Qhov Tseem Ceeb Qhov txawv - Polycythemia vs Polycythemia Vera
Polycythemia txhais tau tias yog qhov nce ntawm cov cell liab, hemoglobin, thiab PCV. Tus mob no tuaj yeem yog vim muaj qhov sib txawv. Thaum tus neeg mob tau txais polycythemia raws li qhov tshwm sim ntawm tus kab mob hauv qab, nws yog hu ua Secondary polycythemia. Ntawm qhov tod tes, polycythemia vim yog thawj qhov kev cuam tshuam hauv lub cev lub cev lub luag haujlwm rau kev sib txuas ntawm hemoglobin yog hu ua thawj polycythemia. Polycythemia vera yog qhov tshwm sim ntau tshaj plaws ntawm thawj polycythemia, thiab nws txhais tau tias yog clonal stem cell disorder uas muaj kev hloov pauv hauv pluripotent progenitor cell uas ua rau muaj kev loj hlob ntau ntawm erythroid, myeloid thiab megakaryocytic progenitor hlwb. Qhov sib txawv tseem ceeb ntawm polycythemia thiab polycythemia vera yog polycythemia yog qhov nce ntawm cov cell liab, hemoglobin, thiab PCV thaum polycythemia vera yog ib qho ua rau polycythemia.
Polycythemia yog dab tsi?
Polycythemia txhais tau tias yog qhov nce ntawm cov cell liab, hemoglobin, thiab PCV. Muaj ob lub ntsiab lus ntawm polycythemia li erythrocytosis kiag li thiab txheeb ze erythrocytosis; Nyob rau hauv erythrocytosis kiag li, muaj tseeb nce nyob rau hauv lub cell liab ntim thiab nyob rau hauv cov txheeb ze erythrocytosis, muaj ib tug txo nyob rau hauv lub plasma ntim nrog ib tug ib txwm liab cell ntim.
Caus
YPrimary Polycythemia
- YPolycythemia Vera
- Kev hloov pauv hauv erythropoietin receptor
- High oxygen affinity hemoglobins
Secondary Polycythemia
– Hypoxic nce hauv erythropoietin
- siab altitude
- mob ntsws mob ntsws
- mob plawv
- Pleev apnea
- Morbid obesity
- Kev haus luam yeeb hnyav
- nce affinity ntawm hemoglobin
– Tsis tsim nyog nce hauv erythropoietin
- rau lub raum cell carcinomas
- YHepatocellular carcinomas
- YCerebral hemangioblastomas
- YMassive uterine leiomyoma
- Kev tswj hwm ntawm erythropoietin
Cov qib erythropoietin yog ib txwm lossis nce hauv theem nrab polycythemia.
Secondary polycythemias raug kho los ntawm kev tswj hwm ntawm qhov laj thawj. Txhua tus qog uas ncaj qha lossis tsis ncaj qha ua rau muaj kev nce hauv erythropoietin ntau lawm yuav tsum tau phais. Cov neeg haus luam yeeb hnyav yuav muaj feem cuam tshuam los ntawm cov polycythemia thib ob vim tias qhov nce ntawm carboxylated hemoglobin txhawb nqa txoj hauv kev ntawm erythropoietin ntau lawm. Thrombosis, hemorrhage thiab plawv tsis ua hauj lwm yog cov teeb meem ntawm theem nrab polycythemia. Venesection kuj tseem tuaj yeem pab daws cov tsos mob, tshwj xeeb tshaj yog tias PCV ntau dua 0.55/micro liter.
YPolycythemia Vera yog dab tsi?
Polycythemia vera yog ib qho kab mob clonal qia cell uas muaj kev hloov pauv hauv pluripotent progenitor cell, ua rau muaj ntau dhau ntawm erythroid, myeloid thiab megakaryocytic progenitor hlwb. Feem coob ntawm cov neeg mob raug mob los ntawm tus mob no tau txais kev hloov pauv hauv JAK2 noob.
Tshuaj Kho Mob
Muaj qhov pib tsis txaus ntseeg. Qhov kev nthuav qhia ib txwm yog tus neeg mob laus dua 60 xyoo uas yws yws ntawm kev nkees, kev nyuaj siab, vertigo, thiab tinnitus.
