Qhov sib txawv tseem ceeb ntawm JAK1 JAK2 thiab JAK3 yog JAK1 yog qhov tseem ceeb rau kev taw qhia ntawm qee yam I thiab hom II cytokines thaum JAK2 yog qhov tseem ceeb rau kev taw qhia ntawm hom II cytokine receptor tsev neeg, GM-CSF receptor tsev neeg, gp130 receptor tsev neeg, thiab ib leeg-chain receptors. Lub caij no, JAK3 yog qhov tseem ceeb rau kev taw qhia ntawm hom I receptors uas siv cov saw gamma (γc).
YJanus Kinase (JAK los yog Jaks) yog ib tsev neeg ntawm intracellular non-receptor protein tyrosine kinases. Lawv yog cov sib piv loj cov proteins uas muaj ntau dua 1000 amino acids. Jaks yog ib qho tseem ceeb rau kev loj hlob ntawm tes, ciaj sia taus, kev loj hlob, thiab kev sib txawv ntawm ntau lub hlwb tab sis tseem ceeb heev rau lub cev tiv thaiv kab mob thiab cov hlwb hematopoietic. Muaj plaub tus tswv cuab hauv tsev neeg Jak li Janus kinase 1 (Jak1), Janus kinase 2 (Jak2), Janus kinase 3 (Jak3), thiab Tyrosine kinase 2 (Tyk2). Jak1, Jak2, thiab Tyk2 tau nthuav tawm ubiquitously hauv cov tsiaj nyeg thaum Jak3 feem ntau qhia hauv cov hlwb hematopoietic. Tofacitinib yog ib qho kev xaiv inhibitor rau JAK1 rau JAK3, thaum baricitinib yog xaiv rau JAK1 thiab JAK2.
JAK1 yog dab tsi?
JAK1 yog ib tug ntawm plaub tug tswv cuab ntawm Jak tsev neeg. Nws yog tib neeg tyrosine kinase protein uas yog qhov tseem ceeb rau qee yam I thiab hom II cytokines. Ntxiv mus, Jak1 yog ib qho tseem ceeb rau kev hloov lub teeb liab los ntawm hom I (IFN-α / β) thiab hom II (IFN-γ) interferons, thiab cov tswv cuab ntawm tsev neeg IL-10 ntawm hom II cytokine receptor. Ib yam li ntawd, Jak1 ua lub luag haujlwm tseem ceeb hauv kev pib cov lus teb rau ntau tsev neeg cytokine receptor loj. Tsis muaj Jak1 ua rau nas tuag.
Daim duab 01: JAK1
JAK2 yog dab tsi?
Janus kinase 2 lossis JAK2 yog lwm tus tswvcuab ntawm Jak tsev neeg uas yog cov tsis muaj tyrosine kinase. Gene JAK2 codes rau JAK2 protein. Jak2 mediates teeb liab los ntawm hom II cytokine receptor tsev neeg, GM-CSF receptor tsev neeg, gp130 receptor tsev neeg, thiab ib leeg-chain receptors. JAK2 tsis muaj Src homology binding domains (SH2/SH3). Tab sis nws muaj txog li xya JAK homology domains (JH1-JH7). Ob yam no yog pab kom paub qhov txawv ntawm JAK2 los ntawm peb tus tswv cuab.
Daim duab 02: JAK2
Poob JAK2 ua rau nas. Kev hloov pauv hauv JAK2 noob yog cuam tshuam nrog ntau yam kab mob xws li polycythemia vera, qhov tseem ceeb thrombocythemia, thiab myelofibrosis thiab lwm yam kab mob myeloproliferative.
JAK3 yog dab tsi?
KAK3 yog tus tswv cuab thib peb ntawm Jak tsev neeg thiab tau sau los ntawm JAK3 noob. JAK3 yog qhov tseem ceeb rau kev taw qhia hom I receptors uas siv cov saw gamma (γc). JAK3 noob yog qhia nyob rau hauv hematopoietic thiab epithelial hlwb thiab tsim JAK3 proteins. Jak3 deficiency ua rau lymphopenia hnyav rau nas thiab tib neeg.
