Qhov sib txawv tseem ceeb ntawm lincRNA thiab lncRNA yog qhov ntev ntawm RNA. Qhov ntawd yog; cov lincRNAs yog cov hlua ntev ntawm RNA whereas lncRNAs yog piv luv luv ntawm RNA.
RNA lossis Ribonucleic acid yog ib qho tseem ceeb biomolecule uas muaj ntau yam haujlwm. Muaj ntau qhov kev tshawb pom tshiab tshwm sim nyob rau hauv cov nqe lus ntawm RNA. lincRNA thiab lncRNA yog ob qhov kev tshawb pom tshiab no. lincRNA sawv cev rau Ntev Intergenic tsis-coding RNA. Lawv yog cov ntawv sau ntev RNA tam sim no nyob rau hauv mammalian genome. Lawv tshwm sim los pab hauv kev sib txawv ntawm tes thiab kev paub ntawm tes. Hauv kev sib piv, lncRNA lossis ntev tsis-coding RNA yog RNA cov ntawv sau tseg uas tsis ntev dua lincRNA, thiab lawv tsis code rau cov proteins.
lincRNA yog dab tsi?
LincRNA lossis ntev intergenic tsis-coding RNA yog cov chav loj tshaj plaws ntawm RNA pom nyob rau hauv feem ntau cov tsiaj txhu genomes suav nrog tib neeg genome. Lawv yog cov loj thiab ntev RNA cov ntawv sau tseg. Tsis tas li ntawd, lincRNA muaj npe polyA tails, thiab nws yog qhov tseem ceeb hauv kev txheeb xyuas lawv. Tsis tas li ntawd, lwm txoj hauv kev los txheeb xyuas lawv yog los ntawm kev sib luag. Genome-Wide Association cov kev tshawb fawb tam sim no tab tom ua qhov chaw los txheeb xyuas cov lincRNAs.
Daim duab 01: RNA Chemical Structure
Lub luag haujlwm tseem ceeb ntawm lincRNA yog nyob rau hauv cov noob caj noob ces. Lawv ua raws li cov cai tswj hwm thaum lub sijhawm sau ntawv. Lawv kuj koom nrog hauv basal transcription regulatory machinery. lincRNA plays lub luag haujlwm tseem ceeb hauv kev hloov pauv tom qab kev txhais lus uas cuam tshuam nrog RNA splicing. Ntxiv mus, lawv ua raws li nruab nrab molecules thaum splicing.
lncRNA yog dab tsi?
Long non-coding RNA lossis lncRNA yog cov ntawv sau tsis yog RNA. Cov no yog ze li ntawm 200 nucleotides ntev. Lawv qhov loj me yog qhov tseem ceeb ntawm lncRNA. Qee zaum, lawv tseem hu ua Junk RNA. Muaj plaub yam tseem ceeb ntawm lncRNA: intergenic lncRNA, intronic lncRNA, kev nkag siab lncRNA, thiab antisense lncRNA. Cov hom no ncua ntawm lawv cov txheej txheem kev hloov pauv.
Lub luag haujlwm tseem ceeb ntawm lncRNA tseem tsis tau qhia tshwj xeeb. Tab sis, cov kws tshawb fawb ntseeg tias lawv ua lub luag haujlwm tseem ceeb hauv kev kho mob qog noj ntshav vim tias lawv cuam tshuam rau kev hloov pauv ntawm cov qog nqaij hlav cancer. Lawv kuj qhia txog kev ua haujlwm hauv kev tiv thaiv apoptosis, induction ntawm angiogenesis, txhawb kev metastasis, thiab evasion ntawm qog suppressors.
Dab tsi yog qhov zoo sib xws ntawm lincRNA thiab lncRNA?
- lincRNA thiab lncRNA yog ob hom RNA tsim los ntawm ribonucleotides.
- Lawv yog ib leeg-stranded sequence.
- Ob leeg qhia ua haujlwm hauv cov txheej txheem hloov pauv.
- Ntxiv mus, lawv tsis yog-coding RNA.
- Ob daim ntawv thib ob.
- Ntxiv rau, lawv qhia cov ntaub so ntswg tshwj xeeb.
Qhov txawv ntawm lincRNA thiab lncRNA yog dab tsi?
lincRNA hais txog qhov ntev intergenic tsis-coding RNA thaum lncRNA hais txog ntev tsis-coding RNA. lincRNA sawv cev rau pawg ntev tshaj plaws ntawm RNA uas tsis yog-coding. Ntawm qhov tod tes, lncRNA sawv cev rau lwm pab pawg ntev RNA uas muaj kwv yees li 200 nucleotides thiab uas luv dua lincRNA. Qhov tseeb, lincRNA ua rau lncRNA. Yog li, qhov sib txawv tseem ceeb ntawm lincRNA thiab lncRNA yog qhov ntev ntawm txhua RNA. Qhov ntawd yog; lub lincRNA ntev dua lncRNA. Tsis tas li ntawd, lwm qhov sib txawv ntawm lincRNA thiab lncRNA yog tias lincRNA muaj nyob rau hauv cov tsiaj txhu genome thiab muaj nyob rau hauv lub nucleus thaum lncRNAs yog RNA cov ntaub ntawv tawm sab nraum lub nucleus.
Summary – lincRNA vs lncRNA
lincRNA thiab lncRNA yog ob hom tshiab ntawm RNA. lincRNA stands rau ntev intergenic tsis-coding RNA, thiab lawv yog RNA ntev tshaj plaws nyob rau hauv tib neeg genome. Ntawm qhov tod tes, lncRNA lossis ntev tsis-coding RNA yog lwm hom RNA uas yog RNA cov ntawv sau tseg. Txawm li cas los xij, lncRNAs luv dua li lincRNA. Ntxiv mus, lawv muaj nyob ib ncig ntawm 200 nucleotides hauv lawv cov kab ke. Ob hom tshiab no ntawm RNA ua lub luag haujlwm tseem ceeb hauv kev hloov pauv cov txheej txheem. Lawv kuj ua lub luag haujlwm tseem ceeb hauv kev hloov kho tom qab kev txhais lus. Ob hom RNA tuaj yeem txheeb xyuas los ntawm kev sib txuas. Nov yog cov ntsiab lus ntawm qhov sib txawv ntawm lincRNA thiab lncRNA.
