Gigantism vs Acromegaly
Gigantism thiab acromegaly yog ob yam kab mob uas muaj tib yam kab mob thiab kev nthuav qhia me ntsis. Txawm hais tias lawv muaj tib yam kab mob mechanism, ob qho tib si muaj qhov sib txawv kiag li tsuas yog vim muaj hnub nyoog pib. Gigantism yog tshwm sim yog tias tus kab mob mechanism pib thaum yau. Acromegaly yog tshwm sim yog tias tus kab mob mechanism pib tom qab puberty. Kab lus no yuav tham txog cov txheej txheem kab mob thiab cov yam ntxwv kho mob, cov tsos mob, ua rau, kev tshawb nrhiav thiab kev kuaj mob, thiab kev kwv yees ntawm acromegaly thiab gigantism, thiab kuj muaj qhov sib txawv ntawm ob qho kev mob.
Ua ntej puberty yuav luag tag nrho cov pob txha hauv lub cev loj hlob hauv qhov ntev, dav, qhov hnyav, thiab lub zog. Tom qab kev laus, tom qab kev loj hlob spurt, kev loj hlob qeeb thiab nres nyob ib ncig ntawm 24-26 xyoo. Cov cheeb tsam loj hlob ntawm cov pob txha ntev hu ua epiphysis. Thaum puberty, vim yog cov nyhuv ntawm cov tshuaj hormones kev sib deev, epiphyses fuse. Tsuas yog ob peb pob txha hauv lub cev loj hlob tom qab ntawd. Cov lus piav qhia ntawm molecular rau qhov tshwm sim hais tias qhov kev loj hlob yog vim qhov tso tawm ntau dhau los yog cuam tshuam ntawm insulin zoo li kev loj hlob. Tib neeg txoj kev loj hlob yog nyob rau hauv kev tswj ntawm cov tshuaj hormones pituitary. Lub hypothalamus secretes ib yam tshuaj hu ua Growth Hormone Releasing Hormone. Nws ua rau lub anterior pituitary thiab ua rau tso tawm ntawm Growth Hormone. Kev loj hlob hormone ua rau cov pob txha epiphysis ua rau cov pob txha loj hlob. Insulin zoo li kev loj hlob zoo yog ib qho molecule tsim nyob rau hauv lub cev uas ua rau cov pob txha epiphyses ua rau lub cell faib sai thiab pob txha loj hlob. Raws li cov kev sib raug zoo molecular no, peb lub ntsiab mechanisms tau raug txheeb xyuas. Hypothalamus secreting ntau ntau ntawm Growth Hormone Releasing Hormone, anterior pituitary secreting ntau npaum li cas ntawm Growth Hormone, thiab ntau ntau ntawm cov tshuaj insulin zoo li kev loj hlob zoo losis tswvyim dabtsi protein uas prolongs IGF kev txiav txim yog peb txoj kev kho kab mob. Feem ntau, kev loj hlob ntau dhau yog vim pituitary hyper-secretion ntawm Growth Hormone. Txawm li cas los xij, hauv qee kis xws li McCune Albright Syndrome, Neurofibromatosis, Tuberous sclerosis, thiab Ntau Yam Endocrine Neoplasia Hom 1 tuaj yeem ua rau muaj kev loj hlob ntau dhau, thiab.
Ob leeg gigantism thiab acromegaly muaj qee qhov kev nthuav qhia zoo sib xws. Ob qho xwm txheej yuav ua rau mob taub hau vim yog cov tshuaj hormones pituitary secreting qog. Kev pom kev cuam tshuam yog tshwm sim vim qog pituitary nias ntawm optic chiasm. Ob qho xwm txheej yuav ua rau tawm hws ntau dhau, mob me mus rau nruab nrab rog thiab osteoarthritis. Ob qho xwm txheej xav tau Kev Loj Hlob Hormone Levels, CT hlwb, Serum Prolactin qib, ceev ntshav kuaj ntshav. Somatostatin hauv cov tshuaj tiv thaiv kev loj hlob thiab zoo heev tiv thaiv kev loj hlob hormone ntau dhau. Dopamine agonists thiab phais yog lwm yam kev xaiv.
Gigantism yog qhov tshwm sim yog tias tus kabmob pib pib thaum yau. Gigantism tsis tshua muaj heev; Txog tam sim no, tsuas yog 100 kis tau tshaj tawm. Gigantism tuaj yeem pib ntawm txhua lub hnub nyoog ua ntej epiphyseal fusion thaum puberty. Nws muaj mob taub hau, pom kev cuam tshuam, rog rog, mob pob qij txha thiab tawm hws ntau dhau. Cov neeg tuag coob ntawm kev loj hlob thaum yau tsis paub vim muaj tsawg tus neeg mob.
Acromegaly yog qhov tshwm sim yog tias tus kab mob mechanism pib tom qab yug me nyuam. Acromegaly yog ntau dua li gigantism. Acromegaly pib nyob ib ncig ntawm 3rd xyoo caum. Acromegaly kuj muaj cov tsos mob zoo li gigantism, tab sis lawv tsuas tshwm sim tom qab lub neej. Acromegaly muaj qhov kev tuag ntawm ob mus rau peb npaug ntawm cov pejxeem.
Qhov txawv ntawm Acromegaly thiab Gigantism yog dab tsi?
• Acromegaly yog qhov ntau dua li gigantism. Gigantism yog qhov tsawg kawg nkaus. Txog tam sim no, tsuas yog 100 kis tau tshaj tawm.
• Kev tuag ntawm gigantism thaum yau tsis paub vim muaj tsawg tus neeg mob. Acromegaly muaj qhov kev tuag ntawm ob mus rau peb npaug ntawm cov pejxeem.
• Gigantism tuaj yeem pib ntawm txhua lub hnub nyoog ua ntej epiphyseal fusion thaum puberty. Acromegaly pib nyob ib ncig ntawm 3 xyoo caum.
• Gigantism feature siab dhau heev thaum acromegaly nthuav dav ntau dhau ntawm lub puab tsaig, tus nplaig thiab ntiv tes xaus.