Daim duab 03: JAK3
JAK3 lub luag haujlwm tsuas yog txwv rau cov lymphocytes. Li no, JAK3 inhibitors yog qhov txaus nyiam raws li kev kho mob rau ntau hom kab mob autoimmune. Kev hloov pauv tau tshwm sim hauv JAK3 noob ua rau muaj kev tiv thaiv kab mob sib kis loj thiab mob qog ntshav ntshav.
Dab tsi yog qhov zoo sib xws ntawm JAK1 JAK2 thiab JAK3?
- JAK1, JAK2 thiab JAK3 yog JAK isoforms.
- Lawv yog intracellular non-receptor protein tyrosine kinases.
- Qhov tseeb, lawv yog cov protein ntau.
- Jaks tau txais txiaj ntsig zoo, thiab JAK isoforms tsis rov ua dua.
- Kev poob ntawm JAK1, JAK2 thiab JAK3 ua rau nas tuag.
- JAK inhibitors yog cov tshuaj siv los tiv thaiv kev ua haujlwm ntawm JAK1, JAK2 thiab JAK3.
- Kev hloov pauv hauv cov noob caj noob ces rau JAK1, JAK2 thiab JAK3 ua rau muaj kev cuam tshuam, suav nrog ntau yam pob txha pob txha, mob qog ntshav ntshav, thiab kab mob autoimmune.
Qhov txawv ntawm JAK1 JAK2 thiab JAK3 yog dab tsi?
JAK1 yog ib tug tswv cuab ntawm Jak tsev neeg uas yog qhov tseem ceeb rau kev taw qhia ntawm qee yam kuv thiab hom II cytokines. Whereas, JAK2 yog ib tug tswv cuab ntawm Jak tsev neeg uas yog qhov tseem ceeb rau kev taw qhia ntawm hom II cytokine receptor tsev neeg, GM-CSF receptor tsev neeg, gp130 receptor tsev neeg, thiab ib leeg saw receptors. Lub caij no, JAK3 yog tus tswv cuab thib peb ntawm Jak tsev neeg uas yog qhov tseem ceeb rau kev taw qhia ntawm hom kuv receptors uas siv cov saw gamma (γc). Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm JAK1 JAK2 thiab JAK3. JAK1 noob codes rau Jak1 thaum JAK2 noob codes rau Jak2 thiab JAK3 noob codes rau Jak3.
Cov hauv qab no infographic tabulates ntau qhov sib txawv ntawm JAK1 JAK2 thiab JAK3.
Summary – JAK1 JAK2 vs JAK3
Jak proteins txuas cov cytokine signaling los ntawm cov membrane receptors rau cov teeb liab transducers thiab activators ntawm transcription (STAT) transcription yam. Yog li, Jaks yog cov protein tseem ceeb hauv cov teeb liab hloov pauv pib los ntawm ntau yam ntawm cov membrane receptors, tshwj xeeb tshaj yog IFN alpha, beta thiab gamma receptors. Jaks tau kawm ntau heev vim lawv lub luag haujlwm tseem ceeb hauv kev mob qog noj ntshav thiab mob. JAK tsev neeg nyob rau hauv cov tsiaj muaj plaub isoforms li JAK1, JAK2, JAK3, thiab TYK2. Qhov sib txawv tseem ceeb ntawm JAK1 JAK2 thiab JAK3 yog JAK1 yog qhov tseem ceeb rau kev taw qhia ntawm qee yam I thiab hom II cytokines thaum JAK2 yog qhov tseem ceeb rau kev taw qhia ntawm hom II cytokine receptor tsev neeg, GM-CSF receptor tsev neeg, gp130 receptor tsev neeg, thiab ib leeg-chain. receptors thiab JAK3 yog qhov tseem ceeb rau kev taw qhia ntawm hom I receptors uas siv cov saw gamma (γc).
