Qhov sib txawv tseem ceeb ntawm Robertsonian translocation thiab isochromosome yog Robertsonian translocation yog ib daim ntawv ntawm chromosomal translocation uas koom nrog fusion ntawm tag nrho cov caj npab ntev ntawm ob acrocentric chromosomes thaum isochromosome yog ib qho txawv txav chromosome uas muaj ob txhais caj npab zoo tib yam vim kev sib tw. ntawm ib sab caj npab thiab tshem tawm ntawm lwm tus.
Robertsonian translocation thiab isochromosome yog ob qho kev txawv txav ntawm chromosomal. Hauv Robertsonian translocation, qee hom chromosomes txuas rau ib leeg. Nws yog hom kev hloov pauv ntau tshaj plaws hauv tib neeg. Isochromosome, ntawm qhov tod tes, yog ib qho txawv txav chromosome uas muaj ob txhais caj npab zoo ib yam. Cov caj npab ntawm isochromosome yog daim iav duab ntawm ib leeg.
Robertsonian Translocation yog dab tsi?
Robertsonian translocation yog hom chromosome hloov pauv ntau tshaj plaws paub hauv tib neeg. Nws yog ib daim ntawv ntawm chromosomal translocation uas tshwm sim los ntawm fusion ntawm tag nrho cov caj npab ntev ntawm ob acrocentric chromosomes. Qhov no ua rau ib qho loj metacentric chromosome thiab ib qho me me. Kwv yees li 1 ntawm 1000 tus neeg tau yug los nrog qhov kev hloov kho chromosome. Feem ntau, acrocentric chromosomes 3, 14, 15, 21 thiab 22 hauv tib neeg tau txais Robertsonian translocation. Feem ntau cov qauv ntawm Robertsonian translocations yog nruab nrab ntawm chromosomes 13 thiab 14, ntawm 13 thiab 21, thiab ntawm 21 thiab 22 hauv tib neeg. Txawm hais tias nws yog chromosomal txawv txav, nyob rau hauv daim ntawv sib npaug thiab tsis ua rau muaj teeb meem kev noj qab haus huv.
Daim duab 01: Robertsonian Translocation
Txawm li cas los xij, hauv daim ntawv tsis sib npaug, nws tuaj yeem ua rau muaj kab mob caj ces xws li Down syndrome (trisomy 21) thiab Patau syndrome (trisomy 13). Tsis tas li ntawd, nws tuaj yeem ua rau muaj qhov tshwm sim ntawm kev xeeb tub thiab kev pheej hmoo ntawm caj ces tsis sib xws ntawm lawv cov xeeb ntxwv.
Isochromosome yog dab tsi?
Isochromosome yog ib qho txawv txav chromosome uas muaj ob daim ntawv ntawm ob sab caj npab ntev lossis caj npab luv. Cov caj npab ntawm isochromosome yog daim iav duab ntawm ib leeg. Nws yog ib qho kev tsis sib haum xeeb ntawm cov qauv.
Daim duab 02: Isochromosome
Isochromosomes yog tsim los ntawm kev sib npaug ntawm ib sab caj npab thiab poob ntawm lwm caj npab. Tom qab ntawd cov hlwb yuav tsuas muaj ib daim ntawv theej ntawm cov khoom siv caj ces hauv caj npab tam sim no nyob rau hauv ib txwm muaj tswv cuab ntawm homologous khub. Hauv cov lus yooj yooj yim, cov hlwb uas muaj isochromosome muaj trisomy rau caj npab uas tau duplicated thiab monosomy rau caj npab uas raug tshem tawm. Zoo ib yam li Robertsonian translocation, isochromosome tsim yog ib tug nquag chromosomal aberration nyob rau hauv tib neeg. Turner syndrome thiab Neoplasia yog ob qhov tshwm sim ntawm isochromosome tsim.
Dab tsi zoo sib xws ntawm Robertsonian Translocation thiab Isochromosome?
- Ob qho tib si Robertsonian kev hloov pauv thiab kev tsim isochromosome muaj nyob hauv acrocentric chromosomes.
- Nyob rau hauv ob txoj kev, koom nrog chromosomes tawg ntawm lawv cov centromeres.
Qhov txawv ntawm Robertsonian Translocation thiab Isochromosome yog dab tsi?
Robertsonian translocation yog ib daim ntawv ntawm chromosomal translocation nyob rau hauv uas ob tug acrocentric chromosomes fuse ntawm lawv centric kawg thaum isochromosomes yog chromosomes muaj li ntawm daim iav dluab ntawm ib sab caj npab ntawm chromosome. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm Robertsonian translocation thiab isochromosome. Lub fusion ntawm tag nrho cov caj npab ntev ntawm ob acrocentric chromosomes tshwm sim nyob rau hauv Robertsonian translocation thaum duplication ntawm ib sab caj npab thiab deletion ntawm lwm yam yuav siv qhov chaw nyob rau hauv isochromosome tsim.
Ntxiv mus, lwm qhov sib txawv ntawm Robertsonian translocation thiab isochromosome yog lawv qhov tshwm sim. Trisomy 13 (Patau syndrome) thiab trisomy 21 (Down syndrome) yog ob qhov tshwm sim ntawm Robertsonian translocation thaum Turner syndrome thiab Neoplasia yog ob qhov tshwm sim ntawm isochromosome tsim.
Hauv qab infographic tabulates qhov sib txawv ntawm Robertsonian translocation thiab isochromosome.
Summary – Robertsonian Translocation vs Isochromosome
Hauv Robertsonian translocation, ob lub acrocentric chromosomes tawg ntawm lawv cov centromeres thiab caj npab ntev fuse los ua ib qho, loj chromosome nrog ib lub centromere. Hauv kev tsim isochromosome, centromeres ntawm chromosomes faib transversely thiab kev sib koom ua ke ntawm ob txhais caj npab zoo ib yam tshwm sim. Yog li ntawd, isochromosome muaj ob txhais caj npab zoo tib yam uas yog daim iav duab ntawm ib leeg. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm Robertsonian translocation thiab isochromosome.
