Qhov sib txawv tseem ceeb ntawm G CSF thiab GM CSF yog tias G CSF yog ib qho kev txhawb zog uas txhawb nqa kev loj hlob ntawm neutrophil thiab kev loj hlob thaum GM CSF yog ib qho kev txhawb zog uas qhia tau hais tias muaj kev cuam tshuam ntau dua rau ntau lub xov tooj ntawm tes, tshwj xeeb tshaj yog rau macrophages thiab eosinophils.
G CSF lossis granulocyte colony-stimulating factor thiab GM CSF los yog granulocyte-macrophage colony-stimulating factor yog ob yam kev loj hlob hematopoietic. Lawv yog cov tshuaj tiv thaiv kab mob thiab. Kev loj hlob ntawm molecularly cloned G CSF thiab GM CSF tau nce kev nyab xeeb thiab kev ua tau zoo ntawm kev siv tshuaj kho mob hnyav thiab kev kho hluav taws xob txhawm rau txhawm rau thim rov qab kev puas tsuaj rau cov pob txha ua haujlwm. Nws txo cov kab mob, los ntshav thiab txo kev mus pw hauv tsev kho mob. Ntxiv mus, cov tshuaj no yog ib qho tseem ceeb rau kev hloov cov cell hematopoietic.
G CSF yog dab tsi?
Granulocyte colony-forming factor lossis G CSF yog cov protein uas tsim los ntawm lub cev. Nws yog qhov feem ntau siv molecularly cloned hematopoietic kev loj hlob yam. Cov noob uas sau rau G CSF muaj nyob rau hauv chromosome 17. G CSF txhawb cov pob txha pob txha thiaj li tsim tau ntau cov neutrophils, uas yog cov kab mob sib tua cov qe ntshav dawb. Hauv lwm lo lus, G CSF pab cov pob txha pob txha ua kom cov qe ntshav dawb ntau dua los tawm tsam antigens. Nws yog siv los kho cov neeg mob uas muaj mob qog noj ntshav thiab neutropenia. Nws kuj tseem siv tau rau cov neeg mob uas tau txais kev hloov pauv autologous qia cell.
Figure 01: G CSF
Filgrastim thiab pegfilgrastim, thiab lawv cov biosimilars yog cov piv txwv ntawm G CSF. Filgrastim yog ib qho protein ua hauv E coli. Yog li ntawd, nws yog ib tug recombinant tib neeg G CSF. Zoo ib yam li filgrastim, lenograstim yog lwm tus neeg recombinant G CSF.
GM CSF yog dab tsi?
Granulocyte macrophage colony-stimulating factor lossis GM CSF yog ib qho kev loj hlob ntawm hematopoietic uas txhawb nqa kev loj hlob ntawm granulocytes thiab macrophages los ntawm cov pob txha pob txha ua ntej. Nws yog glycoprotein uas tsim los ntawm macrophages, T cells, mast cells, ntuj killer cells, endothelial cells thiab fibroblasts. Cov receptors ntawm GM CSF tau nthuav tawm dav dua G CSF receptors.
Daim duab 02: GM CSF
GM CSF qhia txog ntau yam kev ua ub no ntawm biologic, suav nrog tshuaj tua kab mob, tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob. GM CSF muaj kev cuam tshuam ntau dua rau ntau cov kab mob ntawm tes, tshwj xeeb tshaj yog ntawm macrophages thiab eosinophils. Sargramostim yog ib qho molecularly cloned GM CSF thiab glycosylated protein ua nyob rau hauv S. cerevisiae. Clinically, GM CSF yog siv rau hauv kev kho mob rau neutropenia hauv cov neeg mob qog noj ntshav uas tau txais kev kho mob, cov neeg mob AIDS thaum kho, thiab cov neeg mob tom qab hloov cov pob txha pob txha.
Dab tsi yog qhov zoo sib xws ntawm G CSF thiab GM CSF?
- G CSF thiab GM CSF yog ob hom kev loj hlob ntawm hematopoietic yam.
- Lawv yog pawg neeg txhawb nqa.
- YLawv yog glycoproteins.
- G CSF thiab GM CSF tau muab tso rau hauv lub cev lossis subcutaneously.
- Ob leeg muaj muag hauv daim ntawv rov ua dua rau kev siv tshuaj kho mob.
- Qhov chaw ntawm ob yam yog cov hlwb endothelial, monocytes, macrophages, thiab fibroblasts.
- Ob cov tshuaj ua rau mob, luv luv leukopenia tom qab txhaj tshuaj,
Qhov txawv ntawm G CSF thiab GM CSF yog dab tsi?
Qhov sib txawv tseem ceeb ntawm G CSF thiab GM CSF yog tias G CSF yog ib qho kev txhawb zog uas txhawb nqa kev loj hlob ntawm neutrophil thiab kev loj hlob thaum GM CSF yog ib qho kev txhawb zog uas qhia tau hais tias muaj kev cuam tshuam ntau dua rau ntau lub xov tooj ntawm tes, tshwj xeeb tshaj yog rau macrophages thiab eosinophils. Ntxiv mus, G-CSFR tau qhia feem ntau ntawm cov neutrophils thiab cov pob txha pob txha precursor hlwb, thaum GM-CSFR tau nthuav dav ntau dua li G-CSFR.
Cov ntaub ntawv hauv qab no qhia ntau qhov sib txawv ntawm G CSF thiab GM CSF hauv daim ntawv teev npe.
Summary – G CSF vs GM CSF
Ob leeg G CSF thiab GM CSF yog cov koom haum txhawb nqa uas yog qhov tseem ceeb ntawm hematopoietic kev loj hlob thiab kev tiv thaiv kab mob. G CSF yog glycoprotein uas txhawb cov pob txha pob txha los tsim cov qe ntshav dawb ntau dua los tiv thaiv kab mob. Tshwj xeeb tshaj yog, G CSF txhawb nqa neutrophil proliferation thiab maturation. GM CSF yog glycoprotein uas txhawb kev loj hlob ntawm granulocytes thiab macrophages los ntawm cov pob txha pob txha ua ntej cov hlwb. Tsis zoo li G CSF, GM CSF cuam tshuam ntau hom hlwb. Ntxiv mus, GM CSF receptors tau nthuav dav ntau dua li G CSF receptors. Tsis tas li ntawd, GM CSF muaj ntau yam kev ua haujlwm biologic ntau dua li G CSF. Txawm li cas los xij, ob qho tib si txhim kho cov tshuaj tua kab mob ntawm cov neutrophils paub tab. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm G CSF thiab GM CSF.
