Qhov Tseem Ceeb Qhov txawv - Graves Disease vs Hashimoto
Cov kab mob uas yog vim lub cev tiv thaiv kab mob los ntawm lub cev tawm tsam nws cov hlwb thiab cov ntaub so ntswg hu ua autoimmune disorders. Graves kab mob thiab Hashimoto yog ob yam kab mob autoimmune uas cuam tshuam rau cov qauv thiab kev ua haujlwm ntawm cov thyroid caj pas. Txawm li cas los xij, qhov kawg ntawm pathological tshwm sim ntawm ob qho xwm txheej no sib txawv heev ntawm ib leeg. Hauv Graves tus kab mob, cov thyroid hormone theem nce siab ua rau hyperthyroidism thaum, hauv Hashimoto, cov thyroid hormone theem poob qis dua tus nqi sib npaug, ua rau hypothyroidism. Qhov kev tsis sib haum xeeb hauv qib hormone yog qhov sib txawv tseem ceeb ntawm Graves kab mob thiab Hashimoto.
Dab tsi yog Graves Disease?
Kab mob Graves yog ib qho autoimmune thyroid disorder uas tsis paub txog etiology.
Pathogenesis
Ib autoantibody ntawm IgG hom hu ua Thyroid Stimulating Immunoglobulin khi rau TSH receptors hauv cov thyroid caj pas thiab ua raws li kev ua ntawm TSH. Raws li qhov tshwm sim ntawm qhov kev txhawb zog no, muaj ntau ntau ntawm cov thyroid hormones cuam tshuam nrog hyperplasia ntawm cov thyroid follicular hlwb. Qhov kawg tshwm sim yog qhov diffuse o ntawm cov thyroid caj pas.
Qhov nce ntxiv los ntawm cov thyroid hormones nthuav qhov ntim ntawm cov ntaub so ntswg retro-orbital. Qhov no nrog rau cov edema ntawm cov nqaij ntshiv extraocular, tsub zuj zuj ntawm cov ntaub ntawv extracellular matrix, thiab infiltration ntawm periocular qhov chaw los ntawm lymphocytes thiab cov ntaub so ntswg rog tsis muaj zog cov nqaij ntshiv extraocular, thawb lub qhov muag rau pem hauv ntej.
Daim duab 01: Exophthalmos hauv Graves tus kab mob
Morphology
Muaj qhov nthuav dav ntawm cov thyroid caj pas. Txiav seem yuav pom liab meaty tsos. Follicular cell hyperplasia uas yog tus cwj pwm los ntawm qhov muaj ntau ntawm cov follicular me me yog lub cim microscopic feature.
Tshuaj Kho Mob
Qhov txawv qhov chaw kho mob ntawm Graves tus kab mob yog,
- Diffuse goiter
- Exophthalmos
- Periorbital myoedema
Ntxiv rau cov tsos mob no, tus neeg mob tuaj yeem muaj cov tsos mob hauv qab no vim tias muaj cov thyroid hormone ntau ntxiv.
- poob phaus thiab nce qab los noj mov
- Zoo plab vim plab zom mov ntau
- Kev mob siab rau lub suab ua rau muaj kev tshee hnyo, pw tsaug zog, ntxhov siab vim thiab cov leeg tsis muaj zog.
- Kev mob plawv xws li tachycardia, palpitations, thiab arrhythmias.
Kev tshawb nrhiav
- Kev kuaj cov thyroid ua haujlwm kom paub meej tias thyrotoxicosis
- Tshuaj xyuas seb muaj cov thyroid stimulating immunoglobulin hauv cov ntshav.
Kev tswj hwm
kho mob
Kev tswj hwm cov tshuaj tiv thaiv thyroid xws li carbimazole thiab methimazole yog qhov zoo heev. Qhov tshwm sim feem ntau cuam tshuam nrog kev siv cov tshuaj no tas mus li yog agranulocytosis, thiab txhua tus neeg mob uas nyob rau hauv cov tshuaj tiv thaiv thyroid yuav tsum tau qhia kom nrhiav kev kho mob tam sim ntawd thaum muaj kub taub hau lossis mob caj pas..
- xov tooj cua kho nrog xov tooj cua iodine
- Kev phais ntawm cov thyroid caj pas. Qhov no yog qhov kev xaiv zaum kawg uas tsuas yog siv thaum kev kho mob tsis ua tiav qhov kev xav tau.
YHashimoto yog dab tsi?
Hashimoto thyroiditis yog ib yam kab mob autoimmune uas yog ib qho ua rau hypothyroidism, tshwj xeeb tshaj yog nyob rau thaj chaw uas tsis muaj iodine deficiency.
Tus mob no yog tus yam ntxwv los ntawm kev puas tsuaj zuj zus ntawm cov thyroid follicles vim yog cov kab mob autoimmune-mediated lymphocytic infiltration, thaum kawg ua rau cov thyroid tsis ua haujlwm.
Morphology
Cov thyroid caj pas yog diffusely loj, thiab cov ntu ntuag qhia tau tias daj ntseg ruaj khov thiab cov tsos zoo nrog tsis meej nodularity. Kev mob siab rau ntawm cov thyroid caj pas los ntawm cov ntshav plasma thiab lymphocytes tuaj yeem pom nyob rau hauv lub tshuab tsom.
