Qhov Tseem Ceeb Qhov txawv - Thawj Vs Tus Kheej Thib Ob
Thaum muaj kev raug mob hauv lub cev, cov ntshav hloov los ntawm cov kua dej mus rau hauv lub cev kom tsis txhob los ntshav. Qhov no tshwm sim los ntawm cov txheej txheem ntuj hu ua hemostasis. Hemostasis tuaj yeem txhais tau tias yog txheej txheem physiological uas tso tseg cov ntshav ntau dhau tom qab raug mob hauv cov hlab ntsha. Nws yog cov txheej txheem nyuaj thiab tswj tau zoo los ua kom cov ntshav txhaws tsuas yog ntawm qhov chaw raug mob. Hemostasis muaj ntau yam xws li vascular yam, platelet yam thiab coagulating proteins. Qhov kawg tshwm sim ntawm hemostasis yog coagulation ntawm cov ntshav ntawm qhov txhab. Hemostasis tshwm sim los ntawm ob theem txuas nrog lub npe hu ua thawj hemostasis thiab theem nrab hemostasis. Hemostasis pib nrog thawj hemostasis. Thaum lub sij hawm thawj hemostasis, platelets nyob rau hauv cov ntshav aggregate ntawm qhov chaw raug mob thiab tsim ib tug platelet plug los thaiv lub qhov. Thawj hemostasis yog tom qab thib ob hemostasis. Thaum lub sij hawm thib ob hemostasis, platelet plug yog ntxiv dag zog los ntawm fibrin mesh ua los ntawm proteolytic coagulation cascade. Yog li ntawd, qhov sib txawv tseem ceeb ntawm thawj thiab theem nrab hemostasis yog tias thawj hemostasis ua rau lub cev tsis muaj zog platelet ntsaws ntawm qhov chaw raug mob thaum theem nrab hemostasis ua rau nws muaj zog los ntawm kev tsim cov fibrin mesh rau nws.
Primary Hemostasis yog dab tsi?
Lub endothelium ntawm cov hlab ntsha tswj xyuas qhov chaw tiv thaiv coagulating hauv cov hlab ntsha kom tswj cov ntshav fluidity. Txawm li cas los xij, thaum muaj kev raug mob hauv cov hlab ntsha, ntau yam khoom hauv subendothelial matrix qhib thiab pib tsim cov ntshav txhaws nyob ib ncig ntawm qhov raug mob. Cov txheej txheem no hu ua hemostasis. Hemostasis muaj ob theem. Thaum thawj theem ntawm hemostasis, platelets nyob rau hauv cov ntshav aggregate thiab tsim ib tug platelet plug los thaiv qhov qhib qhov nyob rau hauv cov hlab ntsha. Cov theem no yog hu ua thawj hemostasis. Platelets tau qhib los ntawm ntau cov txheej txheem lom neeg thiab, vim li ntawd, lawv nyob ntawm qhov chaw raug mob thiab sib sau ua ke los ua ib lub ntsaws.
Primary hemostasis pib tam sim ntawd tom qab cov hlab ntsha cuam tshuam. Cov hlab ntsha nyob ze ntawm qhov chaw raug mob tau cog lus ib ntus kom nws nqaim thiab txo cov ntshav ntws. Qhov no yog thawj kauj ruam ntawm thawj hemostasis thiab nws yog hu ua vasoconstriction. Nws txo cov ntshav poob thiab txhim kho cov platelet adherence thiab ua kom lub qhov txhab ntawm qhov txhab. Thaum cov platelets tau qhib, lawv nyiam lwm cov platelets los tsim lub ntsaws los thaiv qhov qhib. Vasoconstriction tuaj yeem ua tiav los ntawm ob txoj hauv kev: los ntawm cov hlab ntsha lossis los ntawm cov molecules hu ua endothelin secreted los ntawm endothelial hlwb.
Daim duab 01: Txoj Kev Hemostasis
Platelet adhesion yog txhawb los ntawm ntau hom molecules xws li glycoproteins nyob ntawm platelets, collagens, thiab von Willebrand factor (vWf). Glycoproteins ntawm cov platelets ua raws li vWf, uas yog cov nplaum nplaum. Tom qab ntawd cov platelets sib sau ntawm qhov chaw raug mob thiab ua kom raws li kev cog lus nrog collagen. Collagen activated platelets tsim pseudopods uas faib los npog qhov chaw raug mob. Tom qab ntawd fibrinogen khi nrog receptors ntawm collagen-activated platelets. Fibrinogen muab ntau qhov chaw rau platelet los khi rau ib leeg. Yog li ntawd, lwm cov platelets kuj tau sib sau ua ke ntawm qhov raug mob thiab ua kom cov platelet mos ntsaws rau ntawm qhov raug mob.
Secondary Hemostasis yog dab tsi?
