Qhov Tseem Ceeb - CD4 Cells vs CD8 Cells
Nyob rau hauv cov ntsiab lus ntawm kev tiv thaiv kab mob ntawm tes, T hlwb, feem ntau hu ua T lymphocytes, ua lub luag haujlwm tseem ceeb. Txij li thaum lawv loj hlob hauv thymus los ntawm thymocytes, lawv raug hu ua T hlwb. T hlwb muaj ob pawg loj: T pab (Th) hlwb thiab cytotoxic T hlwb (Tc). Vim muaj ob hom glycoproteins sib txawv, piv txwv li, CD4 thiab CD8, nyob rau ntawm lub cell ntawm Th cells thiab Tc cells, lawv raug xa mus rau CD4 + T cells thiab CD8 + T hlwb, raws li. CD4+ T hlwb paub txog cov antigens uas nthuav tawm los ntawm Major Histocompatibility Complex (MHC) Class II thiab qhib kom tua cov kab mob hauv lub cev los ntawm kev tso tawm cytokines. CD8+ T hlwb tsuas paub txog cov antigens uas nthuav tawm los ntawm MHC Class I thiab rhuav tshem cov qog hlwb thiab cov kab mob ncaj qha. Qhov no yog qhov sib txawv tseem ceeb ntawm CD4 hlwb thiab CD8 hlwb.
CD4 Cells yog dab tsi?
CD4 yog suav tias yog glycoprotein uas ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob. CD4 nyob ntawm qhov chaw ntawm qee lub cev tiv thaiv kab mob xws li dendritic cells, T pab hlwb, macrophages, thiab monocytes. CD4 protein feem ntau yog encoded los ntawm cov noob hu ua CD4 noob hauv tib neeg. CD4 muaj ib tug luv luv cytoplasmic tus Tsov tus tw uas muaj ib tug tshwj xeeb amino acid ib ntus uas pab pib thiab sib txuas lus nrog tyrosine kinase Lck. Qhov no Lck yog xav tau los qhib lub molecular Cheebtsam ntawm lub signaling cascade ntawm ib tug T cell uas yog activated. CD4 belongs rau immunoglobulin superfamily ib yam li lwm cov cell nto receptors. Nws muaj plaub lub immunoglobulin domains D1 rau D4 Cov domains no nyob rau ntawm lub ntsej muag extracellular ntawm cov hlwb. D1 and D3 yog zoo ib yam li immunoglobulin variable (IgV) domains thaum D2 and D 4 zoo ib yam li immunoglobulin tas li (IgC) domains. CD4 cuam tshuam nrog β2-domain ntawm loj histocompatibility complex (MHC) chav kawm II molecules nrog kev pab los ntawm D1 domain. Yog li, cov CD4 no dhau los ua tshwj xeeb rau cov antigens uas tsuas yog nthuav tawm los ntawm MHC chav kawm II.
Daim duab 01: CD4 Cells
CD4 yog lub npe hu ua co-receptor ntawm T cell receptor (TCR). Qhov no pab hauv kev sib txuas lus nrog cov tshuaj tiv thaiv kab mob. CD4 thiab TCR complex txhua khi rau cov cheeb tsam tshwj xeeb ntawm cov tshuaj tiv thaiv-tam sim no nrog cov kev cuam tshuam ntawm extracellular D 1domain. Muaj cov kab mob uas tshwm sim vim qhov tsis xws luag ntawm CD4. Piv txwv li, hauv kev kis kab mob HIV, tus kab mob HIV-1 nkag mus rau tus tswv tsev T-cells los ntawm CD4, thiab tus naj npawb ntawm T hlwb uas qhia CD4 kuj raug txo qis.
CD8 Cells yog dab tsi?
