Qhov Tseem Ceeb Qhov txawv - Addison Disease vs Cushing Syndrome
Ob tus kab mob Addison thiab Cushing syndrome yog cov kab mob endocrine. Qhov sib txawv tseem ceeb ntawm Addison tus kab mob thiab Cushing syndrome yog tias muaj cov tshuaj hormones tsis txaus ntawm cortisol thiab aldosterone hauv Addison tus kab mob thaum muaj ntau tshaj cortisol hauv Cushing syndrome. Nws yog ib qho tseem ceeb kom paub qhov txawv ntawm Addison tus kab mob thiab Cushing syndrome thiaj li kuaj tau thiab kho lawv kom raug.
Cushing Syndrome yog dab tsi?
Ib txheej ntawm cov chaw kho mob uas tshwm sim tas li ua ke vim tias qhov kev txhawb siab ntau dhau ntawm glucocorticoid receptors hu ua Cushing syndrome.
Caus
- Iatrogenic ua rau xws li kev tswj hwm lub sijhawm ntev ntawm glucocorticoids
- Pituitary adenomas - thaum kho cov yam ntxwv vim yog pituitary adenoma uas tus mob hu ua tus kab mob Cushing
- Malignancies xws li bronchial carcinomas, adrenal carcinomas, thiab me me ntsws carcinomas
- ACTH ywj pheej macronodular hyperplasia
- cawv ntau dhau
- kev nyuaj siab
- Primary rog
Tshuaj Kho Mob
- Hair thinning
- hirsutism
- pob txuv
- Plethora
- Kev puas siab ntsws
- Cataract
- Moon face
- Poob qhov siab thiab mob nraub qaum vim kev sib tsoo pob txha
- Osteoporosis
- tiv thaiv kab mob
- Central rog
- Striae
- Hypertension
Nyob zoo ib tsoom niam txiv kwv tij neej tsas
Daim duab 01: Cov tsos mob ntawm Cushing Syndrome
Qhov muaj ob peb yam mob tshwm sim, txawm li cas los xij, tsis yog ib qho pov thawj txaus los kuaj pom tus mob Cushing. Yuav muaj kev hloov pauv hauv qib glucocorticoid ntawm lub cev vim muaj lwm yam mob xws li kev rog thiab kev nyuaj siab. Yog li ntawd, txhua qhov kev tsis txaus ntseeg ntawm Cushing syndrome yuav tsum raug lees paub los ntawm kev tshawb xyuas ntxiv. Cov tshuaj keeb kwm ntawm tus neeg mob yog qhov tseem ceeb heev kom tsis suav nrog txhua qhov ua rau iatrogenic. Yog tias tus mob Cushing yog vim muaj qhov tsis zoo, qhov tshwm sim ntawm qhov chaw kho mob feem ntau tshwm sim sai, thiab muaj kev sib koom ua ke cachexia.
Kev tshawb nrhiav
vim hais tias ntawm cov kev txwv nyob rau hauv qhov tshwj xeeb thiab kev txawj ntse tau ua ke thaum mus txog qhov raug ntawm cov txheej txheem. Kev tshawb nrhiav tsom mus rau,
- Tshaj tawm seb tus neeg mob puas muaj Cushing syndrome
- Kev txheeb xyuas tus kab mob hauv qab
Tsim kom muaj Cushing syndrome
Yog tias ob ntawm peb qhov kev ntsuas tau hais hauv qab no muab cov txiaj ntsig zoo, qhov no lees paub tias muaj tus mob Cushing.
- nce hauv 24-teev cov zis tsis muaj cortisol
- Tsis muaj peev xwm txo qis cov ntshav cortisol los ntawm kev tswj hwm ntawm qhov ncauj dexamethasone
- Hloov pauv hauv lub circadian atherosclerosis ntawm cortisol secretion
Kev Txiav Txim Rau Hauv Pathology
ACTH qib yog ntsuas rau lub hom phiaj ntawm kev tsim cov kab mob hauv qab. Yog tias qib qis qis, qhov no taw qhia rau qhov ua rau adrenal. Ntawm qhov tod tes, qhov txawv txav siab ntawm ACTH qhia txog qhov ua rau pituitary.
MRI thiab CT scans tuaj yeem ua tiav txhawm rau txheeb xyuas cov qog nqaij hlav hauv hlwb txhawm rau txhawm rau kuaj mob.
Kev tswj hwm
Nyob rau hauv kev tswj hwm tus mob Cushing, qhov tseem ceeb yog muab rau cov kev phais. Ntau yam tshuaj tau muab coj los ua kom cov qib cortisol nyob rau ntawm qhov chaw kom txog thaum kev phais tiav. Kev tswj hwm nws txawv nyob ntawm tus kab mob hauv qab.
Cushing Disease
- YTrans sphenoidal phais
- Laparoscopic ob tog adrenalectomy
YAdrenal Tumors
- Laparoscopic adrenal phais
- Radiotherapy
Tus Kab Mob Addison yog dab tsi?
Qhov adrenocortical insufficiency tshwm sim los ntawm kev puas tsuaj lossis kev ua haujlwm tsis zoo ntawm adrenal cortex hu ua Addison tus kab mob. Thaum lub sijhawm kho mob tshwm sim, kwv yees li 90% ntawm ob qho tib si adrenal cortices tau raug rhuav tshem.
