Qhov Tseem Ceeb Qhov txawv – Cell Migration vs Invasion
Kev tsiv teb tsaws chaw thiab kev ntxeem tau yog ob txoj hauv kev uas tuaj yeem pom hauv cov hlwb. Cell migration yog txheej txheem tseem ceeb hauv ntau cov kab mob hauv lub cev rau kev txhim kho thiab kev saib xyuas. Nws yog ib qho txheej txheem hauv nruab nrab uas tshwm sim hauv cov hlwb rau kev loj hlob ntawm cov ntaub so ntswg, kho qhov txhab, lub cev tiv thaiv kab mob, thiab lwm yam. Cell invasion, uas muaj feem xyuam rau cell migration, hais txog lub peev xwm ntawm cov hlwb los ua motile thiab taug kev los ntawm extracellular matrix nyob rau hauv cov ntaub so ntswg los yog infiltrate. rau hauv cov ntaub so ntswg nyob sib ze. Qhov sib txawv tseem ceeb ntawm kev tsiv teb tsaws ntawm tes thiab kev cuam tshuam ntawm tes yog tias, kev tsiv teb tsaws ntawm tes yog hais txog kev txav mus los ntawm tes thaum lub cell invasion hais txog cov cell nquag mus rau hauv cov ntaub so ntswg lossis cov hlwb nyob sib ze.
Cell Migration yog dab tsi?
Cells txav ntawm ib qhov chaw mus rau lwm qhov chaw rau ntau lub hom phiaj. Cell migration yog txheej txheem cellular tseem ceeb rau cov kab mob multicellular. Thaum lub sij hawm gastrulation, cov nplooj ntawv epithelial migrate los qhia morphogenesis. Thaum lub sij hawm kev loj hlob ntawm lub paj hlwb, cell migration yog ib qho tseem ceeb heev. Cov ntaub so ntswg regeneration kuj yuav tsum tau tsiv teb tsaws ntawm tes. Lub cev tiv thaiv kab mob siv cell motility xa cov qe ntshav dawb mus rau qhov chaw kis kab mob los tiv thaiv lub cev tiv thaiv kab mob. Leukocytes yog qhov muaj zog heev thiab qhia kev tsiv teb tsaws sai rau cov khoom txawv teb chaws kom tsis txhob muaj cov kab mob. Kev kho qhov txhab yog qhov tshwm sim ntawm kev tsiv teb tsaws ntawm tes.
Cell migration yuav tsum tau hloov pauv ntawm cov duab ntawm tes thiab tawv kom cuam tshuam nrog cov ntaub so ntswg ib puag ncig. Extracellular matrix muab lub substrate rau cell migration. Cells tau ntim nrog cov nplaum nplaum proteins thiab thaum pib ntawm kev tsiv teb tsaws, theem ntawm cov proteins no txo kom tso cai rau cov cell tsiv teb tsaws. Cell migration yog pom nyob rau hauv cov ntaub so ntswg siv ib tug cell migration assay. Nws ntsuas tus naj npawb ntawm cov hlwb taug kev los ntawm cov porous membrane.
Cell Invasion yog dab tsi?
Cell invasion yog ib hom kev tsiv teb tsaws ntawm tes uas cuam tshuam nrog ntau yam pathologies. Nws tuaj yeem txhais tau tias yog lub peev xwm ntawm cov hlwb kom txav mus los ntawm extracellular matrices thiab nkag mus rau hauv cov ntaub so ntswg los yog nkag mus rau hauv cov ntaub so ntswg tshiab nyob ze. Nws koom nrog cov enzymes proteolysis xws li lysosomal hydrolysates, collagenases, plasminogen activators, thiab lwm yam. Cell ntxeem tau muaj nyob rau hauv cov qog nqaij hlav malignant. Cov qog nqaij hlav qog nqaij hlav nthuav tawm mus rau qhov chaw thib ob nrog kev pab ntawm kev cuam tshuam ntawm tes. Cell ntxeem tau kuj txhais tau tias yog lub peev xwm ntawm malignant qog cell mus txeeb cov ntaub so ntswg ib puag ncig. Kev cuam tshuam ntawm tes tso cai rau cov qog nqaij hlav qog noj ntshav hloov pauv txoj haujlwm hauv cov ntaub so ntswg thiab kis mus rau thaj tsam loj ntawm lub cev. Cell ntxeem tau muaj cov haujlwm sib txawv. Lawv yog adhesion, motility, detachment, thiab extracellular matrix proteolysis.
Daim duab 02: Cell ntxeem tau
Qhov txawv ntawm Cell Migration thiab Invasion yog dab tsi?
Cell Migration vs Invasion |
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| Cell migration yog cov txheej txheem ntawm lub cev txav mus los hauv cov lus teb rau cov cim tshuaj lom neeg. | Cell invasion yog lub peev xwm ntawm cov hlwb kom tsiv teb tsaws thiab taug kev los ntawm extracellular matrix nyob rau hauv cov ntaub so ntswg thiab nkag mus rau hauv cov ntaub so ntswg nyob sib ze. |
| Cell migration yog ib qho tseem ceeb rau kev tiv thaiv kab mob kom raug, kho qhov txhab thiab cov ntaub so ntswg homeostasis. | Ib yam txawv txav ntawm tes ua rau mob qog noj ntshav. |
Summary – Cell Migration vs Invasion
Kev kawm txog kev cuam tshuam ntawm tes thiab kev tsiv teb tsaws yog qhov tseem ceeb rau kev nkag siab zoo dua ntawm cov txheej txheem lom neeg thiab molecular uas tshwm sim hauv cov kab mob. Cell migration yog ib txwm txav ntawm cov hlwb los ntawm ib qho chaw mus rau lwm qhov hauv kev teb rau cov teeb meem tshuaj. Kev tsiv teb tsaws yog ib qho txheej txheem tseem ceeb uas pab ntau yam kev siv lub cev thiab cov txheej txheem pathological, suav nrog kev loj hlob ntawm embryonic, kev sib txawv ntawm tes, kev tsim cov ntaub so ntswg, kho qhov txhab, teb rau lub cev tiv thaiv kab mob, mob qog noj ntshav thiab lwm yam kev cuam tshuam ntawm tes yog cov txheej txheem uas cov hlwb nkag mus rau hauv cov ntaub so ntswg thiab rhuav tshem cov ntaub so ntswg., tshwj xeeb tshaj yog rau cov qog nqaij hlav cancer. Qhov no yog qhov sib txawv tseem ceeb ntawm kev tsiv teb tsaws ntawm tes thiab kev ntxeem tau.