CD8 suav tias yog transmembrane glycoprotein uas ua haujlwm hauv lub cev tsis muaj zog. CD8 tseem hu ua co-receptor ntawm T cell receptor (TCR). Zoo ib yam li TCR, CD8 khi rau qhov loj histocompatibility complex (MHC) chav kawm I protein tshwj xeeb. CD8 feem ntau yog nyob rau saum npoo ntawm cytotoxic T hlwb thiab cortical thymocytes, natural killer cells, thiab dendritic cells. Ib yam li CD4, CD8 kuj belongs rau immunoglobulin superfamily. Txhawm rau ua kom yooj yim rau txoj haujlwm, CD8 tsim ib qho dimer uas muaj CD8 saw khub. Cov hom CD8 feem ntau yog CD8-α thiab CD8-β. Nws muaj qhov sib txawv ntawm immunoglobulin (IgV) zoo li cov kab mob sib txuas ntxiv mus rau daim nyias nyias los ntawm tus nplaig thiab tus Tsov tus tw intracellular. Nquag, IgV, zoo li extracellular domain ntawm hom CD8-α, koom tes nrog chav kawm I MHC molecules. Qhov kev sib raug zoo ntawm cov molecules no ua rau cytotoxic T cell's T cell receptor nruj nreem khi ua ke nrog lub hom phiaj ntawm tes thaum lub sijhawm ua kom muaj qhov tshwj xeeb antigen.
Daim duab 02: CD8 Cells
Dab tsi zoo sib xws ntawm CD4 Cells thiab CD8 Cells?
- CD4 thiab CD8 yog cov proteins uas pom nyob rau saum npoo ntawm lawv cov hlwb.
- Ob leeg CD4 thiab CD8 yog tsim nyob rau hauv thymus thiab nthuav qhia T-cell receptor.
- Ob leeg ntawm lawv suav tias yog glycoproteins thiab muaj nyob rau hauv immunoglobulin superfamily.
- Ob leeg muaj peev xwm khi rau MHC molecules thaum tsis muaj T cell receptor. CD4 thiab CD8 kuj muaj peev xwm txhim kho cov antigen-induced IL-2 ntau lawm nrog cov txheej txheem sib txawv.
Qhov txawv ntawm CD4 Cells thiab CD8 Cells yog dab tsi?
CD4 Cells vs CD8 Cells |
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| CD4 yog lub npe hu ua T pab hlwb. | CD8 yog lub npe hu ua cytotoxic T cells. |
| Antigen Recognition | |
| CD4 hlwb paub txog cov tshuaj tiv thaiv uas nthuav tawm los ntawm Major Histocompatibility Complex (MHC) Class II. | CD8 hlwb tsuas paub txog antigens nthuav tawm los ntawm MHC Class I. |
| Kev Ua Haujlwm | |
| CD4 hlwb nyob rau ntawm qhov chaw ntawm qee lub cev tiv thaiv kab mob xws li dendritic cells, T pab hlwb, macrophages, thiab monocytes. | Cellulose yog cov qauv linear nrog linear β glucose chains. |
| Kev Ua Haujlwm | |
| Hauv CD4, Antigen nthuav tawm cov hlwb yuav tsum tau qhib kom tua cov kab mob hauv lub cev los ntawm kev tso tawm cytokines | Hauv CD8, cov kab mob kis tau thiab cov qog hlwb raug puas tsuaj ncaj qha. |
| CD4 hlwb yog lub luag haujlwm rau kev nthuav qhia antigen rau B hlwb. | CD8 hlwb yog lub luag haujlwm rau indirect phagocytosis. |
Summary – CD4 Cells vs CD8 Cells
T hlwb yog qhov tseem ceeb hauv kev tiv thaiv kab mob ntawm tes. Lawv loj hlob hauv thymus los ntawm thymocytes. T hlwb txawv los ntawm lwm yam lymphocytes vim muaj T cell receptor. T cell muaj ob hom: Th cells thiab Tc cells. Cov glycoproteins CD4 thiab CD8 muaj nyob rau ntawm Th cells thiab Tc cells feem. CD4+ T hlwb paub txog cov antigens uas nthuav tawm los ntawm Major Histocompatibility Complex (MHC) Class II thiab qhib kom tua cov kab mob hauv lub cev los ntawm kev tso tawm cytokines. CD8+ T hlwb tsuas paub txog cov antigens uas nthuav tawm los ntawm MHC Class I thiab rhuav tshem cov qog hlwb thiab cov kab mob ncaj qha. Qhov no yog qhov txawv ntawm CD4 hlwb thiab CD8 hlwb.
Download PDF Version of CD4 Cells vs CD8 Cells
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv nruab nrab ntawm CD4 Cells thiab CD8 Cells