Lwm yam tsis yog cov tsos mob tshwj xeeb no, tus neeg mob tuaj yeem muaj,
- Hypertension
- Angina
- Ntxhais lus tsis sib haum
- Ntshav Siab
- khaus khaus tom qab da dej zoo
- Gout
- Hemorrhages
- Plethora
Kev Ntsuas Ntsuas
Yam tseem ceeb
- Hemoglobin ntau dua 185 g / l hauv cov txiv neej thiab 165 g / l hauv cov poj niam
- Lub xub ntiag ntawm JAK2 kev hloov pauv
Yam Me Me
- pob txha pob txha biopsy qhia hypercellularity rau hnub nyoog nrog panmyelosis
- Txo cov ntshav erythropoietin qib
- Endogenous erythroid tsim colony hauv vitro
Yam tsawg kawg ib qho me me nrog rau ob qho tseem ceeb thiab ib qho kev ntsuas loj nrog ib qho ntawm ib qho me me yuav tsum muaj los kuaj xyuas PV.
Kev tswj hwm
Lub hom phiaj ntawm kev tswj hwm yog kev saib xyuas cov ntshav suav kom tsis txhob muaj teeb meem xws li thrombosis. Cov kev cuam tshuam hauv qab no yog qhov tseem ceeb hauv kev tswj hwm PV
- Venesection
- Tshuaj khomob
- Kev tswj hwm cov tshuaj aspirin qis rau cov neeg mob uas tau mob thrombotic yav dhau los.
- Kev tswj hwm ntawm anagrelide txhawm rau tiv thaiv megakaryocyte sib txawv
30% ntawm cov neeg mob PV tuaj yeem muaj Myelofibrosis, thiab 5% ntawm cov neeg mob tuaj yeem kis tau tus mob leukemia.
Dab tsi zoo sib xws ntawm Polycythemia thiab Polycythemia Vera?
Polycythemia vera yog qhov tseem ceeb tshaj plaws ua rau thawj polycythemia
Qhov txawv ntawm Polycythemia thiab Polycythemia Vera yog dab tsi?
YPolycythemia vs Polycythemia Vera |
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| Polycythemia txhais tau tias yog qhov nce ntawm cov cell liab, hemoglobin, thiab PCV. | Polycythemia vera yog ib qho kab mob clonal qia cell uas muaj kev hloov pauv hauv pluripotent progenitor cell ua rau muaj kev loj hlob ntau dhau ntawm erythroid, myeloid thiab megakaryocytic progenitor cells. |
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YPrimary Polycythemia
Secondary Polycythemia– Hypoxic nce hauv erythropoietin
– Tsis tsim nyog nce hauv erythropoietin
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Polycythemia vera, uas yog qhov tseem ceeb tshaj plaws ua rau thawj polycythemia, yog vim muaj kev hloov hauv JAK2 noob. |
| Kev tswj hwm | |
|
Lub hom phiaj ntawm kev tswj hwm yog kev saib xyuas cov ntshav suav kom tsis txhob muaj teeb meem xws li thrombosis. Cov kev cuam tshuam hauv qab no yog qhov tseem ceeb hauv kev tswj hwm PV
30% ntawm cov neeg mob PV tuaj yeem muaj Myelofibrosis thiab 5% ntawm cov neeg mob tuaj yeem kis tau tus mob leukemia. |
| Kev nyuaj siab | |
| Thrombosis, plawv tsis ua hauj lwm, thiab hemorrhages yog cov teeb meem tseem ceeb ntawm polycythemia vim muaj ntau yam sib txawv ntawm polycythemia vera. | Ntxiv rau qhov mob thrombosis, mob plawv tsis ua haujlwm, thiab hemorrhage, cov neeg mob tuaj yeem tsim Myelofibrosis thiab myeloblastic leukemia. |
Summary – Polycythemia vs Polycythemia Vera
Polycythemia txhais tau tias yog qhov nce ntawm cov cell liab, hemoglobin, thiab PCV. Polycythemia vera yog ib hom kab mob clonal qia cell uas muaj kev hloov pauv hauv pluripotent progenitor cell uas ua rau muaj kev loj hlob ntau dhau ntawm erythroid, myeloid thiab megakaryocytic progenitor hlwb. Yeej, tsis muaj qhov sib txawv ntawm Polycythemia thiab Polycythemia Vera. Polycythemia vera yog ib qho ntawm ntau qhov ua rau polycythemia uas yog vim muaj qhov tsis xws ntawm JAK2 noob.