Caus
- kab mob autoimmune
- tuberculosis
- Neoplasms
- Nyob rau hauv necrosis
- Amyloidosis
- YHemochromatosis
- Waterhouse-Friedrichsen syndrome tom qab meningococcal septicemia
- YBilateral adrenalectomy
Tshuaj Kho Mob
Vim tias tag nrho cov adrenal cortex raug cuam tshuam, kev tsim cov cortisols thiab aldosterone tau txo qis heev. Qhov kev tsis txaus ntawm hormonal no ua rau muaj ntau yam kev kho mob tshwm sim.
Cov tsos mob vim Cortisol Deficiency
Kev qaug zog thiab qaug zog
Kev txo qis hauv cov qib cortisol ua rau cov tshuaj insulin rhiab heev ntawm cov ntaub so ntswg hauv lub cev, ua rau cov ntshav qab zib. Glycogen khaws cia hauv daim siab yog siv los them nyiaj rau lub xeev hypoglycemic, thiab nrog rau lawv cov depletion, cov txheej txheem them nyiaj kuj ua tsis tiav, ua rau tus neeg mob qaug zog thiab qaug zog.
- tiv thaiv kab mob
- Cov leeg tsis muaj zog
- Kev ntxhov siab
- Mood Change
- Hypotension
- poob qis
Cov tsos mob vim Aldosterone Deficiency
- Arrhythmias - vim qhov tshwm sim hyponatremia thiab hyperkalemia
- CNS cuam tshuam
- Ntaus
- Zoo plab
- Vim
- YMetabolic acidosis
- Hypovolemia
- Hypotension
Lwm qhov tshwj xeeb ntawm kev kho mob ntawm tus kab mob Addison yog hyperpigmentation vim nce qib ACTH uas muaj MSH zoo li kev ua si.
Daim duab 02: Lub cev tsis zoo tawm tswv yim voj rau glucocorticoids
Adrenal Crisis
Adrenal ntsoog yog ib qho kev kho mob xwm txheej ceev uas tus neeg mob muaj kub taub hau, ntuav, raws plab thiab txo qis hauv cov ntshav siab. Yog tias tsis kho tam sim ntawd tus neeg mob tuaj yeem tuag ntawm hypovolemic shock. Qhov no tuaj yeem tshwm sim txawm nyob rau hauv cov tib neeg uas tsis muaj keeb kwm yav dhau los ntawm cov kab mob adrenal. Qhov feem ntau ua rau muaj teeb meem ntawm adrenal yog ob sab adrenal hemorrhage, uas feem ntau pom nyob rau hauv cov me nyuam mos thiab cov neeg laus noj tshuaj anticoagulant xws li Warfarin. Cov mob no yog kho nrog glucocorticoids thiab saline.
Kev kho mob
Tus kab mob Addison yog kho los ntawm kev tswj hwm cov tshuaj hormones hluavtaws los kho cov qib qub ntawm aldosterone thiab cortisol.
Dab tsi zoo sib xws ntawm Addison Kab Mob thiab Cushing Syndrome?
Ob qho xwm txheej no yog vim muaj kev hloov pauv ntawm cov qauv lossis kev ua haujlwm hauv lub qog adrenal
Qhov txawv ntawm Addison Kab Mob thiab Cushing Syndrome yog dab tsi?
Addison Disease vs Cushing Syndrome |
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| Addison tus kab mob yog qhov tsis txaus ntawm adrenocortical tshwm sim los ntawm kev puas tsuaj lossis ua haujlwm tsis zoo ntawm adrenal cortex. | Cushing syndrome yog ib txheej ntawm cov kev kho mob uas tshwm sim tas li ua ke vim muaj kev ua kom ntau dhau ntawm glucocorticoid receptors. |
| Cortisol thiab Aldosterone Levels | |
| Nyob rau hauv Addison tus kab mob, ob qho tib si cortisol thiab aldosterone qib raug cuam tshuam. | Tsuas yog qib cortisol cuam tshuam hauv Cushing syndrome. |
| Txoj kev cuam tshuam ntawm Cortisol Level | |
| Cortisol qib txo qis hauv Addison tus kab mob. | Cushing syndrome yog tus cwj pwm los ntawm kev nce qib hauv cortisol. |
| Symptoms | |
| Hypotension thiab hypoglycemia yog qhov chaw kho mob ntawm tus kab mob endocrine no. | Hauv Cushing syndrome, ntshav siab thiab hyperglycemia raug pom raws li cov tsos mob. |
Summary – Addison Disease vs Cushing Syndrome
Kev kuaj mob ntxov ntawm cov kab mob endocrine no tseem ceeb vim tias lawv yuav yog qhov tshwm sim ntawm qhov tshwm sim loj xws li mob qog noj ntshav. Qhov sib txawv tseem ceeb ntawm Addison tus kab mob thiab Cushing syndrome yog tus kab mob Addison yog tus cwj pwm los ntawm cov tshuaj hormones tsis txaus ntawm cortisol thiab aldosterone thaum Cushing syndrome yog tus cwj pwm los ntawm ntau tshaj cortisol. Hauv kev sau tshuaj tiv thaiv kab mob corticosteroids, tus neeg mob yuav tsum tau ua raws li txhawm rau tiv thaiv kev txhim kho ntawm qhov tsis tsim nyog thiab zam qhov teeb meem xws li Cushing syndrome.
Download PDF Version of Addison Disease vs Cushing Syndrome
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li cov ntawv sau tseg. Thov download PDF version ntawm no Qhov txawv Ntawm Addison Kab Mob thiab Cushing Syndrome.