Tshuaj Kho Mob
Feem ntau, cov poj niam hnub nyoog nruab nrab feem ntau yuav raug cuam tshuam los ntawm tus mob no.
- Diffuse goiter
- Nyhav nce
- Cias intolerance
- Kev nyuaj siab
- Txoj kev libido
- puffy eyes
- Arthralgia thiab myalgia
- Menorrhagia
- Kev xav
- Neeg
Nyob zoo ib tsoom niam txiv kwv tij neej tsas sawv daws.
Cov menyuam yaus uas muaj cov thyroid caj pas tuaj yeem muaj cretinism uas yog tus cwj pwm los ntawm kev loj hlob ntawm lub hlwb thiab lub cev tsis zoo.
Daim duab 02: Hashimoto
Kev nyuaj siab
Hashimoto thyroiditis nce qhov yuav muaj
- Lwm yam kab mob autoimmune xws li SLE
- Malignancies xws li non-Hodgkin lymphoma thiab papillary carcinoma ntawm thyroid caj pas.
Kev tshawb nrhiav
- Kev ntsuas ntshav ntshav TSH qib uas txawv txav hauv hypothyroidism
- T4 qib txo qis heev
- Tshuaj xyuas qhov muaj cov tshuaj tiv thaiv kab mob hauv lub cev - hauv Hashimoto thyroiditis, qib ntawm antithyroid peroxidase, antithyroid thyroglobulin, thiab antithyroid microsomal tshuaj tiv thaiv yog qhov txawv txav.
Kev tswj hwm
Hypothyroidism yog tswj hwm los ntawm kev hloov kho nrog levothyroxine.
Dab tsi zoo sib xws ntawm Graves Disease thiab Hashimoto
- Ob leeg yog kab mob autoimmune uas cuam tshuam rau cov thyroid caj pas.
- Cov thyroid caj pas yog diffusely loj nyob rau hauv ob qho tib si Graves kab mob thiab Hashimoto thyroiditis.
Qhov txawv ntawm Graves Disease thiab Hashimoto yog dab tsi?
YGraves Disease vs Hashimoto |
|
| Kab mob Graves yog ib qho autoimmune thyroid disorder uas tsis paub txog etiology. | Hashimoto thyroiditis yog ib qho kab mob autoimmune uas yog ib qho ua rau hypothyroidism tshwj xeeb tshaj yog nyob rau thaj chaw uas tsis muaj iodine deficiency. |
| Qhov no ua rau hyperthyroidism. | Qhov no ua rau hyperthyroidism. |
| thyroid boil | |
| Muaj hyperplasia ntawm cov thyroid follicular hlwb. | Cov thyroid follicles raug rhuav tshem, thiab muaj kev nkag mus ntawm cov thyroid cov ntaub so ntswg los ntawm cov ntshav plasma thiab lymphocytes. |
| Cross section | |
| Cov hlais tawm los ntawm cov qog thyroid cuam tshuam los ntawm Graves muaj cov nqaij liab liab. | Hla ntu muaj xim daj ntseg, ruaj khov thiab zoo nkauj. |
| Tshuaj kho mob | |
|
Cov tsos mob hauv qab no tau pom hauv Hashimoto thyroiditis vim qhov tshwm sim hypothyroidism. · Muaj kab mob goiter · Ntsuag · Nyhav nce · txias intolerance · Kev nyuaj siab · pluag libido · Puffy eyes · cov plaub hau qhuav thiab nkig · Arthralgia thiab myalgia · cem quav · Menorrhagia · Psychoses · lag ntseg |
| TSH Levels | |
| TSH qib serum txo, tab sis T4 qib nce. | TSH qib nce, tab sis qib T4 txo. |
| Antibodies | |
| Thyroid Stimulating Immunoglobulin yog cov tshuaj tiv thaiv uas nws qib nce hauv Graves tus kab mob. | Nyob rau hauv Hashimoto thyroiditis, cov qib ntawm antithyroid peroxidase, antithyroid thyroglobulin, thiab antithyroid microsomal tshuaj tiv thaiv yog txawv txav. |
| Kev sib cuag rau Cancer | |
| Tsis muaj kev cuam tshuam nrog kev mob qog noj ntshav. | Hashimoto thyroiditis nce txoj hauv kev muaj papillary carcinomas ntawm cov thyroid caj pas thiab non-Hodgkin lymphomas. |
| Kev Tswj Xyuas Kev Kho Mob | |
| Kev tswj hwm kev kho mob yog los ntawm kev tswj hwm cov tshuaj tiv thaiv thyroid xws li carbimazole. Kev kho hluav taws xob nrog hluav taws xob iodine thiab kev phais tshem tawm ntawm cov thyroid caj pas yog lwm txoj kev kho mob. | Kev tswj hwm kev kho mob yog kev hloov kho kev siv levothyroxine. |
Summary – Graves Disease vs Hashimoto
Graves kab mob thiab Hashimoto yog ob yam kab mob autoimmune uas cuam tshuam rau cov thyroid caj pas. Hauv Graves tus kab mob, cov thyroid hormone theem nce ua rau hypothyroidism, tab sis nyob rau hauv Hashimoto, cov thyroid hormone theem yog txawv txav. Qhov no yog qhov sib txawv ntawm Graves kab mob thiab Hashimoto.
Download PDF Version of Graves Disease vs Hashimoto
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Graves Disease thiab Hashimoto
