Qhov txawv ntawm V Hom thiab F Hom ATPase

2024 Tus sau: Alex Aldridge | [email protected]. Kawg hloov kho: 2023-12-17 13:40

Qhov sib txawv tseem ceeb ntawm V hom thiab F hom ATPase yog V hom ATPase ua haujlwm raws li ATP-tsav ion twj thaum F hom ATPase ua haujlwm li ATP synthase hauv hlwb.

ATPase yog ib lo lus uas hais txog cov enzymes uas muaj peev xwm hydrolyze ATP. Feem ntau, ATPases decompose ATP thiab lub zog tso tawm thaum lub sijhawm cov tshuaj tiv thaiv yog siv los ua haujlwm vim ATP yog lub zog txiaj uas muab lub zog rau tag nrho cov txheej txheem ntawm tes. ATP kev puas tsuaj xav tau ATPases. Yog li, ATPases txo qis lub zog ua haujlwm ntawm ATP hydrolysis. Muaj plaub yam tseem ceeb ntawm ATPases li F-ATPases, V-ATPases, A-ATPases thiab P-ATPases. V hom ATPases feem ntau pom muaj nyob hauv eukaryotic cell vacuoles. Nyob rau hauv sib piv, F hom ATPases muaj nyob rau hauv cov kab mob plasma membranes, mitochondria puab membrane thiab chloroplasts. Lawv catalyze hydrolysis lossis synthesis ntawm ATP coupling nrog H⁺ (los yog Na^{+) thauj hla ib daim nyias nyias.}

V Type ATPase yog dab tsi?

Vacuolar type H⁺ ATPase lossis V hom ATPase yog ib qho ntawm plaub hom ATPases. Nws yog ib tug membrane protein complex uas muaj ib tug loj ntawm 1 MDa. Nws muaj ob lub ntsiab tseem ceeb xws li V₀ sau thiab V₁ sau, muaj tsawg kawg kaum peb subunits. Nws kuj muaj rotary motors. V₁ domain yog lub luag haujlwm rau ATP hydrolysis thaum V_{0 domain yog lub luag haujlwm rau kev hloov pauv proton.}

Daim duab 01: V Hom ATPase

V hom ATPases muaj feem ntau hauv eukaryotic cell vacuoles. Ntxiv mus, lawv muaj nyob rau hauv Golgi apparatus, endosomes thiab lysosomes. Lawv kuj muaj nyob rau hauv cov kab mob. Cov enzyme no hydrolyzes ATP thiab siv lub zog tso tawm rau kev lag luam protein, kev thauj mus los ntawm cov metabolites, cov tshuaj neurotransmitter tso tawm, kev tswj cov khib nyiab thiab cov protein degradation, thiab lwm yam. Tsis tas li ntawd, V hom ATPases acidify ntau cov cellular organelles.

F Type ATPase yog dab tsi?

F hom ATPase lossis ATP synthase yog lwm cov enzyme pom muaj nyob rau hauv cov kab mob plasma membranes, mitochondria inner membrane thiab chloroplasts. Nws yog thawj tus tsim khoom ntawm ATP. Nws siv proton gradient tsim los ntawm oxidative phosphorylation hauv mitochondria los tsim ATP. Ntxiv mus, nws siv photophosphorylation ntawm photosynthesis hauv chloroplasts los tsim ATP.

Daim duab 02: F Hom ATPase

F hom ATPase yog ib qho kev sib koom ua ke uas muaj ob lub npe ua F₀ thiab F₁ F₀ domain txuas mus rau mitochondrial membrane, thaum F₁ domain txuas mus rau hauv lub lumen. F₁ tus sau npe yog lub luag haujlwm rau ATP kev hloov pauv thaum F_{0 tus sau npe yog lub luag haujlwm rau ion translocation.}

Dab tsi zoo sib xws ntawm V Hom thiab F Hom ATPase?

• V hom thiab F hom ATPases yog ob hom ATPases uas yog cov enzymes thiab qhov tseem ceeb cellular zog converters.
• Lawv muaj nyob hauv eukaryotes thiab kab mob.a
• Ob leeg muaj cov motors teb.
• Lawv yog multi-subunit complexes.
• Ob leeg yog tsim los ntawm ob lub npe raws li kev sib xyaw ua ke thiab cov txheej membrane complex.

Qhov txawv ntawm V Hom thiab F Hom ATPase yog dab tsi?

Vacuolar type H^{+ ATPase lossis V hom ATPase yog ib qho enzyme uas tsim lub zog los ntawm ATP hydrolysis los thauj cov protons hla intracellular thiab plasma membranes ntawm eukaryotic hlwb. Hauv qhov sib piv, F hom ATPase yog ib qho enzyme uas ua haujlwm raws li cov enzyme tseem ceeb ntawm ATP synthesis. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm V hom thiab F hom ATPase. Tsis tas li ntawd, V-type ATPases muaj nyob rau hauv vacuoles ntawm eukaryotes thiab hauv cov kab mob thaum F-hom ATPases muaj nyob rau hauv eukaryotic mitochondria thiab chloroplasts nrog rau cov kab mob.}

Ntxiv mus, V hom ATPase hydrolyzes ATP thiab harness zog thauj proton hla intracellular thiab plasma membranes ntawm eukaryotic hlwb, thaum F hom ATPase tsim ATP ntawm oxidative phosphorylation thiab photophosphorylation. Yog li, qhov no yog qhov sib txawv ntawm V hom thiab F hom ATPase.

Hauv qab infographic muab cov ntsiab lus ntxiv ntawm qhov sib txawv ntawm V hom thiab F hom ATPase.

Summary – V Type vs F Type ATPase

V hom thiab F hom ATPases yog cov enzymes nyob rau hauv cytoplasmic daim nyias nyias ntawm cov kab mob thiab daim nyias nyias ntawm eukaryotic organelles, xws li mitochondria thiab chloroplasts. Ob leeg yog cov complexes muaj ntau tshaj 10 subunits sib sau ua ke rau hauv ob hom sib txawv. Ib tug sau yog ib tug catalytic domain koom nrog rau hauv lub zog hloov dua siab tshiab thaum lub lwm yam sector yog ib tug membrane domain koom tes nyob rau hauv proton translocation hla lub membrane. V hom ATPase hydrolyzes ATP thiab harness zog thauj protons hla intracellular thiab plasma daim nyias nyias ntawm eukaryotic hlwb. F hom ATPase tsim ATP ntawm oxidative phosphorylation thiab photophosphorylation. Yog li, qhov no qhia txog qhov sib txawv ntawm hom V thiab F hom ATPase.