Qhov sib txawv tseem ceeb ntawm L-phenylalanine thiab DL-phenylalanine yog L-phenylalanine yog L isomer ntawm phenylalanine whereas DL-phenylalanine yog racemic sib tov ntawm D thiab L isomers phenylalanine.
Phenylalanine yog ib qho tseem ceeb alpha-amino acid. Nws muaj cov tshuaj formula C9H11NO2. Thaum xav txog cov qauv ntawm phenylalanine molecule, nws muaj ib lub nplhaib benzene (phenyl pawg) hloov nrog methyl derivative ntawm alanine pawg. Yog li, qhov no yog vim li cas rau npe nws li phenyl-alanine.
YL-Phenylalanine yog dab tsi?
L-phenylalanine yog L-isomer ntawm phenylalanine. Phenylalanine yog alpha-amino acid uas muaj lub nplhaib benzene hloov mus rau methyl derivative ntawm alanine pawg. Cov amino acid no yog ib qho nruab nrab thiab tsis muaj polar compound vim nws yog inert thiab hydrophobic nyob rau hauv nws benzyl sab saw. L isomer ntawm phenylalanine yog qhov tseem ceeb hauv kev tsim cov proteins uas biochemically coded los ntawm DNA.
Daim duab 01: Cov qauv ntawm L-phenylalanine
L-phenylalanine yog cov isomer nquag thiab ruaj khov nyob rau hauv qhov xwm txheej. Lawm, peb tuaj yeem pom cov amino acid no hauv cov mis nyuj ntawm cov tsiaj. Tsis tas li ntawd, nws muaj txiaj ntsig zoo hauv kev tsim cov khoom noj thiab dej haus kom muag raws li cov khoom noj khoom haus vim nws cov khoom siv tshuaj lom neeg thiab cov tshuaj tiv thaiv kev ntxhov siab. Cov peev txheej ntawm L-phenylalanine muaj xws li qe, nqaij qaib, daim siab, nqaij nyuj, mis nyuj, thiab taum pauv.
Biologically, L-phenylalanine tau hloov mus rau L-tyrosine. L-tyrosine kuj yog ib qho amino acid uas yog coded los ntawm DNA. Tsis tas li ntawd, L-tyrosine hloov mus rau L-DOPA, uas yog lub luag haujlwm rau kev tsim cov dopamine, adrenaline thiab noradrenaline. Ntxiv mus, nyob rau hauv cov nroj tsuag, L-phenylalanine yog ib qho tseem ceeb raws li qhov pib compound rau synthesis ntawm flavonoids. Feem ntau, L-phenylalanine yog tsim los rau kev kho mob, pub, thiab kev siv khoom noj khoom haus. Qhov ntau ntawm cov khoom no tau nce ntau siv E.coli.
Dab tsi yog DL-Phenylalanine
DL-phenylalanine yog ib hom kev sib xyaw ntawm D thiab L isomers ntawm phenylalanine. Ntawm ob lub isomers no, L-phenylalanine yog cov isomer uas muaj thiab ruaj khov thaum D-phenylalanine tsis tshua muaj tshwm sim vim qhov tsis muaj zog. Txawm li cas los xij, peb tuaj yeem tsim D-phenylalanine molecule ntawm cov pa organic synthesis. Tab sis cov tshuaj tiv thaiv no muab cov isomer ua ib qho enantiomer los yog ib hom kev sib xyaw uas peb tuaj yeem hu ua DL-phenylalanine. Qhov sib xyaw racemic no tsis tuaj yeem koom nrog hauv cov protein biosynthesis. Hom kev sib xyaw no kuj tshwm sim hauv cov lej hauv cov proteins.
Daim duab 02: Biosynthesis ntawm Dopamine pib los ntawm Phenylalanine
Peb tuaj yeem pom DL-phenylalanine sib xyaw hauv khw ua khoom noj khoom haus ntxiv. Cov tshuaj no tseem ceeb heev vim nws cov tshuaj analgesic thiab antidepressant zog. Cov khoom no tshwm sim vim muaj qhov cuam tshuam ntawm enkephalin degradation los ntawm D-phenylalanine.
Qhov txawv ntawm L-phenylalanine thiab DL-phenylalanine yog dab tsi?
Phenylalanine yog ib qho tseem ceeb alpha amino acid uas tshwm sim hauv ob isomers li L isomer thiab D isomer. Qhov sib txawv tseem ceeb ntawm L-phenylalanine thiab DL-phenylalanine yog tias L-phenylalanine yog L isomer ntawm phenylalanine thaum DL-phenylalanine yog racemic sib xyaw ntawm D thiab L isomers phenylalanine.
Ntxiv mus, L-phenylalanine yog ib txwm muaj thiab ruaj khov nyob rau hauv cov xwm txheej thaum DL-phenylalanine tuaj yeem pom hauv cov lej. L-phenylalanine biologically hloov mus rau hauv L-tyrosine rau tsim dopamine, tuaj yeem dhau los ntawm cov hlab ntsha hauv hlwb, tus antagonist, tuaj yeem cuam tshuam cov neurotransmitters, thiab lwm yam. los ntawm cov ntshav-hlwb barrier thiab yog ib qho tseem ceeb raws li kev noj haus ntxiv.
Hauv qab infographic tabulates hauv kev nthuav dav qhov sib txawv ntawm L-phenylalanine thiab DL-phenylalanine.
Summary – L-phenylalanine vs DL-phenylalanine
Phenylalanine yog ib qho tseem ceeb alpha-amino acid uas tshwm sim hauv ob isomers li L isomer thiab D isomer. Qhov sib txawv tseem ceeb ntawm L-phenylalanine thiab DL-phenylalanine yog tias L-phenylalanine yog L isomer ntawm phenylalanine whereas DL-phenylalanine yog racemic sib xyaw ntawm D thiab L isomers phenylalanine.
