Qhov txawv ntawm baricitinib tofacitinib thiab upadacitinib yog baricitinib yog ib qho inhibitor ntawm Jak1 thiab Jak2 thaum tofacitinib yog ib qho inhibitor ntawm Jak1 thiab Jak3 thiab upadacitinib yog xaiv inhibitor ntawm Jak1.
YJanus kinase lossis JAK yog tsev neeg ntawm cytoplasmic non-receptor tyrosine kinase proteins. Lawv cuam tshuam nrog cytokine receptors thiab qhib cov tswv cuab ntawm cov teeb liab transducer thiab activator ntawm transcription (STAT) tsev neeg ntawm cov ntaub ntawv transcription. Muaj cov tshuaj Janus kinase inhibitors. Tofacitinib, baricitinib, thiab upadacitinib yog peb hom tshiab xaiv qhov ncauj Janus activated kinase inhibitors hauv rheumatoid mob caj dab (RA).
RA yog ib tus kab mob autoimmune ntev uas tshwm sim los ntawm kev sib koom ua ke tsis tu ncua thiab nthuav tawm cov kab mob ntxiv cuam tshuam rau ntau lwm lub cev. Cytokines yog cov tsav tsheb tseem ceeb ntawm kev mob hauv RA. JAKs kho cov kev taw qhia hauv qab ntawm ntau yam cytokines thiab kev loj hlob yam cuam tshuam nrog kev mob autoimmune. Jak inhibitors tau pom zoo rau kev kho mob ntawm RA. Jak inhibitors xaiv inhibit jak isoforms uas yog jak1, jak2, jak3 thiab tyk2. Tofacitinib inhibits Jak1 thiab Jak3 thaum baricitinib inhibits Jak1 thiab Jak2. Upadacitinib selectively inhibits Jak1.
Baricitinib yog dab tsi?
Baricitinib (hom npe Olumiant) yog tshuaj kho mob rheumatoid mob caj dab (RA) rau cov neeg laus. Nws ua raws li inhibitor ntawm janus kinase (JAK), thaiv cov subtypes JAK1 thiab JAK2. Cov tshuaj no cuam tshuam nrog cov txheej txheem inflammatory hauv lub cev tiv thaiv kab mob uas ua rau cov tsos mob ntawm RA. Baricitinib yog ib qho tshuaj pom zoo rau nruab nrab mus rau hnyav RA hauv cov neeg laus dua 60 lub teb chaws. Baricitinib los ua ntsiav tshuaj.
Daim duab 01: Baricitinib
Kev kho mob ntev nrog baricitinib zoo hauv kev kho RA. Ua ntej pib cov kev kho mob rau RA siv baricitinib, nws tseem ceeb heev kom paub meej tias koj puas tau kis tus kab mob ntsws (TB) lossis kab mob siab. Ua ntej pib baricitinib, nws yog ib qho tsim nyog yuav tsum tau kawm txog kev kho mob latent (asymptomatic) TB. Thaum xav txog kab mob siab, baricitinib tuaj yeem ua rau muaj kev pheej hmoo ntawm kev rov ua kom tus kab mob siab.
Tofacitinib yog dab tsi?
Tofacitinib (hom npe Xeljanz) yog lwm Jak inhibitor uas yog siv los kho mob rheumatoid mob caj dab (RA), psoriatic mob caj dab, thiab ulcerative colitis. Nws kuj tseem siv los kho qee yam kab mob hauv plab (ulcerative colitis). Nws pab txo cov tsos mob ntawm tus kab mob ulcerative colitis xws li raws plab, qhov quav los ntshav, thiab mob plab. Nws yog ib qho me me molecule uas inhibits jak isoforms 1 (jak1) thiab 3 (jak3).
Daim duab 02: Tofacitinib
Yeej, tofacitinib cuam tshuam nrog JAK-STAT teeb liab txoj hauv kev los ntawm kev thaiv lub cev tsim cov enzymes. Tofacitinib muaj nyob rau hauv cov ntsiav tshuaj. Nws yog noj ntawm qhov ncauj. Zoo ib yam li baricitinib, tofacitinib yog kev kho mob mus sij hawm ntev.
Upadacitinib yog dab tsi?
Upadacitinib (hom npe Rinvoq) yog ib qho tshuaj tiv thaiv jak zoo ib yam li baricitinib thiab tofacitinib. Nws yog ib hom tshuaj thib ob uas inhibits Jak1 xaiv los ntawm kev thaiv cov enzymes ua rau mob. Yog li ntawd, nws yog siv los kho mob nruab nrab mus rau hnyav rheumatoid mob caj dab rau cov neeg laus. Nws tuaj yeem siv ua ke nrog methotrexate thiab. Thaum piv nrog baricitinib thiab tofacitinib, upadacitinib muaj subtype selectivity.
Daim duab 03: Upadacitinib
Upadacitinib tuaj yeem ua rau muaj ntau yam tshwm sim, suav nrog cov kab mob ua pa sab saud xws li mob khaub thuas thiab kab mob hauv qhov ntswg, thiab lwm yam, xeev siab, hnoos, thiab ua npaws. Sib nrug los ntawm cov kev mob tshwm sim no, upadacitinib tuaj yeem ua rau muaj kev phiv loj heev, suav nrog mob ntsws, cellulitis thiab tuberculosis.
Dab tsi yog qhov zoo sib xws ntawm Baricitinib Tofacitinib thiab Upadacitinib?
- Baricitinib, tofacitinib thiab upadacitinib yog hom Janus kinase (JAK) inhibitor tshuaj lossis tshuaj.
- Peb yog cov tshuaj pom zoo.
- Ob leeg txhim kho RA tswj.
- Lawv hais lus.
Qhov txawv ntawm Baricitinib Tofacitinib thiab Upadacitinib yog dab tsi?
Baricitinib yog Jak inhibitor uas inhibits Jak isoforms 1 thiab 2 thaum Tofacitinib yog thawj tiam jak inhibitor uas inhibits subtypes Jak1 thiab Jak3. Upadacitinib yog ib tiam thib ob ntawm Janus kinase inhibitor uas yog xaiv rau Jak1. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm baricitinib tofacitinib thiab upadacitinib. Olumiant yog lub npe ntawm baricitinib thaum Xeljanz thiab Rinvoq yog cov npe ntawm tofacitinib thiab upadacitinib, feem.
Cov hauv qab no infographic tabulates ib sab ntau qhov sib txawv ntawm baricitinib tofacitinib thiab upadacitinib.
Summary – Baricitinib vs Tofacitinib vs Upadacitinib
Baricitinib, tofacitinib thiab upadacitinib yog qhov ncauj Jak inhibitors. Lawv yog cov tshuaj pom zoo siv los kho cov neeg laus nrog mob me me mus rau mob rheumatoid mob caj dab hnyav. Baricitinib inhibits Jak1 thiab 2 thaum tofacitinib inhibits Jak1 thiab 3. Upadacitinib selectively inhibits Jak1. Lawv lub npe yog Olumiant, Xeljanz thiab Rinvoq, raws li. Yog li, qhov no qhia txog qhov sib txawv ntawm baricitinib tofacitinib thiab upadacitinib.