Secondary hemostasis yog theem thib ob ntawm hemostasis. Thaum lub sij hawm thib ob hemostasis, cov mos mos platelet ntsaws tsim thaum lub sij hawm thawj hemostasis yog ua kom muaj zog los ntawm kev tsim cov fibrin mesh ntawm nws. Fibrin yog ib qho insoluble plasma protein uas ua haujlwm raws li cov ntaub ntawv hauv qab polymer ntawm cov ntshav txhaws. Fibrin mesh ntxiv dag zog thiab stabilizes cov mos platelet plug tsim ntawm qhov chaw raug mob. Fibrin tsim tshwm sim los ntawm coagulation yam los ntawm coagulation cascade.
Daim duab 02: Tsim cov fibrin clot los ntawm theem nrab hemostasis
Ntau hom coagulation yam yog tsim los ntawm lub siab thiab tso rau hauv cov ntshav. Thaum pib, lawv tsis ua haujlwm thiab tom qab ntawd ua haujlwm los ntawm subendothelial collagens lossis los ntawm thromboplastin. Subendothelial collagen thiab thromboplastin raug tso tawm vim muaj kev raug mob tshwm sim hauv endothelium ntawm cov hlab ntsha. Thaum lawv tawm mus rau hauv cov ntshav, lawv ua kom cov coagulation yam hauv cov ntshav. Cov txheej txheem coagulation no tau qhib ib qho tom qab lwm qhov, thiab thaum kawg, hloov fibrinogen rau hauv fibrin. Tom qab ntawd cov fibrin txuas rau sab saum toj ntawm platelet plug thiab ua rau lub mesh los ntawm kev ua kom platelet plug muaj zog. Fibrin, ua ke nrog platelet plug, tsim cov ntshav txhaws thaum kawg ntawm cov txheej txheem hemostasis.
Dab tsi yog qhov txawv ntawm Thawj thiab theem nrab hemostasis?
Primary vs Secondary Hemostasis |
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| Primary hemostasis yog thawj theem ntawm hemostasis. | Secondary hemostasis yog theem ob ntawm hemostasis. |
| Vascular contraction, platelet adhesion thiab tsim ntawm platelet plug tshwm sim thaum thawj hemostasis. | Thaum lub sijhawm thib ob hemostasis, coagulation yam tshwm sim tau qhib thiab fibrinogen hloov mus rau hauv fibrin, tsim cov fibrin mesh. |
| Lub hom phiaj ntawm thawj hemostasis yog tsim kom muaj platelet ntsaws. | Lub hom phiaj ntawm theem nrab hemostasis yog ua kom cov platelet ntsaws ruaj khov los ntawm kev txuas cov fibrin ua ke rau saum cov platelet ntsaws thiab ua ib lub mesh. |
| Cov ntsiab lus koom nrog | |
| Primary hemostasis suav nrog platelets, glycoprotein receptors ntawm platelets, collagen, vWf, thiab fibrinogen. | Secondary hemostasis suav nrog subendothelial collagen, thromboplastin, coagulation factor, fibrinogen, thiab fibrin. |
| Duration | |
| Primary hemostasis tshwm sim nyob rau lub sijhawm luv luv. | Secondary hemostasis siv sijhawm sib piv ntev dua. |
Summary – Primary vs Secondary Hemostasis
Hemostasis yog cov txheej txheem physiological uas tiv thaiv los ntshav ntawm qhov chaw ntawm qhov raug mob thaum tswj cov ntshav ntws mus rau lwm qhov ntawm cov hlab ntsha. Cov ntshav poob yog nres los ntawm kev tsim cov hemostatic ntsaws ntawm qhov chaw raug mob. Hemostasis tshwm sim los ntawm ob theem hu ua thawj thiab theem nrab hemostasis. Thawj hemostasis pib tam sim ntawd tom qab raug mob thiab tsim cov platelet ntsaws rau ntawm qhov chaw raug mob. Cov platelet ntsaws no txhawb ntxiv los ntawm kev hloov pauv ntawm fibrinogen rau hauv fibrin los ntawm coagulation cascade thaum lub sij hawm thib ob hemostasis. Qhov no yog qhov txawv ntawm thawj thiab theem nrab hemostasis.
Download PDF Version of Primary vs Secondary Hemostasis
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li cov ntawv sau tseg. Thov rub tawm PDF version ntawm no Qhov txawv nruab nrab ntawm theem pib thiab theem nrab Hemostasis.
Image Courtesy:
1. "1909 Ntshav Clotting" Los ntawm OpenStax College - Anatomy & Physiology, Connexions Web site. Lub Rau Hli 19, 2013., (CC BY 3.0) via Commons Wikimedia
2. "Coagulation puv" Los ntawm Joe D - Tus kheej ua haujlwm (CC BY-SA 3.0) ntawm Commons Wikimedia
