Qhov sib txawv tseem ceeb ntawm Cope thiab Claisen rearrangement yog qhov reactant ntawm Cope rearrangement yog 1, 5-diene whereas lub reactant ntawm Claisen rearrangement yog ib qho allyl vinyl ether.
Ob leeg Cope rearrangement thiab Claisen rearrangement yog hom kev hloov pauv hloov pauv uas cuam tshuam nrog [3, 3]-sigmatropic rearrangements. Lub Cope rearrangement tau muaj npe tom qab Arthur C. Cope thaum Claisen rearrangement tau raug hu ua Rainer Ludwig Claisen. Muaj ntau ntau variations ntawm ob hom rearrangement. Muaj qee qhov kev hloov pauv ntawm Cope rearrangements uas suav nrog Aza-Cope rearrangements, Claisen rearrangement, thiab lwm yam. Qee qhov kev hloov pauv ntawm Claisen rearrangements muaj xws li aromatic Claisen rearrangement, bellus-Claisen rearrangement, Ireland-Claisen rearrangement, thiab lwm yam.
Kev Cob Qhia Rov Kho Dua yog dab tsi?
Kev kho dua tshiab yog ib hom kev hloov kho tshiab uas 1, 5-diene tau txais [3, 3]-sigmatropic rearrangements. Cov tshuaj tiv thaiv muaj npe tom qab Arthur C. Cope, uas tau tsim ib lub tswv yim rau cov tshuaj tiv thaiv no. Hom tshuaj tiv thaiv no tseem ceeb heev hauv cov organic synthesis cov tshuaj tiv thaiv. Muaj ib qho kev hloov pauv rau cov tshuaj tiv thaiv no. Lub xeev kev hloov pauv no dhau los ntawm lub nkoj zoo li lossis lub rooj zaum zoo li tus qauv. Piv txwv li, nthuav lub nplhaib cyclobutane rau hauv lub nplhaib 1, 5-cyclooctadiene. Qhov ntawd yog tsim ob lub cis ob daim ntawv cog lus. Cov tshuaj tiv thaiv yog raws li nram no:
Muaj qee qhov kev hloov pauv ntawm Cope rearrangements uas suav nrog Aza-Cope rearrangements, Claisen rearrangement, thiab lwm yam.
Claisen Rearrangement yog dab tsi?
Claisen rearrangement yog ib hom kev hloov kho cov tshuaj tiv thaiv uas allyl vinyl ethers hloov mus rau γ, δ-unsaturated carbonyl compounds. Ntxiv mus, nws yog lub npe hu ua Rainer Ludwig Claisen, uas nrhiav pom qhov tshwm sim no nyob rau hauv 1912. Qhov rearrangement tshwm sim los ntawm [3, 3]-sigmatropic rearrangements.
Cov tshuaj tiv thaiv no yog cov tshuaj tiv thaiv exothermic uas suav nrog cov nyiaj sib cais thiab rov ua dua. Nws yog cov tshuaj tiv thaiv stereospecific. Nws muaj thawj qhov kev txiav txim kinetics. Lub xeev hloov pauv ntawm Claisen rearrangement yog ib qho kev txiav txim siab heev. Tsis tas li ntawd, muaj cov tshuaj hnyav uas cuam tshuam rau cov tshuaj tiv thaiv. i.e. polar solvents accelerate cov tshuaj tiv thaiv. Muaj qee qhov kev hloov pauv ntawm Claisen rearrangements uas muaj xws li aromatic Claisen rearrangement, Bellus-Claisen rearrangement, Ireland-Claisen rearrangement, Johnson-Claisen rearrangement, Photo-Claisen rearrangement, thiab lwm yam.
Qhov txawv ntawm Kev Cope thiab Claisen Rearrangement yog dab tsi?
Ob leeg Cope rearrangement thiab Claisen rearrangement yog hom kev hloov pauv hloov pauv uas cuam tshuam nrog [3, 3]-sigmatropic rearrangements. Qhov sib txawv tseem ceeb ntawm Cope thiab Claisen rearrangement yog qhov reactant ntawm Cope rearrangement yog 1, 5-diene whereas lub reactant ntawm Claisen rearrangement yog ib qho allyl vinyl ether. Tsis tas li ntawd, cov khoom ntawm Cope rearrangement yog qhov sib txawv diene thaum cov khoom ntawm Claisen rearrangement yog γ, δ-unsaturated carbonyl compounds. Yog li, qhov no yog lwm qhov sib txawv ntawm Cope thiab Claisen rearrangement.
Ntxiv mus, Kev kho dua tshiab tau muaj npe tom qab Arthur C. Cope thaum Claisen rov kho dua tau raug hu ua Rainer Ludwig Claisen. Muaj qee qhov kev hloov pauv ntawm Cope rearrangements uas suav nrog Aza-Cope rearrangements, Claisen rearrangement, thiab lwm yam. Muaj qee qhov kev hloov pauv ntawm Claisen rearrangements uas suav nrog aromatic Claisen rearrangement, Bellus-Claisen rearrangement, Ireland-Claisen rearrangement, Johnson-Claisen rearrangement, Diam duab- Claisen rearrangement, thiab lwm yam.
Summary – Cope vs Claisen Rearrangement
Ob leeg Cope rearrangement thiab Claisen rearrangement yog hom kev hloov pauv hloov pauv uas cuam tshuam nrog [3, 3]-sigmatropic rearrangements. Qhov sib txawv tseem ceeb ntawm Cope thiab Claisen rearrangement yog qhov reactant ntawm Cope rearrangement yog 1, 5-diene whereas lub reactant ntawm Claisen rearrangement yog ib qho allyl vinyl ether. Ntxiv mus, cov khoom ntawm Cope rearrangement yog ib tug txawv diene thaum cov khoom ntawm Claisen rearrangement yog γ, δ-unsaturated carbonyl compounds.
