxov.
Qhov txawv ntawm Brucine thiab Strychnine yog dab tsi?
Brucine thiab strychnine yog ob hom alkaloids. Alkaloids muaj tsawg kawg ib nitrogen atom ib molecule, tab sis lawv yog cov organic tebchaw. Qhov sib txawv tseem ceeb ntawm brucine thiab strychnine yog tias brucine muaj tshuaj lom tsawg dua li strychnine.
Hauv qab no yog cov ntsiab lus ntawm qhov sib txawv ntawm brucine thiab strychnine hauv daim ntawv tabular.
Summary – Brucine vs Strychnine
Alkaloids yog ib pawg ntawm cov organic tebchaw uas muaj tsawg kawg yog ib qho nitrogen atom ib molecule. Qhov sib txawv tseem ceeb ntawm brucine thiab strychnine yog tias brucine muaj tshuaj lom tsawg dua li strychnine.
