Qhov Tseem Ceeb Qhov txawv - Direct vs Indirect Bilirubin
Bilirubin yog cov khoom catabolic ntawm hemoglobin. Bilirubin muaj nyob rau hauv ob hom loj; conjugated thiab unconjugated bilirubin. Cov metabolism hauv bilirubin feem ntau tshwm sim hauv daim siab. Bilirubin nkag mus rau daim siab nyob rau hauv daim ntawv unconjugated thiab yog li hloov mus rau hauv daim ntawv conjugated tom qab ib co metabolic hloov dua siab tshiab. Lub conjugated bilirubin tseem hu ua direct bilirubin, thiab unconjugated bilirubin yog hu ua indirect bilirubin. Direct Bilirubin los yog conjugated daim ntawv ntawm bilirubin yog covalently hloov bilirubin uas tau nce solubility. Qhov no yog vim kev sib txuas lus nrog glucuronic acid, uas tshwm sim hauv daim siab. Indirect Bilirubin yog hom bilirubin uas tsis txuas lossis txuas rau lwm yam tshuaj lom neeg. Indirect bilirubin yog khi rau albumin, uas yog cov kab mob sib kis ntawm bilirubin. Qhov sib txawv tseem ceeb ntawm Direct thiab Indirect bilirubin yog tias ncaj qha bilirubin yog bilirubin uas yog conjugated nrog glucuronic acid thaum lub indirect bilirubin tsis conjugated rau daim siab thiab nws txuas mus rau lub carrier protein albumin..
Direct Bilirubin yog dab tsi?
Direct bilirubin yog covalently hloov indirect bilirubin. Qhov kev hloov kho covalent no yog ua los txo cov toxicity ntawm bilirubin thiab ua kom cov solubility ntawm bilirubin. Ua kom cov solubility ntawm bilirubin ua rau nws yooj yim rau cov txheej txheem excretion ntawm bilirubin. Kev sib txuas ntawm bilirubin tshwm sim nrog glucuronic acid raws li hauv qab no. UDP glucose yog siv los ua cov tshuaj pib rau kev sib txuas ntawm bilirubin nrog glucuronic acid.
Cov theem ib txwm ntawm cov tshuaj bilirubin ncaj qha nyob ntawm thaj tsam ntawm 0.1 txog 0.3 mg / dL lossis 1.0 txog 5.1 mmol / L. Yog tias cov ntshav ncaj qha bilirubin nce siab tshaj qhov ntau, nws raug xa mus rau qhov ncaj qha hyperbilirubinemia. Qhov ua rau tam sim no yog cov pob zeb hauv lub gallbladder, hlav qog, rotor syndrome, Dubin - Johnson syndrome, thiab qee yam tshuaj.
Daim duab 01: Tsim cov Bilirubin Direct
Cov kab mob caj ces thiab kev tsis txaus enzyme tuaj yeem ua rau nce qib bilirubin ncaj qha hauv cov ntshav. Direct bilirubin ua ke nrog cov kua tsib thiab xa mus rau cov hnyuv, thiab raug tso tawm. Txawm hais tias nyob rau hauv cov xwm txheej hyperbilirubinemia, bilirubin raug tso tawm hauv cov zis. Raws li qhov xwm txheej no, cov zis tshwm liab.
Dab tsi yog Indirect Bilirubin?
Kev tsis ncaj ntawm bilirubin lossis tsis sib haum xeeb bilirubin yog cov khoom tawg tam sim ntawm hemoglobin. Qhov no yog hom bilirubin tsis hloov pauv. Nyob rau hauv cov xwm txheej ib txwm muaj, cov ntshav tsis ncaj qha bilirubin yuav tsum nyob ib puag ncig 0.2 txog 0.7 mg / dL lossis 3.4 txog 11.9 mmol / L.
Indirect bilirubin yog soluble hauv lipids. Yog li, nws yog lipophilic. Indirect bilirubin yog insoluble hauv dej, thiab nws yog hydrophobic heev. Indirect bilirubin tuaj yeem hla cov plasma membrane yooj yim. Lub toxicity ntawm indirect bilirubin yog siab, tshwj xeeb tshaj yog rau lub paj hlwb. Yog li ntawd, indirect bilirubin hloov mus rau ib tug ntau soluble, non-toxic daim ntawv uas yog conjugated daim ntawv. Indirect albumin yog txuam nrog albumin, uas yog lub ntsiab thauj protein rau bilirubin.
nce qib ntawm indirect bilirubin hauv cov ntshav tuaj yeem yog vim muaj ntau yam xws li nce RBC hemolysis (Erythroblastosisfetalis), cov mob xws li mob cell anemia, kab mob siab, mob cirrhosis thiab vim muaj qee yam tshuaj thiab lwm yam.
Dab tsi zoo sib xws ntawm Direct thiab Indirect Bilirubin?
- Ob leeg yog cov qauv ntawm bilirubin uas yog cov khoom tawg ntawm hemoglobin.
- Ob leeg ua haujlwm ua cov tshuaj biochemical rau kev kuaj lub siab.
- nce hauv ob qho tib si tuaj yeem ua rau hyperbilirubinemia.
Qhov txawv ntawm Direct thiab Indirect Bilirubin yog dab tsi?
Direct Bilirubin vs Indirect Bilirubin |
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| Direct Bilirubin lossis conjugated daim ntawv ntawm bilirubin yog covalently hloov bilirubin uas tau nce solubility. | Indirect Bilirubin yog hom bilirubin uas tsis txuas lossis txuas rau lwm yam tshuaj lom neeg. |
| Hloov kho | |
| Direct bilirubin yog covalently hloov kho thiab yog conjugated nrog glucuronic acid los ntawm cov tshuaj tiv thaiv enzymatic. | Txhua yam kev hloov kho covalent tsis hloov pauv tsis ncaj bilirubin. |
| Direct bilirubin muaj ntau dua solubility hauv dej. | Kev tsis ncaj bilirubin yog tsawg soluble hauv dej thiab ntau soluble hauv lipids. |
| Cov Khoom Noj Protein | |
| Tsis xav tau cov khoom thauj khoom | Bound rau albumin rau kev thauj mus los |
| Txoj kev phem | |
| Direct bilirubin tsis muaj tshuaj lom. | Indirect bilirubin yog tshuaj lom ntau dua. |
Summary – Direct vs Indirect Bilirubin
Direct thiab indirect bilirubin yog ob hom bilirubin hauv cov ntshav. Lawv raug ntsuas raws li ib feem ntawm lub siab ua haujlwm kuaj. Direct bilirubin yog qhov ntau soluble, tsis muaj tshuaj lom thiab yog daim ntawv sib txuas ntawm bilirubin. Direct bilirubin yog conjugated nrog glucuronic acid. Indirect bilirubin yog ib daim ntawv tsis sib txuas ntawm bilirubin. Nws yog tshuaj lom heev thiab tsis tshua muaj soluble hauv dej. Yog li ntawd, nws raug khi rau albumin rau kev thauj mus los. Kev nce qib ncaj qha thiab tsis ncaj ntawm bilirubin qhia txog cov kab mob metabolic thiab kab mob cuam tshuam nrog lub siab. Qhov no yog qhov txawv ntawm qhov ncaj thiab tsis ncaj bilirubin.
Download PDF Direct vs Indirect Bilirubin
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline lub hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Direct thiab Indirect Bilirubin
