Qhov sib txawv tseem ceeb ntawm Michael ntxiv thiab Robinson kev tshaj tawm yog tias Michael ntxiv ua ib qho aliphatic compound, whereas Robinson annulation tsim lub nplhaib qauv.
Txhua, Michael ntxiv thiab Robinson annulation yog cov organic synthesis tshwm sim. Ob qhov kev tawm tsam no tuaj nyob rau hauv qeb ntawm cov tshuaj tiv thaiv ntxiv vim tias ob qho kev cuam tshuam no koom nrog kev sib ntxiv ntawm ob lub tebchaw ua ke, muab cov khoom sib txawv raws li cov khoom kawg.
Michael Ntxiv yog dab tsi?
Michael cov tshuaj tiv thaiv yog qhov sib ntxiv ntawm nucleophilic rau ib qho α, β-unsaturated carbonyl compound. Tsis tas li ntawd, qhov no yog txoj hauv kev zoo tshaj plaws rau kev tsim me me ntawm carbon-carbon bonds. Keeb kwm, qhov kev tawm tsam no tau txhais los ntawm tus kws tshawb fawb Arthur Michael. Cov tshuaj tiv thaiv yog raws li nram no:
Daim duab 01: Michael Reaction
R thiab R' ntawm nucleophile yog pawg electron rho tawm, piv txwv li acyl thiab cyano pawg. B yog lub hauv paus uas muab qhov nruab nrab rau cov tshuaj tiv thaiv thaum koom nrog cov tshuaj tiv thaiv. Ntxiv mus, R' hloov ntawm α, β-unsaturated compound hu ua "Michael txais", thiab feem ntau, nws yog pawg ketone. Tab sis qee zaum nws yog ib pawg nitro. Tsis tas li ntawd, cov tshuaj tiv thaiv rau Michael ntxiv yog raws li hauv qab no:
Daim duab 02: Mechanism rau Michael Ntxiv Cov Lus Teb
Robinson Annulation yog dab tsi?
Robinson annulation yog cov tshuaj tiv thaiv organic uas lub nplhaib tsim los ntawm kev tsim peb C-C daim ntawv cog lus tshiab. Ntxiv mus, cov reactants ntawm cov tshuaj tiv thaiv no yog ib qho ketone thiab methyl vinyl ketone. Ntxiv mus, cov tshuaj tiv thaiv no suav nrog Michael ntxiv ua raws li aldol condensation. Tsis tas li ntawd, nws yog qhov tseem ceeb heev hauv kev tsim cov qauv fused nplhaib. Cov tshuaj tiv thaiv yog raws li nram no:
Daim duab 03: Robinson Annulation Reaction
Ntxiv mus, qhov kev tawm tsam no tau luam tawm thawj zaug los ntawm William Rapson thiab Robert Robinson.
Daim duab 04: Mechanism of Robinson Annulation
Daim duab saum toj no qhia txog lub tswv yim ntawm Robinson annulation. Ntawm no, cov tshuaj tiv thaiv pib nrog kev tawm tsam nucleophilic ntawm ketone ntawm vinyl ketone, uas ua rau nruab nrab Michael adduct. Tom qab ntawd, aldol hom nplhaib kaw tshwm sim, ua rau tsim cov keto cawv, uas tom qab ntawd lub cev qhuav dej, tsim cov khoom lag luam.
Qhov txawv ntawm Michael Ntxiv thiab Robinson Annulation yog dab tsi?
Michael cov tshuaj tiv thaiv yog cov nucleophilic ntxiv ntawm nucleophile rau ib qho α, β-unsaturated carbonyl compound thaum Robinson annulation yog cov tshuaj tiv thaiv organic uas lub nplhaib tsim los ntawm kev tsim peb C-C daim ntawv cog lus tshiab. Yog li ntawd, qhov sib txawv tseem ceeb ntawm Michael ntxiv thiab Robinson annulation yog tias Michael ntxiv tsim ib qho aliphatic compound, whereas Robinson annulation tsim ib lub nplhaib qauv.
Ntxiv mus, Michael ntxiv yog qhov tseem ceeb rau kev tsim cov ntawv cog lus me me C-C thaum Robinson cov tshuaj tiv thaiv yog qhov tseem ceeb hauv kev tsim cov nplhaib fused.
Hauv qab infographic qhia cov ntsiab lus ntxiv ntawm qhov sib txawv ntawm Michael ntxiv thiab Robinson tshaj tawm.
Summary – Michael Ntxiv vs Robinson Annulation
Michael cov tshuaj tiv thaiv yog cov nucleophilic ntxiv ntawm nucleophile rau ib qho α, β-unsaturated carbonyl compound whereas Robinson annulation yog cov tshuaj tiv thaiv organic uas lub nplhaib qauv tsim los ntawm kev tsim peb C-C bonds tshiab. Qhov sib txawv tseem ceeb ntawm Michael ntxiv thiab Robinson annulation yog tias Michael ntxiv ua ib qho aliphatic compound, thaum Robinson annulation tsim ib lub nplhaib qauv.
